ROOT GANGLION NEURONS
Anterograde Transport of Herpes Simplex Virus Type 1 in Cultured, Dissociated Human and Rat Dorsal Root Ganglion Neurons
... dorsal root ganglion neurons. The neurons were infected with HSV-1 to examine the distribution of capsid (VP5), tegument (VP16), and glycoproteins (gC and gB) at 2, 6, 10, 13, 17, and 24 h ...
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In Rat Dorsal Root Ganglion Neurons, Herpes Simplex Virus Type 1 Tegument Forms in the Cytoplasm of the Cell Body
... dorsal root ganglion neurons was examined by immunoelectron ...of neurons, most tegument proteins are incorporated into unen- veloped nucleocapsids prior to envelopment in the Golgi and the ...
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Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons
... dorsal root ganglion neurons and caused a significant increase in the amplitude of the depolarization and the number of spikes induced by acid ...
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Monoarticular antigen induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats
... SP–gold-labelled neurons in immunized animals without knee injection (n = 3) was ...DRG neurons exhibited labelling with SP–gold, and this was seen both on the side of the injected knee and on the opposite ...
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Dexmedetomidine inhibits Tetrodotoxin-resistant Nav1.8 sodium channel activity through Gi/o-dependent pathway in rat dorsal root ganglion neurons
... the majority of TTX-R currents. Accumulating evidence points up that TTX-R sodium channel plays an important role in peripheral pain processing [27]. Nociceptive signals evoke a dynamic change of TTX-R sodium channel, ...
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Ultrastructural Visualization of Individual Tegument Protein Dissociation during Entry of Herpes Simplex Virus 1 into Human and Rat Dorsal Root Ganglion Neurons
... pUL37, during HSV-1 entry in human and rat DRG axons and cell bodies of neurons. pUL36 was the main tegument protein dem- onstrated by TIEM to remain associated with incoming capsids despite undergoing partial ...
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An investigation into the role of the hyperpolarisation-activated cyclic nucleotide-gated on channels in dorsal root ganglion neurons in rat models of chronic inflammatory and neuropathic pain
... Using!animal!models!of!chronic!pain!{CP},!which!included!the!complete!Freund’s! adjuvant! {CFA}! model! of! hindlimb! inflammation! and! the! surgically! induced! modified! spinal! nerve! axotomy! {mSNA}! model! of! ...
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Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading
... Early signaling events were only detected in loaded bones. Similarly, the pattern of bone sig- naling and DRG neuron gene expression was similar between right and left limbs of individual animals for all pathways and ...
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GTP-dependent run-up of Piezo2-type mechanically activated currents in rat dorsal root ganglion neurons
... dorsal root ganglion (DRG) neurons in culture by using the whole-cell patch- clamp recording ...DRG neurons, rapidly adapting (RA) and slowly adapting currents (SA) ...
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TNF-α mediated upregulation of NaV1.7 currents in rat dorsal root ganglion neurons is independent of CRMP2 SUMOylation
... the neurons were transferred to a supplemented F12 culture medium (B27 (2%), L-glutamine (1%), N2 (1%) and NGF ...DRG neurons were then distributed into a 24-well plate containing coverslips pretreated with ...
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Role of Nuclear Factor-κB in Oxidative Stress Associated with Rabies Virus Infection of Adult Rat Dorsal Root Ganglion Neurons
... dorsal root ganglion (DRG) neurons infected with the chal- lenge virus standard-11 strain of rabies virus (CVS) showed axonal swellings and immunostaining for 4-hydroxy-2-nonenal (4- HNE), indicating ...
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CC chemokine ligand 2 upregulates the current density and expression of TRPV1 channels and Nav1.8 sodium channels in dorsal root ganglion neurons
... CCL2 activation of CCR2 has been shown to produce various cellular responses via two signal transduction pathways, the PI3K/Akt and ERK 1/2 cascades [45-48]. LY294002, a specific PI3K inhibitor [49,50], was used to test ...
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Characterization of temperature-sensitive leak K+ currents and expression of TRAAK, TREK-1, and TREK2 channels in dorsal root ganglion neurons of rats
... DRG neurons innervating the mouse ...sensory neurons in colitis ...in neurons of L5 dorsal root ganglions of ...DRG neurons and the patch-clamp recording technique, temperature ...
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Opiate mediated inhibition of calcium signaling is decreased in dorsal root ganglion neurons from the diabetic BB/W rat
... DRG neurons were inhibited by Dyn A at concentra- tions of 1, 3, and 5 mM by 1863% (n 5 6), 2564% (n 5 5), and 3767% (n 5 3), respectively ...DRG neurons from diabetic animals demonstrated signifi- cantly ...
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Morphological Identification of Cell Death in Dorsal Root Ganglion Neurons Following Peripheral Nerve injury and repair in adult rat
... sensory neurons retain their ability to regenerate for at least 8 weeks after nerve injury [36] but early [16] and delayed [36] reconstruction of injured with peripheral nerve grafting fail to rescue ...
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The Role of Growth-Associated Protein-43 (GAP-43) and Superior Cervical Ganglion-10 (SCG-10) mRNA and Protein Levels in Dorsal Root Ganglion Neurons of Lumbar Spinal Cord Segments (L4-L5) Associated with Sciatic Injured Nerve
... sensory neurons triggered various cellular mechanisms significant for the structural and functional integrity of neurons and protective against oxidative ...sensory neurons of embryos, upregulation ...
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Pharmacological evaluation of rat dorsal root ganglion neurons as an in vitro model for diabetic neuropathy
... the neurons to the isolation procedure, we undertook an RT-PCR analysis of whole-mounted DRGs for the stress-related genes, ATF3, c-jun, and ...DRG neurons isolated from diabetic rats when compared with ...
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Herpes Simplex Virus Type 1 Vector-Mediated Expression of Nerve Growth Factor Protects Dorsal Root Ganglion Neurons from Peroxide Toxicity
... Cells. African green monkey kidney (Vero) cells (ATCC CCL-81) and the ICP4-complementing cell line derivative of Vero cells, E5 (17), as well as mouse N2A neuroblastoma (ATCC CCL-131), rat B103 neuroma (105), and rat 9L ...
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Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret
... of neurons expressing Isl1, GFP, Gfra1 and Gfra2 per ganglion, we prepared five adjacent sets of 12- m sections from L4 and L5 DRG from three ...of neurons labeled with each marker, Isl1 staining ...
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Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult <em>Bax</em>-deficient mice
... more neurons in contralateral DRGs of KO mice as compared with WT ...of neurons was reduced in ipsilateral DRGs in both KO and WT ...DRG neurons is partially prevented by Bax deletion, this effect ...
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