Reverse mutation
ALLELIC RELATIONSHIPS AND REVERSE MUTATION IN ESCHERICHIA COLI
... A series of lactose-negative (Lac-) mutants in strain K-12 which revert at different rates has provided experimental material for the study of reverse mutation, t[r] ...
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Genetic instability at the agouti locus of the mouse (Mus musculus). I. Increased reverse mutation frequency to the Aw allele in A/a heterozygotes.
... Stability and structure of mutant alleles at the agouti locus: Our results indicate a greatly increased reverse mutation frequency to the A" allele in the offspring of[r] ...
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FORWARD AND REVERSE MUTATION IN A HISTIDINE-REQUIRING STRAIN OF ESCHERICHIA COLI
... A part of each treated culture was plated on minimal agar to determine the number of h+ mutants present at zero time, and another part was diluted with medium cont[r] ...
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REVERSE MUTATION STUDIES ON THE FORKED LOCUS IN DROSOPHILA MELANOGASTER
... Following irradiation of mature sperm, none of the four f alleles tested on an extensive scale gave rise to induced ff reversals, whereas one particular allele, f””, pro[r] ...
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EVALUATION OF THE POTENTIAL GENOTOXICITY AND DEVELOPMENTAL TOXICITY OF MANJARIX
... Bacterial reverse mutation assay and in vivo chromosome aberrations and micronucleus test in ...Bacterial reverse mutations assay was performed in Salmonella typhimurium strains and Escherichia coli ...
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Forward and reverse mutations in stages of cancer development
... forward-reverse mutation cycles (FR-cycles) be- tween different cancer developmental stages, the greater LOH rates than GOH rates in the N-to-T transition, the strong lineage effects observed in the ...
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Genotoxicity evaluation of Oryeong san water extract using in vitro and in vivo tests
... The present study demonstrated that ORSE, a traditional herbal medicine for the treatment of various renal dis- eases, was not genotoxic using an in vitro chromosomal abbreviation test, an in vitro bacterial ...
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MUTATIONS RESULTING FROM THE TRANSFORMATION OF BACILLUS SUBTILIS
... Therefore, the frequency of reverse mutation in every transformation event could be calculated as 2.4 X for adenine; for methionine it was 1.7 x The observed reversion du[r] ...
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Evolution of genotoxicity test methods in Japan
... assay using Salmonella typhimurium, the so-called “Ames test.” His research group examined approximately 300 substances using Ames test and found a high correlation between carcinogenicity and genotoxicity, indicating ...
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STUDIES WITH PURPLE ADENINE MUTANTS IN NEUROSPORA CRASSA. III. REVERSION OF X-RAY-INDUCED MUTANTS
... adenine independence, and to find out whether reversion was caused by suppres- SQI or reverse mutation. Although adenine inde- pendence is dominant to adenine dependence in these het[r] ...
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Assessment of drug induced genotoxicity in mammalian cells and the contribution of topoisomerase II inhibition
... bacterial reverse mutation (Ames) test but unexpectedly positive in the mouse lymphoma assay (MLA) at all concentrations analysed (55 to 111 µmol/L) in the absence and presence of exogenous metabolism ...
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Evaluation of Mutagenicity of Refinery Waste Effluents
... reverse mutation assay in Salmonella typhimurium TA97a, TA98, TA100, TA102, and TA104 strains with and without metabolic activation... MATERIALS AND METHODS.[r] ...
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THE GENETICS OF ALKALINE PHOSPHATASE FORMATION IN BACILLUS SUBTILIS
... Reverse mutation at the region P-ZZ and region R-Z: The mutants belonging to region P-I1 gave constitutive strains spontaneously, and the mutants belonging to region R-I [r] ...
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Decreased Processivity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Containing Didanosine-Selected Mutation Leu74Val: a Comparative Analysis of RT Variants Leu74Val and Lamivudine-Selected Met184Val
... of mutation Leu74Val in clinical isolates during clin- ical trials with didanosine monotherapy in AZT-experienced population has been reported to occur frequently in some studies (16, ...Leu74Val mutation ...
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Reversion of a Moloney murine leukemia virus RNase H mutant at a second site restores enzyme function and infectivity.
... polymeric RNA in RNA-DNA hybrid or RNA-RNA duplex form (3). After electrophoresis of the proteins, the gel was incubated in several changes of buffer to permit renaturation of the proteins and digestion of the substrate. ...
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Pseudodiploid Genome Organization Aids Full-Length Human Immunodeficiency Virus Type 1 DNA Synthesis
... that reverse transcription of a single-copy gene will be more error prone than replication in the presence of a second ...vector reverse transcription was slightly more error prone than that of ...
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Replication of Phenotypically Mixed Human Immunodeficiency Virus Type 1 Virions Containing Catalytically Active and Catalytically Inactive Reverse Transcriptase
... of reverse transcription is shown in ...of reverse transcription cannot be monitored directly because PCR-based methods do not readily distinguish com- plementary DNA ...in reverse transcription are ...
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High density lipoprotein deficiency with xanthomas A defect in reverse cholesterol transport caused by a point mutation in the apolipoprotein A I gene
... triglycerides are normal. The genetic defect could be identified as a base insertion into the third exon of the apoA-I gene. This leads to a nonsense peptide sequence beginning at amino acid 5 of the mature plasma ...
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An Avian Influenza H5N1 Virus That Binds to a Human-Type Receptor
... the mutation may stabilize SA ␣ 2,6Gal in its optimal cis conformation in the binding ...The mutation was found in approximately half of the viral sequences directly amplified from a respiratory specimen of ...
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Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... (Leu74Val) mutation in human immunodeficiency virus type 1 reverse transcriptase (RT) develops as a consequence of didanosine (ddI) therapy and is associated with a decreased susceptibility to ...Leu74Val ...
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