Rho-associated
Endothelial repair in stented arteries is accelerated by inhibition of Rho associated protein kinase
... polarity associated with altered actin dynamics. Inhibition of Rho-associated protein kinase (ROCK) enhanced endothelialization of ridged surfaces by promoting migratory polarity under bidirectional ...
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Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
... RBD: Rho-binding domain; RhoA: ras homolog gene family member A; RhoGEF: Rho guanine nucleotide exchange factor; ROCK: Rho-associated coiled-coil kinase; SFK: Src family kinase; Shh: sonic ...
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Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis
... enzyme, Rho-associated protein kinase 2 (ROCK2), was identified as ...are associated with paraneoplastic encephalitis and should be screened for when paraneoplastic neurological syndromes, especially ...
10
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells
... all Rho proteins, we next monitored the in vivo effects of inhibiting either RhoA or RhoB ...individual Rho proteins ...mutant Rho constructs were devoid of stress fibers when compared to their ...
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Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
... Matrix metalloproteinases (MMPs) and zinc-depen- dent endopeptidases are a family of structurally related zymogens that are capable of degrading the ECM, including the basement membrane. They are presumed to be ...
11
Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase.
... are associated with increased risk of complications such as throm- bogenicity, 29 the influence of stent strut geometry on local hemodynam- ics and EC repair remains an important consideration in stent ...
13
Inhibition of Rho-associated kinases disturbs the collective cell migration of stratified TE-10 cells
... In cells transfected with ROCK siRNAs, the migration distance of the stratified region toward the rear of the wounded edge also signifi- cantly decreased by 20–30 % relative to negativ[r] ...
15
Ocular hypotensive effects of a Rho-associated protein kinase inhibitor in rabbits
... In our study, although the combination of ripasudil with other drugs with ocular hypotensive effects resulted in significant reductions in IOP compared with controls, the coadmini[r] ...
7
Vangl2 cooperates with Rab11 and Myosin V to regulate apical constriction during vertebrate gastrulation
... through Rho-associated kinase (Marlow et ...been associated with the regulation of adherens junctions (Lindqvist et ...previously associated with PCP signaling due to the apical distribution ...
9
Novel ocular antihypertensive compounds in clinical trials
... inhibitor, Rho-associated protein kinase inhibitors, adenosine receptor agonists, an angiotensin II type 1 receptor antagonist, cannabinoid receptor agonists, and a serotonin receptor ...
11
Development and characterization of a polarized human endometrial cell epithelia in an air–liquid interface state
... The isolation of human endometrial epithelial cells was conducted as described in a previous study with min- imal modification [7]. Briefly, the human endometrial biopsy was minced with scissors into small pieces of less ...
7
Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer
... A/ Rho-associated protein kinase (RhoA/ROCK) inhibitors (C3 and Y-27632) inhibited the invasiveness of ovarian cancer cells and leptin-induced upA expression [50] This il- lustrates not only the involvement ...
9
METABOLISM OF RIBOSOMAL RNA IN MUTANTS OF ESCHERICHIA COLI DOUBLY DEFECTIVE IN RIBONUCLEASE III AND THE TRANSCRIPTION TERMINATION FACTOR RHO
... (The pat- terns of rRNA synthesis observed in rnc+ rho+ strains are identical with those observed in rnc+ rho strains, and therefore in Figures 5 and 6 the patterns of rRN[r] ...
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Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction
... of Rho-kinase to airway responsiveness after the EAR and ...of Rho- kinase in contractile airway ...of Rho-kinase in guinea pig air- way smooth muscle contraction ex vivo and airway responsiveness in ...
7
Rho GTPase activating protein 18: a biomarker associated with good prognosis in invasive breast cancer
... Increased cytoplasmic expression of ARHGAP18 was significantly associated with improved outcome in terms of longer BCSS (p=0.004) and DMFI (p=0.012), Figure 2. Using multivariate cox regression analysis, this ...
29
An emerging treatment option for glaucoma: Rho kinase inhibitors
... to Rho kinase. There exists a general consensus that Rho kinase inhibitors alter actomyosin activity in the TM while exerting minimal toxic effects on the eye and, therefore, may be of thera- peutic value ...
8
A Rho-Type GTPase, rho-4, Is Required for Septation in Neurospora crassa
... of Rho-type ...activate Rho-type GTPases (43); GAPs, which lead to deacti- vation of Rho-type GTPases by increasing the intrinsic GTPases activity (3); and GDIs, which regulate Rho-type ...
13
The evolutionary history of effectors downstream of Cdc42 and Rac
... (a Rho function) as well as cytokinesis and Rho-medi- ated transcriptional activation of the serum response factor ...for Rho- family GTPases that, like Paks, mediate both cytoskeletal and ...
8
Altstätter, Johannes (2011): Functional analysis of α-Parvin in vivo. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... reorganization of actin filaments. On the one hand, these proteins can sever and/or depolymerize actin fibers and thus facilitate actin fiber disassembly. On the other hand, they can also promote the assembly of new ...
149
Rho A prenylation and signaling link epithelial homeostasis to intestinal inflammation
... as Rho-A signaling, epithelial adherens junctions, and regulation of actin-based motility by Rho (Figure ...involving Rho GTPases other than Rho-A, such as Cdc42 signaling, showed no ...
17