Ribosomal protein S6
Abnormal regulation of ribosomal protein S6 kinase by insulin in skeletal muscle of insulin resistant humans
... on ribosomal protein S6 kinase activities in skeletal muscle of insulin-sensitive and insulin- resistant nondiabetic Pima Indians during a 2-h hyperinsulinemic, euglycemic ...subjects, S6 ...
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Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase (S6K1) is mediated by an event other than phosphorylation
... (BVr) ribosomal protein S6 kinase (S6K1), expressed in Sf9 cells described along with other methodological details in Additional file 1 was active towards phosphorylating GST-S6 in confor- ...
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Ribosomal Protein S6 Interacts with the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... The latency-associated nuclear antigen (LANA) is central to the maintenance of Kaposi’s sarcoma-associ- ated herpesvirus (KSHV) and to the survival of KSHV-carrying tumor cells. In an effort to identify interaction ...
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The p60-S6K1 isoform of ribosomal protein S6 kinase 1 is a product of alternative mRNA translation
... Ribosomal protein S6 kinase 1 (S6K1) is a well-known downstream effector of mTORC1 (mechanistic target of rapamycin complex 1) participating primarily in the regulation of cell growth and ...several ...
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Ribosomal Protein S6 Associates with Alphavirus Nonstructural Protein 2 and Mediates Expression from Alphavirus Messages
... nonstructural protein 2 (nsP2) is an essential component of the viral replication complex, it also has critical auxiliary functions that determine the outcome of infection in the ...with ribosomal ...
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Identification of Tudor domain containing 7 protein as a novel partner and a substrate for ribosomal protein S6 kinaseS – S6K1 and S6K2
... ribosomal protein S6 kinases (S6ks) are principal regulators of cell size, growth and ...7 protein (tdrd7), which is a scaffold protein detected in complexes involved in the regulation ...
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The possible role of ribosomal protein S6 kinase 4 in the senescence of endothelial progenitor cells in diabetes mellitus
... RSK4, ribosomal protein S6 kinase 4, is firstly found as an X-linked gene in patients with mental retardation and most abundantly expressed in brain and kidney ...
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Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer
... Ribosomes are important intracellular particles for pro- tein synthesis with the composition of RNA and proteins. Ribosomal protein S6 (rpS6) is one of the components of the 40S ribosomal ...
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DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway
... phosphorylated p53 and the phosphorylated proteins of the class I PI3K-Akt-mTOR-ribosomal protein S6 (rpS6) signalling pathway were detected with Western blot analysis. Cellular distribution of DRAM1 ...
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Original Article Clinicopathological significance of ribosomal protein S6 kinase A6 in lung squamous cell carcinoma: an immunohistochemical and RNA-seq study
... Abstract: Ribosomal protein S6 kinase A6 (RPS6KA6) is a downstream factor of the ERK-MAPK pathway and has been extensively studied in various types of ...the ribosomal protein S6 ...
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Elucidation of signaling pathways regulating ribosomal protein S6 kinases
... Having established and characterized this cellular model we have initiated studies on the regulation o f gene expression by ribosomal S6 kinases. The profile o f newly translated proteins in the parental ...
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A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response
... characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pathogenic C-terminal tau fragment (Tau35) that is associated with human tauopathy. ...
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Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucine through an mTORC1-dependent pathway
... including protein synthesis ...substrates, ribosomal protein S6 kinase 1 (S6K1) and eukaryotic initiation factor (eIF) 4E-binding protein-1 ...for ribosomal protein ...
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MiR-199a-modified exosomes from adipose tissue-derived mesenchymal stem cells improve hepatocellular carcinoma chemosensitivity through mTOR pathway
... distinct protein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2, which regulate different cellular pro- ...are ribosomal protein S6 kinase (70S6K) and eukaryotic translation initiation ...
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A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases
... interacting protein kinase (HIPK) 2 and 3, I-kappa B Kinase (IKK), mitogen-activated pro- tein kinase 1 (MAPK2/ERK2), ribosomal protein S6 kinase, 90 kDa, polypeptide 1 and 3 (MAPKAP-K1a/RSK1 ...
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p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer
... of ribosomal protein S6 (rpS6), led to the purification of an intracellular kinase that phos- phorylated 40S ribosomal subunit from unfertilized Xenopus laevis eggs by Erikson and Maller ...
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Regulation of signalling circuitry downstream of mTORC1(mammalian target of Rapamycin)
... of ribosomal protein S6 (rpS6) (another downstream arm of mTOR) by mTOR does not decrease the rate of tumorigenesis and thus supports the primary role of the 4EBP1/eIF4E axis in cancer formation ...
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3D-QSAR, molecular docking and dynamics simulation of difluorophenol pyridine derivatives as RSK2 inhibitor
... The p90 ribosomal S6 kinases (RSK) is a serine/threonine kinase consisting of four closely related isoforms, i.e., RSK1, RSK2, RSK3, and RSK4; all of which have N-terminal kinase domain (NTKD), a conserved ...
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Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity
... the protein levels and activity of Rsk1 and Rsk2, the two isoforms with higher expression levels [1], are modified in the presence of ...striatal protein levels and activity of Rsk in knock-in mhtt mouse ...
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The Proximity of Ribosomal Protein Genes to oriC Enhances Vibrio cholerae Fitness in the Absence of Multifork Replication
... ria, ribosomal protein genes (RP) locate near the replication origin ...many ribosomal components, in the context of a crowded cytoplasm, may favor ribosome ...
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