Ruthenium arene anticancer agents
Thiolato-bridged arene ruthenium complexes as anticancer agents
... Properties of Dinuclear Arene Ruthenium Thiolato Complexes We studied cellular mechanisms of action of diruthenium-1 in human MCF-7 and BT-549 breast cancer cells. It exhibited antiproliferative and ...
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Arene Ruthenium(II) Thiosemicarbazone complexes as anticancer agents
... Preparation of Ruthenium Complexes Arene ruthenium complexes were prepared in CDCl 3 and the proton spectra recorded within 30 min of mixing. The reactions had reached completion during this time in ...
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Design, synthesis and activation of ruthenium arene anticancer complexes
... often be enhanced upon coordination with a suitable metal ion; 10 a key concept in the design of metal complexes is the tuning and optimisation of the chemical reactivity to promote possible interactions with the target ...
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Aqueous solution chemistry of ruthenium arene anticancer complexes
... pharmaceutical agents has increased and has lead to a more varied approach to the use of metals in biological and medicinal systems being ...leading anticancer drugs and radiopharmaceuticals containing ...
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Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents
... We also determined the cytotoxicity of 14 selected compounds against the cell lines HEK293, A2780, A24, A2780cisR, and (D-)A24cisPt8.0, which resulted in IC 50 values ranging from 23 to 650 nM. Remarkably, all tested ...
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Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents.
... A ruthenium complex is more cytotoxic than cisplatin on HT-29 cells and it remains active even under hypoxic conditions making it a promising candidate for in vivo ...organometallic ruthenium complexes have ...
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Photoactivatable organometallic pyridyl ruthenium(II) arene complexes
... potential anticancer agents with discriminating preference towards ...II arene pyridine or pyridine-derivative complexes, studies on CT-DNA interactions in cell-free media were carried ...II ...
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Combined arene ruthenium porphyrins as chemotherapeutics and photosensitizers for cancer therapy
... chemotherapeutic agents combining two independent therapeutic modalities with anticancer potential are advantageous for therapeutic efficacy and to overcome resistance ...of ruthenium, as potential ...
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Controlling platinum, ruthenium, and osmium reactivity for anticancer drug design
... V. Concluding Remarks In general transition metal complexes provide enormously versatile platforms for drug design. Many variations in the metal itself, the types and numbers of coordinated ligands and hence in the ...
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The contrasting activity of iodido versus chlorido ruthenium and osmium arene azo and imino pyridine anticancer complexes : control of cell selectivity, cross resistance, p53 dependence, and apoptosis pathway
... mechanisms of resistance with CDDP nor OXA and their activity does not depend on the status of p53 tumor suppressor. Halide switch from chloride to iodide increases the polarization of positive charge on the chelated ...
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Multinuclear ruthenium(II) complexes as anticancer agents
... dinuclear ruthenium( II ) complexes, 27,28,30,40 the cytotoxicity has always increased as the number of methylene groups in the flexible alkane chain ...of anticancer activity is related to DNA binding, ...
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Arene ruthenium chemistry
... 3.3 Structure of arene ruthenium moiety complexes of chapter 2 and 3. From the reaction studies of the[r] ...
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Arene and cyclooctatetraene complexes of ruthenium
... Page 1 Arene-Transition Metal Complexes 5 Bonding in Olefin- and Arene-Metal Complexes 9 Reactions of Arene-Metal Complexes 14 Spectroscopic Properties of Arene-Metal[r] ...
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The Chemistry of arene-olefin complexes of zerovalent ruthenium
... trimethylphosphite but no characterizable products have yet been obtained. These results suggest that a rapid transfer, on the NMR timescal e , of th e hydride prot[r] ...
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Arene ruthenium hydrido complexes and their cyclometallated derivatives
... The general work-up procedure for these compounds was to evaporate the reaction mixture to dryness, extract with toluene and crystallize the hydride by the additi[r] ...
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Organometallic osmium arene anticancer complexes
... Chapter 4: Os II Arene R-azopyridine Complexes A2780 cells were seeded 10 6 cells/well in 6-well plates. After 24 h incubation, cells were exposed to 4 μM osmium complex. After 1 h, 2 h, 4 h and 24 h of drug ...
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Design and development of polynuclear ruthenium and platinum polypyridyl complexes in search of new anticancer agents
... Het antikankermedicijn cisplatina wordt succesvol gebruikt in chemotherapie maar is slechts actief tegen een klein aantal tumoren. Alhoewel de ontwikkeling van analoga wel heeft geresulteerd in een aantal klinisch ...
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Selective arene and polyarene hydrogenation catalysed by ruthenium nanoparticles.
... of Ru and Rh nanoparticles in the hydrogenation of the arene vs. the ketone function. The effect of the nature of the metal, the stabilizing agent and the influence of the substrate structure will be studied. As ...
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Ruthenium complexes as antimicrobial agents
... polypyridyl ruthenium complexes and ruthenium–arene complexes have already been shown to bind and inhibit enzymes such as acetylcholinesterase and protein ...pyridocarbazole ruthenium ...
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Improved catalytic activity of ruthenium–arene complexes in the reduction of NAD+
... Particularly interesting is the effect of the more electron-withdrawing sulphonamide groups from the chelating ligand on weakening the Ru-Cl bond. Longer Ru-Cl distances appear to correlate with an increase in catalytic ...
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