S and G2/M arrest
Cell cycle G2/M arrest through an S phase dependent mechanism by HIV 1 viral protein R
... to S-phase arrest ...from G2 phase to mitosis ...cycle G2 arrest due to the functional redundancy of the Cdc25 phosphatases ...cycle G2/M arrest ...cycle G2 ...
18
The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells
... cycle arrest at G2/M phase [85, 86]. CHK2's role in G2/M arrest is not well ...from G2 into mitosis. CDC2 is kept inactive during G2 phase through ...
20
Bocavirus Infection Induces Mitochondrion-Mediated Apoptosis and Cell Cycle Arrest at G2/M Phase
... cycle arrest at early time points of ...any S-phase accumu- lation in transfection of these mutants other than the infectious clone per se (data not .../M arrest at 48 h posttransfection in ...
12
Synthesis of an anthraquinone derivative (DHAQC) and its effect on induction of G2/M arrest and apoptosis in breast cancer MCF-7 cell line
... MCF-7 at the S and G2/M phases (21.33% ± 1.74% and 37.66% ± 4.11%, respectively) as compared to the control (11.76% ± 1.31% and 4.48% ± %3.72%, respectively) after 48 hours of incubation. DHAQC (2) ...
10
Raltitrexed increases radiation sensitivity of esophageal squamous carcinoma cells
... radiation. G2 and M phases are the critical time points that cells are most sensitive to irradiation and most radioresistant time point was S phase cell ...in G2/M phase tran- sition. ...
12
Tivantinib induces G2/M arrest and apoptosis by disrupting tubulin polymerization in hepatocellular carcinoma
... Microtubule polymerization assays were performed using a fluorescence-based tubulin polymerization assay kit (Cytoskeleton, Denver, CO, USA) according to the manu- facturer’s instructions. Briefly, tubulin was ...
13
Role of garlic derived Allyl sulfide in inducing g2/m checkpoint arrest and apoptosis
... of s from garlic not only has been shown to be a chemotherapeutic compound but also, based on a number of in-vitro, in-vivo and case controlled activity and showing inverse relation with the arlic and incidence of ...
9
Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells
... Notes: (A) DTl depletion increased the proportion of cells in the sub-g1 phases; by contrast, the proportion of human liver cancer cells in the g2/M phase decreased. sk-hep-1 cells were transfected with ...
16
Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma
... The cells were harvested and analyzed with propidium iodide staining to assess cell cycle distribution by FACS analysis and the results were expressed as mean ± SD of three independ- ent experiments. Overlay of cell ...
7
Reovirus-Induced G2/M Cell Cycle Arrest Requires ς1s and Occurs in the Absence of Apoptosis
... Asynchronous, subconfluent monolayers of L929 (A), MDCK (B), C127 (C), HEK293 (D), and HeLa (E) cells were either mock infected (white) or infected with T1L (gray) or T3A (black) at an MOI of 100 PFU per cell. Cells were ...
9
Ethanol Extracts of Coleus tuberosus Flesh and Peel as a Potential Source of Natural Antioxidant and Breast Cancer Prevention Agent
... This study examines the effects of ethanol extracts of Coleus tuberosus flesh and peel on T47D cancer cells. Antioxidant potential was evaluated through cellular antioxidant activity experiment, and anti-proliferation ...
11
Mitochondrial retrograde signaling inhibits the survival during prolong S/G2 arrest in Saccharomyces cerevisiae
... concentrations of the antioxidants (0.1–1 M). The authors favored the possibility that the antioxidants suppressed the elevated ROS production. However, another possibility is that this was because low levels of ...
11
In vitro Anticancer Activity of Pyrazole Fused Triazole Hybrids as Schiff and Mannich Bases through MTT Assay and Flow Cytometry
... cycle arrest probably in the 'G1 ' phase of the cell cycle allowing fewer cells to enter into the S phase, confirming the results obtained in the [3H]-thymidine incorporation ...
5
Vpr Cytopathicity Independent of G2/M Cell Cycle Arrest in Human Immunodeficiency Virus Type 1-Infected CD4+ T Cells
... tant, I70S, as well as the other helix three mutants were pre- dominantly cytoplasmic with most cells exhibiting a staining pattern surrounding the nucleus (Fig. 3A and B). Thus, muta- tions in the exposed hydrophobic ...
13
Original Article Salidroside induces cell cycle arrest and apoptosis in human cervical cancer SiHa cells
... cycle arrest at the G2/M and/or S phases and led to apoptosis in SiHa cells. Our data extend- ed previous findings that salidroside has strong anti-tumor activity against several types of can- ...
9
Cell Cycle Arrest in G2/M Promotes Early Steps of Infection by Human Immunodeficiency Virus
... Quantitative real-time PCR (TaqMan). DNA samples were quantitated by optical density at 260 nm and brought to a concentration of 25 ng/ l before use in quantitative PCR. The primers used to detect late RT products, ...
10
DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1
... to S phase [27], we investigated whether mTOR promotes cell survival following DNA damage by regulating cell cycle arrest, which would consequently allow more time for DNA ...etoposide-induced S and ...
14
Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells
... Clinical evidence suggests that there exists a strong correlation between Zika virus (ZIKV) infection and abnormal development of the nervous system. However, the underlying mechanisms remain to be elusive. In this ...
10
Exposure to reduced oxygenation following radiation exposure enhances the survival of prostate cancer cells in vitro: implications for radiation therapy delivery
... We determined that this survival advantage was associated with induction of a G2/M cell cycle arrest, was not associated with increased DNA repair, was associated with reduced induction [r] ...
176
Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M
... caused G2/M arrest of tubular cells, we examined the expression of Numb, p-H3 and TGF-β1 in human renal fibrosis biopsies by immunohistochemical staining in sequential sections of renal biopsies from ...
16