Rho-associated kinase 1
Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis
... Over the next 6 months he developed a progressive cognitive decline followed by an acute deterioration with agitation, somnolence and gait disturbance. In January 2015 he was readmitted with hyperkinetic de- lirium and ...
10
Fasudil, an inhibitor of Rho-associated coiled-coil kinase, improves cognitive impairments induced by smoke exposure
... The C57BL/6 mice were exposed to cigarette smoke 1 hour once a day for four months using 3R4F Kentucky reference cigarettes (University of Kentucky, Lexington, KY, USA) by a standardized smoking procedure. Animals ...
9
Rho-Associated Coiled-Coil Kinase (ROCK) in Molecular Regulation of Angiogenesis
... migration via the RhoA/Rho kinase/moesin pathway [61]. In another study, estradiol enhances the transcription, protein expression, and activity of RhoA in an estrogen receptor-dependent manner [62]. ...
17
Ocular hypotensive effects of a Rho-associated protein kinase inhibitor in rabbits
... Each drug was administered to the eight eyes of eight rab- bits, and IOPs were measured on the same day. One week later, the next session began using the next drug regime on the same animals. All drugs were initially ...
7
Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle
... phosphoglycerate kinase 1 (PGK1), is a target gene of both the myc oncogene pathway and the hypoxia inducible factor 1α (HIF-1α) and is therefore considered as a marker gene for a number of malignant ...
9
Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor
... the Rho-associated kinase, ROCK (16). As shown in Figure 1, in the absence of Y-27632, the growth rate of all 3 keratinocyte types slowed with time, and senescence was observed at ...
9
Novel ocular antihypertensive compounds in clinical trials
... inhibitor, Rho-associated protein kinase inhibitors, adenosine receptor agonists, an angiotensin II type 1 receptor antagonist, cannabinoid receptor agonists, and a serotonin receptor ...
11
Original Article Bone marrow-derived mesenchymal stem cells alleviates renal injury in severe acute pancreatitis via RhoA/Rho kinase
... enzyme. Rho kinase (ROCK) is the most important downstream effector of Rho [10], it includes ROCK I and ROCK ...also associated with the RhoA/ROCK signaling pathway ...
6
Development and characterization of a polarized human endometrial cell epithelia in an air–liquid interface state
... a Rho-associated protein kinase (ROCK) inhibitor – modified medium and subsequently characterize endometrial epithelium generated with primary cells cultured in an air – liquid interface (ALI) ...
7
Direct Rho-associated kinase inhibiton induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells
... myelin associated glycoprotein (MAG) [1], chondroitin sulfate proteoglycans (CSPGs) and oligodendrocyte myelin glycoprotein (OMgp) [2, ...small Rho-GTPases and Rho kinase can promote ...
18
Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase.
... Figure 1 Fluid flow in the ridged chamber slide. (A) Configuration of the ridged flow chamber. (B–D) CFD were carried out to simulate flow patterns and WSS magnitude assuming an inlet flow rate of 21.6 ml/min. ...
13
Endothelial repair in stented arteries is accelerated by inhibition of Rho associated protein kinase
... Fig. 1. Fluid flow in the ridged chamber slide. (A) Configuration of the ridged flow chamber. (B-D) CFD were carried out to simulate flow patterns and WSS magnitude assuming an inlet flow rate of 21.6 ml/min. Flow ...
28
Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathway
... NaF, 1% NP-40, 1 μg/ml leupeptin, 1 μg/ml antipain, and 1 mM phenylmethyl sulfonyl fluor- ide [PMSF]), and the protein concentrations of the resulting cell lysates were determined using a BCA ...
11
A quantum chemical analysis of the inhibition of protein kinase A (PKA) and Rho associated protein kinase 2 (ROCK2) by a series of urea based molecules
... In this figure A denotes the original case: local µ is located at -0.5 eV. In case B we have shifted downwards the LUMO energy and µ has now a value of -1 eV. In case C the HOMO energy was shifted downwards and µ ...
11
A negative modulatory role for rho and rho-associated kinase signaling in delamination of neural crest cells
... all Rho proteins, we next monitored the in vivo effects of inhibiting either RhoA or RhoB ...individual Rho proteins ...mutant Rho constructs were devoid of stress fibers when compared to their ...
22
Original Article Overexpression of Rho/Rho kinase and M
... PLC-β 1 . Recently, the Rho/Rho kinase signaling pathway was suggested to be involved in β 2 -adrenoceptor ...The associated changes in protein and gene expression (RhoA, Rho ...
11
Darapladib, a Lipoprotein Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis
... The terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) technique was used to evaluate apoptotic activity. Myocardial tissues were embedded in paraf- fin and cut into 5-mm thick slices. The ...
7
TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway
... The Rho/Rho kinase pathway also plays an essential role in EC function and angiogenesis by regulating focal adhesion and stress fiber formation during cell migration ...increased ...
13
In-silico and Molecular Analysis of Reticulon 4asNovel therapeutic option for axonal regeneration
... PMP22 duplication/deletion, Mitofusin (MFN2), and Gap junction beta-1 protein (GJB1) were expelled in all patients. Single nucleotide polymorphism (SNP) was also confirmed from 1000 genome browse (Figure-5B). ...
6
Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II
... In order to determine whether Netrin-1 guides BM axon projections, we analysed embryonic day 11.5 (E11.5) mice deficient in Netrin-1 function [19] using whole-mount immunostaining or retrograde axon tracing ...
15