Retinal Pigmented Epithelium
Original Article Oxidized low density lipoprotein (oxLDL) promotes mitochondrial dysfunction and induces apoptosis in retinal pigmented epithelium cells
... of retinal pigment epithelium (RPE) cells, as may play a vital role in the pathogenesis of age-related macular degeneration ...in retinal pigmented epithelium ARPE-19 cells, and ...
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In vitro differentiation of cGMP-grade retinal pigmented epithelium from human embryonic stem cells
... to retinal degeneration is expected to reach 6 million annually in ...The retinal degenerative diseases affect the macula, which is responsible for central and detailed ...of retinal pigmented ...
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The retinal pigmented epithelium – from basic developmental biology research to translational approaches
... the retinal pigmented epithelium (RPE) is at the forefront of developmental biology and stem cell ...of retinal dystrophies; they also constitute an important model to study developmental ...
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Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development
... The synchronized differentiation of neuronal and vascular tissues is crucial for normal organ development and function, although there is limited information about the mechanisms regulating the coordinated development of ...
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MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors
... the retinal pigmented epithelium (RPE) results in degeneration of photoreceptors and vision loss and is correlated with common blinding disorders in ...
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Reprogramming of the chick retinal pigmented epithelium after retinal injury
... Additional file 1: Figure S1. Pluripotency inducing factors are present in the developing chick eye at E7 and after injury. (A-E) Immunohistochemical staining using antibodies against pluripotency inducing factors c-Myc ...
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Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium
... After vitreous shaving, the posterior pole and supe- rior retina was detached using a 41-gauge needle injec- tion (Bausch and Lomb, USA) of approximately 1 ml of balanced saline solution (BSS) starting near the optic ...
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Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes
... The OV cells can differentiate into either pigmented or neural cells, even in the absence of the surface ectoderm (Hyer et al., 1998). Surface ectoderm organizes the placement of these cell types by instructing ...
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Zebrafish interphotoreceptor retinoid binding protein: differential circadian expression among cone subtypes
... In retinas fixed at mid-dark, only one photoreceptor cell type appeared to hybridize with the IRBP riboprobe (Fig. 8C). This photoreceptor was identified as the short single ultraviolet cone on the basis of three lines ...
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Retinal response in the post metamorphic American eel (Anguilla rostrata) (Pisces, Teleostei)
... Use of tidal streams by migrating elvers (Anguilla vulgaris). Ultrastructure of the retinal pigmented epithelium of light and dark adapted young pigmented and mature silver [r] ...
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Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning
... the retinal pigmented epithelium generate RA that delivers an essential signal to the neural retina required for morphogenetic movements that lead to ventral invagination of the optic ...
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Choroidal thickness in older patients with central serous chorioretinopathy
... The measurement of the choroid was not possible in 5 eyes (29.4 %) with active CSCR and in two inactive con- tralateral eyes (15.4 %). This is likely due to a loss of signal penetration and intensity due to the increased ...
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Transcriptional Reactivation of OTX2, RX1 and SIX3 during Reprogramming Contributes to the Generation of RPE Cells from Human iPSCs
... into retinal pigmented epithelium (RPE) holds great promise in cell replacement therapy for patients suffering from de- generative eye diseases, including age-related macular degeneration ...and ...
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Knobloch syndrome associated with Polymicrogyria and early onset of retinal detachment: two case reports
... This 13-year-old female was the sibling of the 7-month- old boy from Case 1. She had a past ocular history significant for an ERG demonstrating mild cone-rod dystrophy, bilateral macular chorioretinal staphylomas, ...
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<p>Tamoxifen Induced Pachychoroid Pigment Epitheliopathy with Reversible Changes After Drug Discontinuation</p>
... cant retinal toxicity induced by 7 years ’ Tamoxifen consumption in which patient ’ s visual acuity and paraclinical fi ndings remarkably improved after drug ...was retinal pigment epithelium (RPE) ...
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Enhanced generation of retinal progenitor cells from human retinal pigment epithelial cells induced by amniotic fluid
... Here, we have shown that AF was able to promote ret- inal progenitor gene expression levels in 30% AF control cultures, while immunocytochemical analysis of 30% AF control cultures indicated a decrease in the number of ...
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Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease
... by indirect co-culture. In vivo, hiPSC-RPE cells were able to survive in rd10 mice up to 2 weeks post-surgery. hiPSC-RPE cells rescued and improved the reduced ONL, photoreceptor loss, impaired light-avoidance be- ...
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Modified protocol for in vivo imaging of wild-type mouse retina with customized miniature spectral domain optical coherence tomography (SD-OCT) device
... This protocol outlines and evaluates a modified scanning procedure for a customized spectral domain optical coherence tomography (SD-OCT) imaging apparatus within the wild-type C57Bl/6 mouse posterior segment. This ...
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Long-term success of intravitreal bevacizumab for choroidal neovascularization associated with choroidal osteoma
... the retinal pigment epithelium (RPE) and serous retinal detachment (SRD) at the posterior pole of the left eye (Figure ...pigment epithelium detachment and several points of leakage superior ...
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The advancement of human pluripotent stem cell derived therapies into the clinic
... hPSC-derived cell therapeutics advancing to clinical testing include retinal pigment epithelium RPE for retinal degenerative diseases, dopaminergic neurons Neurons for Parkinson’s diseas[r] ...
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