S. mansoni
A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S mansoni infection
... Compared to untreated control and equivalent doses of M-PZQ, SLN-PZQ at doses of 250, 500 and 1000 mg/ kg interrupted worm oviposition capacity, which was reflected as a significant reduction in both the hepatic and ...
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Relative compatibility of Schistosoma mansoni with Biomphalaria sudanica and B pfeifferi from Kenya as assessed by PCR amplification of the S mansoni ND5 gene in conjunction with traditional methods
... that S. mansoni of Kenyan origin is highly compatible with Kenyan ...several S. mansoni isolates from both Africa and the Americas tested against both African and American Biomphalaria species ...
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Assessing S mansoni prevalence in Biomphalaria snails in the Gombe ecosystem of western Tanzania: the importance of DNA sequence data for clarifying species identification
... Most sequenced snail samples were B. pfeifferi but some belonged to a sister clade resolved in recent phylogenetic analyses [4, 36]. All of the species in this clade are thought to be susceptible to S. ...
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Modelling age heterogeneous Schistosoma haematobium and S mansoni survey data via alignment factors
... of S. mansoni prevalence occurs somewhat later, up to the age of 20 years ...to S. mansoni. Additionally, the peak of S. mansoni prevalence might be further shifted towards older ...
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Prevalence Of Single And Dual S. Mansoni And S. Haematobium Infections In Primary School Going Children, An Indicator Of Infection Status In The Community After Two Years Of Deworming In Taveta Sub County, Kenya
... study conducted by [6] in three villages in Taveta, reveals a parallel situation to this current study: that children display the highest rate of infection with schistosomiasis. The study further revealed that egg ...
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Serodiagnosis of Imported Schistosomiasis by a Combination of a Commercial Indirect Hemagglutination Test with Schistosoma mansoni Adult Worm Antigens and an Enzyme Linked Immunosorbent Assay with S mansoni Egg Antigens
... Patients and sera. Patients incorporated into this study attended The Aca- demic Medical Centre, Amsterdam, The Netherlands; The Harbor Hospital and Institute of Tropical Diseases, Rotterdam, The Netherlands; and The ...
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Identification of G protein coupled receptors in Schistosoma haematobium and S mansoni by comparative genomics
... of S. haematobium and S. mansoni are conserved, except for members of the SmGPR clade, which appear to have diverged in these ...each S. haematobium and S. mansoni, further study ...
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Decline in transmission of schistosomiasis mansoni in Oman
... of S. mansoni infection in areas at risk in Dhofar reflect the different phases experienced by Oman in its fight against schistosomiasis: the gradual reduction of risk of acquiring new infections in the ...
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Drugs for treating Schistosoma mansoni infection
... For praziquantel, the evidence presented is generally supportive of the current WHO recommended dose of 40 mg/kg to treat S. mansoni infection (WHO 2002). Parasitological cure as low as 57% has been ...
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Expression of a 28-Kilodalton Glutathione S-Transferase Antigen of Schistosoma mansoni on the Surface of Filamentous Phages and Evaluation of Its Vaccine Potential
... A cloning and expression system that allows display of proteins on the surface of filamentous phages was exploited to display a 28-kDa glutathione S-transferase (Sm28GST) antigen of the human parasite Schistosoma ...
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The Schistosoma mansoni lipidome: Leads for immunomodulation
... eggs. S. mansoni infections are often chronic in nature, which in part is thought to be due to the ability of these parasites to promote regulatory responses that can dampen anti-parasitic type 2 in fl ...
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The investigation of protective concomitant immunity in murine schistosomiasis mansoni
... The egg count of S. mansoni in the perfused liver of mice was estimated after alkali digestion as previously described [21] with modifications. Briefly, at the time of perfusion, whole livers of ...
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Isothermal Microcalorimetry To Study Drugs against Schistosoma mansoni
... adult S. mansoni worms to 10 g/ml mefloquine and after 21 h following exposure to 100 g/ml ...50 s can be exactly determined by analyzing parasite motility (amplitudes in thermogenic curves), ...
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Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug
... of S. mansoni isolates from Puerto Rico, Brazil, Kenya and Egypt that had been maintained in the laboratory for up to 10 years to increasing sub-curative doses of ...with S. mansoni (LE ...
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GPCR and IR genes in Schistosoma mansoni miracidia
... Livers were obtained from ARC Swiss mice infected with S. mansoni (Puerto Rican strain), under conditions speci- fied by the Australian Department of Agriculture, Fisher- ies and Forestry (DAFF). A 2-day ...
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Role of Host Granulomatous Response in Murine Schistosomiasis Mansoni: EOSINOPHIL MEDIATED DESTRUCTION OF EGGS
... Schistosoma mansoni eggs, but their functional role in these granulomas and their relation to egg destruction is ...of S. mansoni infection in mice treated with normal rabbit serum (NRS) or depleted ...
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Inferences on the biochemical and environmental regulation of universal stress proteins from Schistosomiasis parasites
... We have determined protein sequence length, protein domain length, ligand-binding sites, biologically relevant chemical ligands, enzymatic regulation, developmental regulation, and subcellular localization for 13 ...
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Comparative histochemical study of four enzyme activities on some organs of male Schistosoma mansoni and S. haematobium
... In the present study, the activity of these enzymes in the oral sucker, ventral sucker, intestine, oesophagus, muscles, gynaecophoral canal edge, tubercles, tegument folds and excretory pore of two species indicated that ...
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Infection against infection: parasite antagonism against parasites, viruses and bacteria
... Parasites were also found to reduce the severity of viral in- fections. Giardia lamblia might modulate the pathogen- icity of rotaviruses if concurrent infections occur [62]. Compared with rotavirus monoinfections, G. ...
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Simultaneous infection of Schistosoma mansoni and S rodhaini in Biomphalaria glabrata: impact on chronobiology and cercarial behaviour
... S. mansoni and ...lateral-spined S. mansoni group ...host. S. mansoni can infect both primates and rodents [10] and ...for S. mansoni and rodents for ...Indeed, ...
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