Rifampicin Resistance
Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell–cell interactions
... Variation of mutation rate at a particular site in a particular genotype, in other words mutation rate plasticity (MRP), can be caused by stress or ageing. However, mutation rate control by other factors is less well ...
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Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell–cell interactions
... Variation of mutation rate at a particular site in a particular genotype, in other words mutation rate plasticity (MRP), can be caused by stress or ageing. However, mutation rate control by other factors is less well ...
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Xpert MTB/RIF and Xpert MTB/RIF Ultra for pulmonary tuberculosis and rifampicin resistance in adults
... normal, rifampicin-susceptible, ‘wild type’ sequence of the rpoB gene of ...of rifampicin-susceptible tu- ...detected, rifampicin resistance detected’; ‘tuberculo- sis detected, no ...
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Is Xpert MTB/RIF appropriate for diagnosing tuberculous pleurisy with pleural fluid samples? A systematic review
... As the first step, two investigators (ZY.Huo and L.Peng) independently screened for articles containing the defined items in the title and abstract. All articles reporting the performance of Xpert MTB/RIF in diag- nosing ...
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Prevalence of Rifampicin Resistance and Associated Risk Factors among Suspected Multidrug Resistant Tuberculosis Cases in TB Centers Mogadishu Somalia: Descriptive Study
... Multidrug-resistant tuberculosis (MDR-TB) is a form of TB caused by bacteria that do not respond to, at least, isoniazid and rifampicin, the two most powerful, first-line (or standard) anti-TB drugs. ...
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Identification and characterization of genetic determinants of Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis in Southern India
... D435Y and D435V. The wildtype residue D435 is located within 3.1 Å and forms a salt bridge with R448 and R607 (Fig. 6A). It also forms a weak hydrogen bond with R607 and rifampicin, and hydrophobic interactions ...
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High dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis : a multi arm, multi stage randomised controlled trial
... diagnosed, rifampicin-sensitive, previously untreated pulmonary tuberculosis were randomly assigned in a 1:1:1:1:2 ratio to receive (all orally) either 35 mg/kg rifampicin per day with 15–20 mg/kg ...
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Rapid screening of MDR TB using molecular Line Probe Assay is feasible in Uganda
... with rifampicin and isoniazid ...of rifampicin resistance (≥97% and ≥99%) and isoniazid resistance (≥90% and ≥99%) on culture isolates and smear-positive ...
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Correlation of Clinical, Radiological, Microbiological Features and Drug Resistance Pattern of Mycobacterium Tuberculosis in Patients with HIV Tuberculosis Co-Infection
... as rifampicin resistance among HIV-infected patients with clinical suspicion of TB 29 ...detected rifampicin resistance with ...excluded resistance with 100 per cent specificity 30, 31 ...
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Rifampicin resistance mutations in the 81 bp RRDR of rpoB gene in Mycobacterium tuberculosis clinical isolates using Xpert MTB/RIF in Khyber Pakhtunkhwa, Pakistan: a retrospective study
... and rifampicin [1]. Rifampicin (RIF) resistance is of specific epidemiological importance and a valuable sur- rogate marker for MDR-TB strains as more than 90 % RIF resistant strains are also ...
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Molecular Detection of Rifampicin Resistance in Mycobacterium Tuberculosis.
... Real time PCR techniques have also been introduced for rapid detection of drug resistance. Different probes have been used like the TaqMan probe, fluorescence resonance energy transfer (FRET) probes, molecular ...
102
Low Doses of Rifampicin Used in New Tuberculosis Patients Correlated to Increased Frequency of Rifampicin Resistance and Poorer Treatment Outcomes
... of rifampicin (15 mg/kg/day and 20 mg/kg/day) to shorten treatment for tuberculosis without causing more adverse events ...standard rifampicin dosage (10 mg/kg/day) was too low, and a rifampicin ...
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Original Article Genome-wide DNA methylation and transcriptome changes in Mycobacterium tuberculosis with rifampicin and isoniazid resistance
... The Rv2386c gene encodes a protein of the large subunit of anthranilate synthase and shows to be essential for the in vitro growth of M. tuberculosis [31]. Our results help to describe the function of Rv2386c, which can ...
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Original Article Genome-wide SNP and InDel mutations in Mycobacterium tuberculosis associated with rifampicin and isoniazid resistance
... and rifampicin lead to the majority of death associated with ...or rifampicin for ...with rifampicin or ...drug resistance were detected in ...and rifampicin resistance were ...
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The occurrence and frequency of genomic mutations that mediate Isoniazid and Rifampicin resistance in Mycobacterium tuberculosis isolates from untreated pulmonary Tuberculosis cases in urban Blantyre, Malawi
... TB resistance originates in the course of treatment due to genomic mutations in Mycobacterium tuberculosis ...and Rifampicin (RIF) resistance among isolates from untreated TB cases in urban Blantyre, ...
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Extensively drug resistant tuberculosis in Mali: a case report
... rifampicin resistance (RR) among smear positive new patients [1]. In Mali, after the first GeneXpert machine was installed in March 2014, another eight have since been installed throughout the country. ...
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Factors associated with isoniazid resistant tuberculosis among human immunodeficiency virus positive patients in Swaziland: a case control study
... and rifampicin resistance. If MTB positive and ri- fampicin resistance not detected, the patient is assumed to be having drug susceptible TB (DS-TB), then the pa- tient is initiated on DS-TB ...and ...
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Artesunate potentiates antibiotics by inactivating heme harbouring bacterial nitric oxide synthase and catalase
... matization, triangle bottles with the bacterial culture were placed without agitation for 3 d at room tempera- ture (the hypoxia group) or in a 4°C refrigerator (the hypoxia + cold group). For antibiotic exposure, a 1% ...
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A Study of Drug Resistance TB among patients with New Sputum Smear Positive Pulmonary Tuberculosis
... INH resistance is by mutationat of catalyse – peroxidase gene so that bacilli do not generate active metabolite of ...INH resistance may also involve mutation in the target inh A ...INH resistance ...
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Use of GeneXpert Mycobacterium tuberculosis /rifampicin for rapid detection of rifampicin resistant Mycobacterium tuberculosis strains of clinically suspected multi drug resistance tuberculosis cases
... Multi-drug resistance (MDR) TB is defined as TB disease caused by a strain of ...and rifampicin (RIF) ...drug resistance causing gene muta-tions ...RIF resistance and MDR TB, this technique ...
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