RhoA/ROCK
NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction
... [15]. RhoA mediates not only polymerization of actin (F-actin formation) to generate stress fibers, which are antiparallel actin filaments that are crosslinked by myosin, but also activation of myosin to trigger ...
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Original Article ANXA10 plays a suppressor role by regulating RhoA-ROCK signaling pathway in hepatocellular cancer
... To explore the in vivo role of AN- XA10, SMMC-7721 cells over-ex- pressing ANXA10 were inoculated into nude mice subcutaneously. Then tumor growth was monitor- ed and recorded at designed time points. As shown in Figure ...
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Original Article The RhoA/ROCK signaling pathway affects the development of diabetic nephropathy resulting from the epithelial to mesenchymal transition
... the RhoA activation pathway. Recent studies found that RhoA/ROCK signaling path- way activation is involved in the remodeling of multiple tissue structures [7-9] and plays an important role in the ...
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RhoA/ROCK Signaling Regulates TGFβ-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through MRTF-A
... is ROCK/ MRTF-A-dependent, where both re- mained intact at the cell membrane in the presence of Y-27632 as well as CCG- ...activated RhoA has been shown to mediate disassembly of epithelial cell contacts, ...
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Gankyrin plays an essential role in Ras induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells
... the RhoA GTPase and its GDP dissociation inhibi- tor RhoGDI, which resulted in inhibition of the RhoA effector kinase Rho-associated coiled coil–containing protein kinase ...Gankyrin-mediated ROCK ...
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Effects of Bu Shen Yi sui capsule on NogoA/NgR and its signaling pathways RhoA/ROCK in mice with experimental autoimmune encephalomyelitis
... NgR, RhoA and ROCK mRNA expression in brain and spinal cord of mice were observed by ...GTCCACGACATGAAG-3′; RhoA forward, 5′-GGAGTG TTCAGCAAAGACCAAAG-3′, reverse, 5′-CACAAGA Table 1 The antibodies ...
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Role of a RhoA/ROCK-Dependent Pathway on Renal Connexin43 Regulation in the Angiotensin II- Induced Renal Damage
... the RhoA/ROCK pathway are spontaneously reversible if the increase in AngII last 3 or less ...the RhoA/ROCK pathway, prevents the irreversibility of the evaluated kidney alterations when is ...
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Original Article Muscularization of pulmonary artery and RhoA/ROCK levels in rats exposed to intermittent hypoxia
... Fourth, RhoA/ROCK signal- ling has not only been implicated in mediating sustained, abnormal vascular SMC contraction, but also in several other processes [45, 46], and PCNA levels, which elevated in the S, ...
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Original Article miR-506 regulates cell proliferation and apoptosis by affecting RhoA/ROCK signaling pathway in hepatocellular carcinoma cells
... that RhoA/ ROCK signaling pathway may be involved in the development of ...prototype RhoA and Ras- related C3 botulinum toxin substrate 1 (Rac1), were involved in the regulation of cell polarity, ...
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Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway
... that RhoA and ROCK lie upstream of MAPK/ERK ...activating RhoA in an ERK-dependent fashion. However, in this model, RhoA inhibition also reduced ERK phosphorylation [50] suggesting that the ...
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P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine
... of ROCK participated in cortical spreading de- pression (CSD) [62], which is a critical pathology of mi- ...that ROCK plays a role in ...the RhoA/ROCK ...TNC, RhoA/ ROCK may also ...
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Supervillin promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma in hypoxia via activation of the RhoA/ROCK-ERK/p38 pathway
... reported, ROCK acts as an upstream regulator leading to the activation of MAPKs, including p38, MAPK, and ERK [25, 27, ...active RhoA(V14) significantly increased the activation of ERK1/2 and p38 in ...
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Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility
... In addition to microtubule dynamics, actin filament network remodeling plays a key role in cell polarization and migration. Members of the Rho family of GTPases are critical regulators of actin and microtubule ...
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RhoA and ERK signalling regulate the expression of the transcription factor Nfix in myogenic cells
... that RhoA/ROCK signalling might be involved in embryonic to foetal transition, embryonic myoblasts were treated with the ROCK inhibitor Y27632 (Uehata et ...by ROCK inhibition, we evaluated ...
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Mechanism of regulation of stem cell differentiation by matrix stiffness
... a RhoA-independent manner, as indicated by increasing expression of platelet endothelial cell adhesion molecule-1 and vascular endo- thelial growth factor receptor 2 ...of RhoA activa- tion in cardiac stem ...
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Divergent signaling pathways cooperatively regulate TGFβ induction of cysteine-rich protein 2 in vascular smooth muscle cells
... -induced RhoA and ATF2 activation but not Smad2 phosphorylation. Blocking ROCK activity, the major downstream target of RhoA, abolished ATF2 phosphorylation and CRP2 induction but not Smad2 ...while ...
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Oncogenic role of dysregulated leptin signaling in the pathogenesis of ovarian cancer
... homolog; RhoA/ROCK: Ras homolog gene family, member A/Rho-associated protein kinase; SHLA: Superactive human leptin antagonist; SHP: Src Homology Phosphatase; STAT: Signal transducer and activator of ...
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The role of peptides in bone healing and regeneration: a systematic review
... Synthetic osteogenic growth peptide promotes differentiation of human bone marrow mesenchymal stem cells to osteoblasts via RhoA/ROCK pathway.. Mol Cell Biochem.[r] ...
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Endostatin attenuates PDGF-BB- or TGF-β1-induced HSCs activation via suppressing RhoA/ROCK1 signal pathways
... We have uncovered here a novel mechanism of endostatin to inhibit HSC activation by selectively modulating the RhoA/ROCK pathways. For the limitations, we investigated only the effect of endostatin on ...
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Rohwedder, Ina (2013): Integrin mediated regulation of vascular maturation and atherogenesis. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The RhoA effector ROCK can also directly phosphorylate MLC, but it mainly phosphorylates the myosin phosphatase target subunit 1 (MYPT1) and thus prevents the dephosphorylation of MLC by dislocating MLCP ...
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