Role for TACC3 in interphase cell migration
High expression of TACC3 in esophageal squamous cell carcinoma correlates with poor prognosis
... growth-promoting role of TACC3 in ESCC cells. TACC3 silencing inhibited ESCC cell migration To verify the correlation between TACC3 and metastasis in ESCC cell lines, the ...
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FGFR3–TACC3 cancer gene fusions cause mitotic defects by removal of endogenous TACC3 from the mitotic spindle
... a TACC3-specific role of FT3 in inducing mitotic defects in bladder cancer ...of TACC3 levels at the mitotic spindle, and mitotic defects will still be present in these ...prevents TACC3 ...
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Aberrations of TACC1 and TACC3 are associated with ovarian cancer
... the TACC3 gene in familial ovarian cancer The prevalence of structural aberrations in 4p16 noted during ovarian tumorigenesis indicates that this region could contain one or more genes whose normal role is ...
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Physical role for the nucleus in cell migration
... physical role of the nucleus in eukaryotic cell migration. The role of the nucleus has been largely neglected, partly due to the famous experiments of kerat- ocyte cell fragments ...
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The role and regulation of blebs in cell migration.
... global cell mechanics without describing the underlying molecular details [16,31 ,37 ,38,39]; and molecular models that use computer simulations to derive cell-scale beha- viors from microscopic ...
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The Role of the Exocyst in Exocytosis and Cell Migration
... The Role of the Exocyst in Exocytosis and Cell Migration Abstract The exocyst, an evolutionarily conserved octameric protein complex, plays a crucial role in the tethering of post-Golgi ...
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The Role of the GTPase Rho in T cell Adhesion and Migration
... T cell function (Gomez et ...pre-T cell differentiation and can potentiate proliferative responses in pre-T ...T cell differentiation and proliferation (Corre et ...pre-T cell ...
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The Role of the Exocyst in Membrane Deformation, Cell Migration and Exocytosis
... The membrane-deformation function of Exo70 is likely to be independent of the other exocyst subunits. Exo70 thus represents a novel membrane-deforming protein for plasma membrane remodeling. Directional cell ...
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The Role of Stroma Microenvironments in Prostate Cancer Cell Migration and Metastasis
... Mesenchymal stromal cell lines including the bone marrow stromal cell (BMSC) line and mesenchymal stromal cells (MSCs) will allow for in vitro and in vivo studies.. of strom[r] ...
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The role of focal adhesion kinase in vascular smooth muscle cell migration
... ruffling, cell spreading, microtubule stability, or organization of the actin cytoskeleton, all of which have been described in fibroblasts and keratinocytes 20 ...of cell type as a determinant of FAK ...
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
... peptide, and a YFP variant (cpVE172) [32]. The difference is that an inactive confor- mation is characterized by separated fluorescent proteins, rather than proximal ones. Once AMPK phosphorylates the AMPK substrate ...
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The role of SH3GL3 in myeloma cell migration/invasion, stemness and chemo-resistance
... Most of myeloma therapies take advantage of the key features of malignant myeloma cells, such as fast proliferation rate and sensitivity to certain therapeutic drugs, or disrupting signaling pathways and ...
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Role of the ABC transporter Mdr49 in Hedgehog signaling and germ cell migration
... Because of the reported involvement of the mammalian Mdr1/P- cg1 transporter in cholesterol translocation, we wondered whether Mdr49 might be required to ensure that there are sufficient levels of cholesterol in the SGPs ...
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Evidence for a role of collagen synthesis in arterial smooth muscle cell migration
... 4-hydroxylase, do not become hydroxylated (29). Both types of agents have been shown to markedly impair the secretion of functional collagen (27, 29, 30). In this study, we have used both classes of collagen synthe- sis ...
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A Novel Role of Cab45-G in Mediating Cell Migration in Cancer Cells
... important role in protein sorting and secretion at Golgi complex. However, its role in cancer cell migration remains ...in cell lines with higher metastatic potential and promoted ...
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Elucidating the role of mTOR kinase in chronic lymphocytic leukaemia cell migration
... stromal cell co-culture, CLL cells demonstrate increased BCL-2 and increased BCL2A1, both of which offer relative resistance to BCL-2 inhibition in ...key role in protecting the CLL cells from oxidative ...
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Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration
... Background Cell migration is a highly complex process that is involved in various biological processes ranging from embryonic development to the immune response ...important role in metastasis and ...
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Role of mithocondrial Ca2+ uptake in breast cancer cell migration and invasiveness
... 67 commonly accepted as critical triggers of metastatic progression, both in vitro and in vivo (Porporato et al., 2014), in agreement with the observation that, also in our model, antioxidant treatments (in particular ...
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The role of mir-382-5p in glioma cell proliferation, migration and invasion
... The role of miR-382-5p in glioma cell growth and progression has not been ...glioma cell proliferation, migration, invasion, and epithelial to mesenchymal transition ...the role of ...
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Time lapse and cell ablation reveal the role of cell interactions in fly glia migration and proliferation
... dynamic cell shape remodelling allows glia to polarise along the underlying axon during migration and ...time-lapse, cell ablation and genetic manipulation has enabled us to identify the contribution ...
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