retinoic acid-binding protein
The retinoic acid binding protein CRABP2 is increased in murine models of degenerative joint disease
... In an earlier study of a rat surgically induced model of DJD, Appleton and colleagues reported that Crabp2 expression as determined from microarray analysis was elevated in the OA joint four weeks post-surgery [30]. ...
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Retinoic acid inhibits induction of c Jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen activated protein kinase pathways in human skin in vivo
... c-Jun protein (for at least 24 h) induced by UV radiation in human skin, since UV radiation stimulated c-Jun phosphoryla- ...c-Jun protein induction required prolonged pretreatment ( ...cellular ...
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Expression of retinoic acid-binding proteins and retinoic acid receptors in sebaceous cell carcinoma of the eyelids
... clear. Retinoic acid (RA) signaling is essential for skin epidermal differentiation including the ...cellular retinoic acid binding protein 1 (CRABP1), cellular retinoic ...
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Characterisation of chicken RXR-γ
... OF RETINOIC ACID ON HINDBRAIN DEVELOPMENT As stated in section ...of retinoic acid can have dramatic effects on the development of the central and peripheral nervous systems (CNS, ...cellular ...
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Effects of vitamin A deficiency and repletion on rat insulin secretion in vivo and in vitro from isolated islets
... retinol binding protein (CRBP) and cellular retinoic acid binding protein ...with retinoic acid (RA) repletion, 2 micrograms/g diet compared to release from islets ...
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The molecular biology of acute promyelocytic leukaemia and its response to therapy
... retinoblastoma protein (pRB) localises to the nuclear bodies through an interaction with PML (Alcalay et al, ...for retinoic acid dependent transactivation of the cyclin-dependent kinase inhibitor ...
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Genetics and functions of the retinoic acid pathway, with special emphasis on the eye
... Early studies revealed that retinoids could not be synthe- sized de novo in most animals [reviewed in [13]]. Hence, the major source of retinoids during embryonic and fetal development is through placental transfer of ...
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First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: A new dimension to the STRA6 phenotype
... retinol-binding protein (RBP) and is responsible for mediating vitamin A uptake from circulation to target ...The protein is expressed in a number of organs that require vitamin A for normal ...
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Localization of RIHB (retinoic acid induced heparin binding factor) transcript and protein during early chicken embryogenesis and in the developing wing
... [nl I D BinI 17 169 1S0 (19931 369 Original Artic/I' Localization of RIHB (retinoic acid induced heparin binding factor) transcript and protein during early chicken embryogenesis and in the developing[.] ...
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PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity
... hybrid protein PML/RARA, that acts as a transcriptional repressor impairing the expression of genes that are critical to myeloid ...oncosuppressor protein PTEN, as compared to blast cells from other AML ...
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A phosphorylation defective retinoic acid receptor mutant mimics the effects of retinoic acid on EGFR mediated AP-1 expression and cancer cell proliferation
... receptor protein was truncated after amino acid 403, thereby deleting the AF-2 domain ...for binding sites, cofactor interaction, ligand binding) has not been ...
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Biological roles of CCAAT/Enhancer-binding protein delta during inflammation
... and retinoic acid receptor, on the promoter regions of proinflammatory mediators activates CEBPD in an interleukin-1 receptor-associated kinase 1-dependent manner ...flammatory protein 2 and 1α in ...
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Polyomavirus Small t Antigen Prevents Retinoic Acid-Induced Retinoblastoma Protein Hypophosphorylation and Redirects Retinoic Acid-Induced G0 Arrest and Differentiation to Apoptosis
... tively regulated by signals from two cell surface receptors, c-FMS (47, 50, 52) and BLR1 (3, 4). c-FMS is a PDGF class transmembrane tyrosine kinase receptor, while BLR1, also known as CXCR1, is a putative seven-pass ...
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Cellular retinoic acid binding proteins are essential for hindbrain patterning and signal robustness in zebrafish
... in protein sequence to human CRABP2 (Sharma et ...fatty acid-binding proteins or differential regulation in placental mammals at the level of maternal and extra- embryonic tissues (Sapin et ...
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The role of stromal cancer-associated fibroblasts in pancreatic cancer
... trans retinoic acid; CAF: Cancer-associated fibroblast; CA-MSCs: Cancer-associated mesenchymal stem cells; CHOP: CCAAT- enhancer-binding protein homologous protein; ECM: Extracellular ...
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Identification of influential proteins in the classical retinoic acid signaling pathway
... RA binding proteins, little is known about their expression levels across different human cell ...a protein can also vary considerably from cell to cell within a population of cells of the same ...RA ...
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The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice
... fatty acid oxidation and insulin sensitivity in muscle and liver, and the antidiabetic effects of a low dose of pioglit- azone were lost in mice in which adiponectin deficiency was introduced into the ob/ob ...
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The Therapeutic potential of lentivector delivered RNAi
... proliferation assays were carried out before transduction, and at 24 hours intervals thereafter. Two additional assays were subsequently carried out at the time of maximal shRNA expression (48 and 72 hours). The results ...
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Molecular evolution and expression profile of the chemerine encoding gene RARRES2 in baboon and chimpanzee
... the retinoic acid receptor responder 2 (RARRES2) gene is an adipocytesecreted protein with autocrine/paracrine functions in adipose tissue, metabolism and inflammation with a recently described ...
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Human skin levels of retinoic acid and cytochrome P 450 derived 4 hydroxyretinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro
... individual retinoic acid receptors (RARs) or retinoid X receptor-alpha (RXR-alpha) and a chloramphenicol acetyl transferase (CAT) reporter plasmid containing a retinoic acid responsive element ...
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