RIG-I-like receptors
C-type lectin receptors and RIG-I-like receptors: new points on the oncogenomics map
... recognition receptors includes families of Toll-like receptors, NOD-like receptors, C-type lectin receptors, and RIG-I-like ...these receptors and ...
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Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss)
... gene I (RIG-I)-like receptors (RLR) comprise three homologues: RIG-I, mela- noma differentiation-associated gene 5 (MDA5), and laboratory of genetics and physiology 2 ...
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MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors
... HEK293T or HeLa cells were infected with SeV WT or H4, and at various times after infection RIG-I, MAVS, p-IRF3, IRF3, p-I B a and I B a were analyzed in cell extracts by immunoblottin[r] ...
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Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL 33
... In summary, in this study we demonstrate BSMC pro- duction of the immunoregulatory cytokine IL-33, which has been forwarded as a potential disease factor in asthma. Further, we show that conditioned media from bronchial ...
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Importance of innate mucosal immunity and the promises it holds
... Abstract: The body defense mechanism has evolved to protect animals from invading pathogenic microorganisms and cancer. It is able to generate a diverse variety of cells and molecules capable of specifically recognizing ...
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Mitophagy Enhances Oncolytic Measles Virus Replication by Mitigating DDX58/RIG-I-Like Receptor Signaling
... The success of future clinical trials with oncolytic viruses depends on the identification and the control of mechanisms that mod- ulate their therapeutic efficacy. In particular, little is known about the role of ...
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The Z Proteins of Pathogenic but Not Nonpathogenic Arenaviruses Inhibit RIG-i-Like Receptor-Dependent Interferon Production
... the RIG-i-like receptors (RLRs) by pathogenic Z proteins is mediated by the protein-pro- tein interactions of Z and RLRs, which lead to the disruption of the interactions between RLRs and ...
13
RIG I is responsible for activation of type I interferon pathway in Seneca Valley virus infected porcine cells to suppress viral replication
... recognition receptors (PRRs) including Toll-like receptor (TLRs), RIG-I-like receptor (RLRs), nucleo- tide oligomerization domain-like receptor (NLRs) and cytosolic DNA sensors ...
9
RIG-I-Like Receptor and Toll-Like Receptor Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in a Severe Fever with Thrombocytopenia Syndrome Virus Infection Mouse Model
... regulates RIG-I signaling by competing with RIG-I to recognize double-stranded RNA (dsRNA) ...its receptors (58) is potentially beneficial for SFTS ...corticoid receptors, and the ...
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Enhanced Influenza Virus-Like Particle Vaccination with a Structurally Optimized RIG-I Agonist as Adjuvant
... recognition receptors (PRRs), includ- ing the cell surface- and endosome-associated TLRs or the cyto- solic RIG-like receptors, is an attractive target for the development of vaccine adjuvants ...
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USP4 Positively Regulates RIG-I-Mediated Antiviral Response through Deubiquitination and Stabilization of RIG-I
... ype I interferons (IFN- ␣ and IFN-  ) possess strong antiviral activity and play pivotal roles in defense against viral infection (1, ...pattern-recognition receptors (PRRs), including Toll-like ...
9
Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA
... recognition receptors (PRRs), such as retinoic acid-induced gene I (RIG-I) and melanoma differentiation gene 5 (MDA5), in the cytoplasm ...recognition, RIG-I and MDA5 are ...
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Hsieh, Chin-Yuan (2012): Analysis of Toll-like receptors and retinoic-acid-inducible gene-I (RIG-I)-like helicases in human neutrophils and HL60 cells. Dissertation, LMU München: Medizinische Fakultät
... In the study of Hornung et al, 3pRNAwas reported as a potent inducer of IFN-α in human monocytes. They used in vitro transcription to generate a dsRNA oligonucleotide with an overhang of one nucleotide at the 5' ...
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Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells
... Toll-like receptors (TLRs) located at the cell surface and within endosomes or the retinoic acid-inducible gene I (RIG-I)-like helicases (RLHs) detecting nucleic acids within the ...
7
Differential expression of viral PAMP receptors mRNA in peripheral blood of patients with chronic hepatitis C infection
... Toll-like receptors have been related with the recognition and interferon-mediated response against viruses [21-24] showing that they play a key role in the innate response against viral ...links ...
6
Mismatches in the Influenza A Virus RNA Panhandle Prevent Retinoic Acid-Inducible Gene I (RIG-I) Sensing by Impairing RNA/RIG-I Complex Formation
... vivo RIG-I binding. 293T cells were first transfected with pEF-Bos-RIG-I (2 g) for 24 h and then transfected with 2 g of biotinylated perfect cRNA ...RNA-bound RIG-I. ...
5
Phosphorylation of RIG-I by Casein Kinase II Inhibits Its Antiviral Response
... by RIG-I are implicated in host de- fense against pathogens via stimulation of alpha/beta inter- feron (IFN- ␣ /  ) production and downstream transcription of various antiviral genes ...cells, ...
12
Andreeva, Liudmila (2018): Cytosolic DNA sensing via cGAS: long, U-shaped and other DNA ligands and cellular co-factors. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... different reaction compositions, cGAS constructs and DNA-ligands in a large-scale format and is suitable for a broad range of conditions. Furthermore, fATP used in this method is commercially available and no specialized ...
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NOD like receptors and inflammation
... NOD-like receptors, both abbreviated to NLR) family of intracellular pathogen recognition receptors are increasingly being recognized to play a pivotal role in the pathogenesis of a number of rare ...
14
Deregulation of innate and adaptive immune responses in human papillomavirus infection and cancer
... contained cancer-related genes including tumor-promoting cyto- kines/chemokines and their receptors, e.g. CXCR7, of which the expression was higher in HPV-positive KCs irrespective of poly(I:C) stimulation. Many ...
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