ROCK/Rho-kinase
Original Article Effect of the Rho kinase inhibitor Y-27632 and fasudil on inflammation and fibrosis in human mesangial cells (HMCs) under high glucose via the Rho/ROCK signaling pathway
... tion. Rho kinase, that is, ROCK, which is the most well studied downstream factor of Rho, con- sists of an N-terminal kinase domain followed by a central coiled coil-forming region ...
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Original Article Impacts of Rho kinase inhibitor Fasudil on Rho/ROCK signaling pathway in rabbits with optic nerve injury
... 16], Rho could be activated into Rho-GTP by G protein-coupled ...receptors. Rock 2 was a Rho kinase present in the central nervous system, belonging to the Ser/Thr protein ...
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Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context
... of ROCK inhibition on the phenotype of MDA- MB-231 cells. Expression of ROCK protein was not changed by overexpression of E-cadherin (Figure ...of ROCK led to less disorganized phenotype (Figure 10A, ...
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RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension
... inflammation. Rho-kinases (ROCKs) are one of the best-described effectors of the small G-protein RhoA, and ROCKs are involved in a variety of cellular functions including muscle cell contraction, proliferation and ...
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Inverse relationship of Rho kinase and myosin-light chain kinase expression in the aging human detrusor smooth muscle
... of ROCK and MLCK inhibition, respectively ...predominant Rho kinase isoform in the human de- trusor is ...since Rho kinase inhibitors are currently developed for different potential ...
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Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood Brain Barrier Leakage in Experimental Viral Encephalitis
... through ROCK in brain endothelial ...(black), ROCK inhibitor Y-27632 (ROCKi; light gray), Rhosin (dark gray), IFN- ␥⫹ ROCKi (light gray and black stripes), and IFN- ␥⫹ Rhosin (dark gray and black stripes) ...
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Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy
... in ROCK-1 expression? One possibility is that secretory factors produced by adipose tissue of overweight and obese women may alter the myometrial ...RhoA/Rho kinase signalling in contractile activity ...
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An emerging treatment option for glaucoma: Rho kinase inhibitors
... Another promising ROCK inhibitor designed for glaucoma therapy is AR-13324, developed by Aerie Pharmaceuticals Inc., (Research Triangle Park, NC, USA) and expected to commence Phase III clinical trials soon. ...
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Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor
... Y-27632, a well-characterized inhibitor of the Rho-associated kinase, ROCK (16). As shown in Figure 1, in the absence of Y-27632, the growth rate of all 3 keratinocyte types slowed with time, and ...
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Neuronal polarization
... of Rho kinase (ROCK), a downstream effector protein of RhoA, also enhances axonal elongation and induces the formation of multiple axons (Da Silva et ...2003). Rho kinase phosphorylates ...
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The evolutionary history of effectors downstream of Cdc42 and Rac
... (a Rho function) as well as cytokinesis and Rho-medi- ated transcriptional activation of the serum response factor ...for Rho- family GTPases that, like Paks, mediate both cytoskeletal and ...
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Mechanical control of tissue and organ development
... and Rho/Rho-associated kinase (ROCK) signaling pathways, stabilize the junctions and drive cell ...and Rho/ROCK signaling pathways might help to drive tissue closure; underlying ...
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Mühlhoff, Marei (2004): Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen. Dissertation, LMU München: Tierärztliche Fakultät
... letzten Jahren wurden zahlreiche Zielproteine von PA in vitro identifiziert, aber nur bei einigen konnte auch eine Aktivitätsteigerung in vivo belegt werden. Dass die Stimulation der PIP-5-kinase durch die PLD ...
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Regulation of epithelial morphogenesis by Drosophila Rho GTPase and Abl kinase
... I evaluated the role of the small GTPase Rho1 as an adherens junction regulator in Drosophila and determined whether, as in cultured mammalian cells, Drosophila Rho1 is regulated by the [r] ...
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HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells
... and ROCK as host dependency factors for viral ...upon Rho family GTPase signaling for optimal infection of target cells is not unique to HIV-1 infection: adenovirus [56], Kaposi’s sarcoma herpesvi- rus [57, ...
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Role of osteopontin in bone remodeling and orthodontic tooth movement: a review
... OPN binds to several integrins including αvβ3, αvβ5, αvβ1, α4β1, α5, and α9β1. OPN binding to αvβ3 is crucial for major post-receptor signal responses, which involves regulation of osteoclastic activity and activation of ...
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ER stress and Rho kinase activation underlie the vasculopathy of CADASIL
... Human VSMC isolation. Methods for the isolation and culture of human VSMCs have been previously described (57). Briefly, cleaned arteries were placed in Ham’s F-12 culture medium containing 1% gentamicin, collagenase ...
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Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling
... the Rho/ ROCK-dependent amoeboid mode of invasion as their primary invading ...of Rho/ROCK signaling results in an increased invasion into Matrigel associated with the increased activation of ...
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TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway
... basal Rho activity, which controls the actin cytoskeleton, contributes to the abnormal mechanosensing ability of TEC, and that TRPV4 activation and/or overexpression can restore Rho activity to that ...
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Mechanism of regulation of stem cell differentiation by matrix stiffness
... The endothelial cell differentiation of cardiac stem cells is induced by matrix stiffness replicating that of the myocardium (12 to 16 kPa) in a RhoA-independent manner, as indicated by increasing expression of platelet ...
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