RIG-I signaling pathway
Inhibition of RIG-I-Dependent Signaling to the Interferon Pathway during Hepatitis C Virus Expression and Restoration of Signaling by IKKε
... IFN signaling via TRIF-dependent and TRIF-independent ...IFN signaling was examined by analyzing the effect of NS3/4A on the TRIF adaptor, an essential component of the TLR3-double-stranded RNA-dependent ...
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Negative Regulation of RIG-I-Mediated Innate Antiviral Signaling by SEC14L1
... with RIG-I and regulate its signaling, we performed a yeast two-hybrid screen using RIG-I as a ...of RIG-I (16) and ARF-like protein 16, which inhibits RIG-I ...
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Respiratory Syncytial Virus-Mediated NF-κB p65 Phosphorylation at Serine 536 Is Dependent on RIG-I, TRAF6, and IKKβ
... in RIG-I-siRNA-transfected cells, and to a lesser extent by ...different signaling path- ways, the specific involvement of RIG-I and MDA-5 in p65Ser536 phosphorylation-dependent NF- B ...
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RIG-I Signaling Is Essential for Influenza B Virus-Induced Rapid Interferon Gene Expression
... are RIG-I, MDA5, TLR3, TLR7, and ...endosomal pathway, where TLR3, -7, and -8 are localized, viral entry could be recognized in the endo- ...p-IRF3, I B ␣ , and influenza B virus NP ...
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Porcine Deltacoronavirus Accessory Protein NS6 Antagonizes Interferon Beta Production by Interfering with the Binding of RIG-I/MDA5 to Double-Stranded RNA
... gene I (RIG-I) and melanoma differentiation gene 5 (MDA5), in the cytoplasm ...recognition, RIG-I and MDA5 are activated, resulting in the recruitment of mitochondrial antiviral ...
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Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5
... type I inter- feron during the cellular interferon-inducible antiviral ...to RIG-I and MDA-5 and inhib- its downstream activation of the RLR signaling pathway, prevent- ing the ...
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Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity
... of RIG-I signaling during influ- enza virus infection, we conducted IFN-  promoter signaling experiments in HeLa cells and in Huh7 cell ...down RIG-I or IPS-1 expression. As ...
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Inhibition of RIG-I-Mediated Signaling by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Deubiquitinase ORF64
... of RIG-I with its downstream signaling partner MAVS/VISA/IPS-1/Cardif, which ultimately leads to RIG-I-mediated IFN responses (15, ...block RIG-I function, ORF64 was ...
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Adenovirus Virus-Associated RNAs Induce Type I Interferon Expression through a RIG-I-Mediated Pathway
... RNA I (VAI) and VAII, 157 and 158 nucleotides in length, respectively, are short noncod- ing RNAs transcribed by RNA polymerase III and expected to form dsRNA-like secondary structures ...gene I ...
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Classical swine fever virus triggers RIG I and MDA5 dependent signaling pathway to IRF 3 and NF κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages
... the RIG- I-like receptors (RLRs) ...initiate signaling pathways that can lead to the activation of transcription factors NF-kB and the IRF-3 and IRF-7 [3], which often culminate in the induction of ...
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The RIG I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis
... (Cell Signaling Tech- nology, Danvers, MA, USA), anti-Fas (Abcam, Cambridge, UK), anti-cleaved caspase 3 (Cell Signaling Technology, USA), and anti-β-actin (Sigma, St Louis, MO, ...
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MAVS Dimer Is a Crucial Signaling Component of Innate Immunity and the Target of Hepatitis C Virus NS3/4A Protease
... recruit signaling inter- mediates that activate IRF3 and NF- ...that RIG-I is overexpressed about ninefold in HCV-infected chim- panzees (5), a phenomenon that could lead to constitutive ...
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RIG I is responsible for activation of type I interferon pathway in Seneca Valley virus infected porcine cells to suppress viral replication
... (TLRs), RIG-I-like receptor (RLRs), nucleo- tide oligomerization domain-like receptor (NLRs) and cytosolic DNA sensors [11, ...viral signaling induces the expression of interferons (IFNs), ...
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RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I
... the RIG-I sensor in the recognition of incoming virus RNA structures (76); an understanding of the evasion strategies used by viruses to circumvent this crucial antiviral response is an important step in ...
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Coexpressed RIG-I Agonist Enhances Humoral Immune Response to Influenza Virus DNA Vaccine
... ent signaling pathways could be determined by vaccination of homozygous knockout ...dsRNA43 RIG-I ligand may be more potent than convergent eRNA11a for induction of cellular ...receptor ...
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Pathogen-Associated Molecular Pattern Recognition of Hepatitis C Virus Transmitted/Founder Variants by RIG-I Is Dependent on U-Core Length
... that RIG-I recognition of HCV is de- pendent on a poly-uridine/cytosine-rich motif found in the 3= untranslated region (3= UTR) (1, ...ablates RIG-I recognition of the pU/UC motif as a PAMP, ...
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Activation and Antagonism of RIG-I-Mediated Innate Immune Signaling by Herpes Simplex Virus 1
... downstream signaling (Figure ...sensing pathway of cytoplasmic viral DNA (Ishikawa et ...promoting RIG-I signal transduction (Ishikawa and Barber, 2008; Zhong et ...the signaling-active ...
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Brfl Post-Transcriptionally Regulates Pluripotency and Differentiation Responses Downstream of Erk MAP Kinase
... of signaling to disrupt the regulation of Nanog expression (Figure ...kinase signaling independently regulate Nanog protein levels on a much faster ...
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Identification of COX5B as a novel biomarker in high-grade glioma patients
... oncogenic pathway activation in glioma, from the Gene Expression Omnibus ...(MAPK signaling pathway, Wnt signaling pathway, and ErbB signaling pathway) deregulated in the ...
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In silico identification of potential key regulatory factors in smoking-induced lung cancer
... Lung cancer is a complex and highly heterogeneous di- sease involving multiple signaling pathways [1]. It is the leading cause of cancer mortality in men and the second leading cause in women worldwide [2]. Small ...
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