Rho kinase
Inhalation of the Rho-kinase inhibitor Y-27632 reverses allergen-induced airway hyperresponsiveness after the early and late asthmatic reaction
... on Rho-kinase for their contrac- tile effects ...in Rho-kinase activation between such mediators and the inhaled agonists, which results in a higher efficacy of Rho-kinase ...
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Rho kinase/AMPK axis regulates hepatic lipogenesis during overnutrition
... of chronic liver disease and is closely associated with insulin resistance, ultimately leading to cirrhosis and hepatocellular carcinoma. However, knowledge of the intracellular regulators of obesity-linked fatty liver ...
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Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor
... lifespan in culture that limits their proliferative capacity and clinical use. Here, we report that treatment of primary keratinocytes (originating from 3 different anatomical sites) with Y- 27632, a Rho ...
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ER stress and Rho kinase activation underlie the vasculopathy of CADASIL
... and Rho kinase, confirming that Notch3 is an upstream ...genes, Rho kinase activity, and ER stress ...and Rho kinase–mediated functional respons- es are not generalized ...
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Original Article Impacts of Rho kinase inhibitor Fasudil on Rho/ROCK signaling pathway in rabbits with optic nerve injury
... 16], Rho could be activated into Rho-GTP by G protein-coupled ...a Rho kinase present in the central nervous system, belonging to the Ser/Thr protein kinase, and it was an important ...
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Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase
... Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibiti[r] ...
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An emerging treatment option for glaucoma: Rho kinase inhibitors
... Abstract: Rho kinase (ROCK) inhibitors are a novel potential class of glaucoma therapeutics with multiple compounds currently in Phase II and III US Food and Drug Administration trials in the United ...
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Myeloperoxidase aggravates pulmonary arterial hypertension by activation of vascular Rho-kinase
... of Rho-kinase activity, cell supernatants were removed, and PASMCs were snap-frozen in culture dishes, thawed in ice cold lysis buffer (20 mM Tris-HCl [pH ...
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Original Article Effect of the Rho kinase inhibitor Y-27632 and fasudil on inflammation and fibrosis in human mesangial cells (HMCs) under high glucose via the Rho/ROCK signaling pathway
... tion. Rho kinase, that is, ROCK, which is the most well studied downstream factor of Rho, con- sists of an N-terminal kinase domain followed by a central coiled coil-forming region containing ...
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Establishment of the Muscle–Tendon Junction During Thorax Morphogenesis in Drosophila Requires the Rho-Kinase
... Drosophila Rho kinase (DRok) is necessary in tendon cells to assemble stable myotendinous junctions (MTJ), which are required for muscle morphogenesis and ...
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Ocular hypotension, actin stress fiber disruption and phagocytosis increase by RKI-1447, a Rho-kinase inhibitor
... This study investigated the hypotensive effect of RKI-1447, a Rho kinase inhibitor developed for cancer treatment, in a porcine ex vivo pigmentary glaucoma model.. Materials and Meth[r] ...
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The Rho kinase Rock2b establishes anteroposterior asymmetry of the ciliated Kupffer's vesicle in zebrafish
... a Rho kinase gene, rock2b, which was strongly expressed in KV (Thisse et ...implicating Rho-Rho kinase signaling in LR development (Panizzi et ...
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Original Article Bone marrow-derived mesenchymal stem cells alleviates renal injury in severe acute pancreatitis via RhoA/Rho kinase
... RhoA/Rho kinase is activated in ...RhoA/Rho kinase involved in APS, and the specific mechanism of BMSCs in ...RhoA/Rho kinase signaling pathways, increase the ZO-1 expression, ...
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TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway
... the Rho/Rho kinase pathway has become an attractive target in cancer medicine due to its involvement in cellular processes such as proliferation, cell shape, motility, as well as its contribution to ...
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Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood Brain Barrier Leakage in Experimental Viral Encephalitis
... of Rho kinase (ROCK) is hypothesized to initiate cytoskeletal rearrangements that disrupt TJ connections in epithelial cells ...and Rho-GTPases, as well as ROCKs (15, ...of Rho-GTPases and ...
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Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle
... (Rho kinase 1 [ROCK1], Rho kinase 2 [ROCK2], myosin-light chain kinase [MLCK]) as well as three standard reference genes (glyceraldehyde-3-phosphate de- hydrogenase [GAPDH], β-actin ...
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Original Article Overexpression of Rho/Rho kinase and M
... intain some basic cell functions and was not activated by modest inflammatory cell infiltration. In fact, Forstermann and his col- leagues discovered that endothelium-depen- dent vasodilation in healthy subjects tends to ...
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The effect of Rho kinase inhibition on long-term keratinocyte proliferation is rapid and conditional
... Most studies on the role of Rho-associated kinases on keratinocyte proliferation have used Y-27632 to inhibit ROCK [1,6,14]. Y-27632 is a potent inhibitor of ROCK 1 and 2, but it also has some inhibitory effects ...
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RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension
... inflammation. Rho-kinases (ROCKs) are one of the best-described effectors of the small G-protein RhoA, and ROCKs are involved in a variety of cellular functions including muscle cell contraction, proliferation and ...
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Original Article Effect of fasudil on hypoxic pulmonary hypertension and right ventricular hypertrophy in rats
... Abstract: Objective: To investigate whether right ventricular hypertrophy in hypoxic pulmonary hypertension (HPH) rats could be prevented by treatment with Rho kinase inhibitor fasudil. Methods: The rat ...
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