Rsv vaccine
Absence of vaccine enhanced RSV disease and changes in pulmonary dendritic cells with adenovirus based RSV vaccine
... approved RSV vac- cine. Screening for a live attenuated RSV vaccine candidate with the right balance of attenuation and immunogenicity has been hampered by a lack of suitable in vitro and in vivo ...
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Attenuated Human Parainfluenza Virus Type 1 (HPIV1) Expressing the Fusion Glycoprotein of Human Respiratory Syncytial Virus (RSV) as a Bivalent HPIV1/RSV Vaccine
... attenuated RSV and HPIV vaccine strains by introducing a series of attenuating muta- tions into the respective viruses using reverse genetics (11, ...express RSV antigens because this strategy has a ...
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Addition of a Missense Mutation Present in the L Gene of Respiratory Syncytial Virus (RSV) cpts530/1030 to RSV Vaccine Candidate cpts248/404 Increases Its Attenuation and Temperature Sensitivity
... A vaccine candidate derived previously from cold-passaged RSV (cpRSV) by two sequential rounds of chemical mutagen- esis and biological ...binant RSV was derived and analyzed to determine the ...
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Cytotoxic T-Lymphocyte Precursor Frequencies in BALB/c Mice after Acute Respiratory Syncytial Virus (RSV) Infection or Immunization with a Formalin-Inactivated RSV Vaccine
... examined RSV-specific CTLp frequencies in BAL samples and spleen cells of BALB/c mice after live- virus infection, compared to FI-RSV ...live- RSV infection, both MHC class I-and II-restricted CTLps ...
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Predicting the relative impacts of maternal and neonatal respiratory syncytial virus (RSV) vaccine target product profiles : a consensus modelling approach
... against RSV infection and disease with respect to the possible vaccine target product profiles (TPPs) and delivery options, and specifically in relation to reduction in early childhood ...of vaccine ...
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In Hot Pursuit of the First Vaccine Against Respiratory Syncytial Virus
... to RSV infection, no clinically approved vaccine is available, and a humanized monoclonal antibody for prophylaxis is not readily affordable in devel- oping ...of RSV vaccines: immune-vulnerable ...
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Host Proteome Correlates of Vaccine-Mediated Enhanced Disease in a Mouse Model of Respiratory Syncytial Virus Infection
... efficacious RSV vaccine has been ...(rVV) RSV-F/RSV-G vaccination-challenge mouse model to study phenotypically distinct vaccine-mediated host immune responses at the proteome ...
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Dissociation between serum neutralizing and glycoprotein antibody responses of infants and children who received inactivated respiratory syncytial virus vaccine
... serum antibody response of infants mud children immuule wlth Formalin-inactlvated respiratory virus RSV vaccine 20 year mgo was deternned by using an enzyme-luiked immunosorbent assay sp[r] ...
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A Respiratory Syncytial Virus Vaccine Vectored by a Stable Chimeric and Replication-Deficient Sendai Virus Protects Mice without Inducing Enhanced Disease
... SeV76 vaccine candidate in ...determined RSV-specific antibody responses in serum samples from immunized ...The vaccine could elicit a high level of RSV-specific antibodies via both ...
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Nonglycosylated G-Protein Vaccine Protects against Homologous and Heterologous Respiratory Syncytial Virus (RSV) Challenge, while Glycosylated G Enhances RSV Lung Pathology and Cytokine Levels
... a vaccine against respiratory syncytial virus (RSV) that will provide protective immunity without the potential for vaccine-associated disease enhancement such as that observed in infants following ...
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Priming with Secreted Glycoprotein G of Respiratory Syncytial Virus (RSV) Augments Interleukin-5 Production and Tissue Eosinophilia after RSV Challenge
... of RSV G to produce cytokines associated with a Th2 response has been clearly demonstrated (2, 4, ...the RSV vaccine- enhanced illness seen in children in FI-RSV vaccine studies in the ...
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A Single-Dose Recombinant Parainfluenza Virus 5-Vectored Vaccine Expressing Respiratory Syncytial Virus (RSV) F or G Protein Protected Cotton Rats and African Green Monkeys from RSV Challenge
... work, RSV F and G were introduced into the intergenic regions of HN and ...the RSV antigen could be further ...placing RSV F in front of HN genes in a PIV5 vector lacking SH may enhance the efficacy ...
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Replacement of the F and G Proteins of Respiratory Syncytial Virus (RSV) Subgroup A with Those of Subgroup B Generates Chimeric Live Attenuated RSV Subgroup B Vaccine Candidates
... attenuated RSV vaccine candidates have been evaluated in animals and humans, and the most promis- ing subgroup A vaccine candidates, based on vaccine candidate cpts248/404 and its recombinant ...
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Development of an Adenovirus-Based Respiratory Syncytial Virus Vaccine: Preclinical Evaluation of Efficacy, Immunogenicity, and Enhanced Disease in a Cotton Rat Model
... a vaccine against respiratory syn- cytial virus (RSV) began 5 decades ...which RSV was inactivated with formalin and administered to RSV-na- ive infants; unfortunately, the product exacerbated ...
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Safety and immunogenicity of novel respiratory syncytial virus (RSV) vaccines based on the RSV viral proteins F, N and M2-1 encoded by simian adenovirus (PanAd3-RSV) and MVA (MVA-RSV); protocol for an open-label, dose-escalation, single-centre, phase 1 clinical trial in healthy adults
... of RSV protein as vaccine ...the RSV proteins F (fusion protein, F0 Δ TM), N (nucleocapsid protein) and M2 – 1 (matrix protein), shown schematically in fi gure ...MVA-RSV vaccine product ...
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Efficacy and Safety Studies of a Recombinant Chimeric Respiratory Syncytial Virus FG Glycoprotein Vaccine in Cotton Rats
... (8). RSV vaccine formulations containing MPL have shown a tendency to shift the immune response toward a Th1 profile in mice (23) and presumably away from a profile associated with enhanced ...
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Adults 65 Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion Protein
... GFP-tagged RSV A2 measured in the elderly donors in our study were consis- tent with previous findings ...(27–30). RSV F- and G-specific IgA antibodies measured in nasal washes of older adults ⱖ 65 years of ...
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Immunoprophylaxis and the Control of RSV Disease
... inactivated RSV vaccine experienced higher mortality and morbidity rates upon subse- quent RSV infection than did infants who received the control ...to RSV glycoprotein ...attenuated ...
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Dual Proinflammatory and Antiviral Properties of Pulmonary Eosinophils in Respiratory Syncytial Virus Vaccine-Enhanced Disease
... acute RSV infection of the lower respiratory tract have an increased likeli- hood of developing childhood asthma ...effective RSV vaccine ...alum-precipitated RSV (FI-RSV) ...
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Enhancing the Thermostability and Immunogenicity of a Respiratory Syncytial Virus (RSV) Live-Attenuated Vaccine by Incorporating Unique RSV Line19F Protein Residues
... an RSV vaccine also remain matters of ...of RSV mortality occurs in infants aged 0 to 3 months, active vaccination of these infants may be problematic due to the immaturity of the immune system, the ...
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