S phase cell-cycle arrest
High temperature suppressed SSC self-renewal through S phase cell cycle arrest but not apoptosis
... GFRα-1 and PLZF during in vitro culture (Fig. 1b). To explore the effects of heat stress on SSCs, we treated them at 43 °C for 10 min, 15 min, 30 min, 45 min and 60 min. We found that the heat shock treatment at 43 °C ...
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Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway
... an S phase cell cycle arrest in proliferating ...of cell death in the mutants with defects in replication stress response, the mechanism underlying the cytotoxicity of HU in ...
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Chloroformic fraction of Tanacetum vulgare L. induces cell cycle arrest and apoptosis in MCF7 cells
... (MCF7) cell lines through MTT ...stronger cell growth inhibitory effect than the aqueous methanolic fraction toward the three cancer cell ...causes cell cycle arrest at the ...
5
Dale Bates Senior Honors Thesis.pdf
... Cell cycle analysis of wild type cells treated with SHH and/or CHIR-98014 through FACS revealed that cells treated with CHIR-98014 shift away from S ...in S phase and G2-M phase ...
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Original Article S-1 and celecoxib synergistically suppress pancreatic cancer growth by promoting apoptosis in vivo and in vitro
... the cell cycle regulator CDK4, thus accelerating the cell cycle G 1 /S conversion pro- cess, thus indirectly inhibiting the activity of caspase-3 by the release of P21 and prevent- ing ...
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Mouse 24p3 Protein Has an Effect on L929 Cell Viability
... inducing cell death may lead to S-phase arrest in L929 cells resulting in DNA ...delayed cell cycle progression and triggered cell ...this, cell cycle ...
8
Biological Activity of N Hydroxyethyl 4 aza 2,3 didehydropodophyllotoxin Derivatives upon Colorectal Adenocarcinoma Cells
... the S phase to permit reparation of any DNA ...regulate cell cycle progression [28] ...which cell cycle arrest with DNA fragmentation have been documented [30] in this ...
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Influence of Carbon Monoxide on Growth and Apoptosis of Human Umbilical Artery Smooth Muscle Cells and Vein Endothelial Cells
... muscle cell (hUASMC) and human umbilical vein endothelial cell (HuVEC) and further evaluated the growth and apoptosis status of SMC and ...blocked cell cycle progress of SMC and HuVEC, more ...
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Cell cycle G2/M arrest through an S phase dependent mechanism by HIV 1 viral protein R
... different cell types (HeLa and CEM-SS), which suggest a general effect of Vpr on these ...show cell cycle-specific effect; while when asynchronized CEM-SS cells were used Vpr may have lit- tle or no ...
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Original Article Salidroside induces cell cycle arrest and apoptosis in human cervical cancer SiHa cells
... viability, cell cycling and apoptosis of cervical cancer SiHa cells and its potential ...Methods: Cell growth potential was measured by Cell Counting Kit-8 assay and colony ...formation. Cell ...
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ROSMARINIC ACID ENHANCES CISPLATIN CYTOTOXICITY IN HEPG2 CELL LINE AND ATTENUATES ITS NEPHROTOXICITY IN MICE
... Consequently, it is of great importance to explore ways for the alleviation of the dose-limiting adverse effects of cis at its tumoricidal doses for safer clinical application. Evidence from earlier studies has ...
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The role of p21 in regulating mammalian regeneration
... markers, cell cycle re- entry, proliferation, formation of a blastema, and diff er- en tiation into adult tissue ...in cell cycle re- entry through phosphorylation by CDK4/6 ...into ...
7
<p>Nudol, a phenanthrene derivative from <em>Dendrobium nobile</em>, induces cell cycle arrest and apoptosis and inhibits migration in osteosarcoma cells</p>
... Moreover, we found that the migration of U2OS cells was greatly inhibited by treatment of nudol(1). It is well known that cancer invasion and metastasis are a complicated multi- step process involving numerous effects or ...
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ANTICANCER EFFECT OF NEMATOCYSTS VENOM FROM JELLYFISH ACROMITUS FLAGELLATUS, ON HUMAN BREAST CANCER CELL LINE
... apoptotic cell indicate the activation of proteolytic enzymes which eventually mediate the cleavage of ...of cell death after cytotoxic drug treatment [39] ...in cell-cycle regulation [41] ...
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MERTK as a novel therapeutic target in head and neck cancer
... on cell migration and invasion in HNSCC and that this effect is primarily mediated by RhoA ...with cell motility has previously been shown in melanoma, glioblastoma and non-tumorigenic breast epithelial ...
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Effect of TLR2 on the proliferation of inflammation-related colorectal cancer and sporadic colorectal cancer
... Methods: Twelve C57BL/6 J wild-type mice (WT) and 12 TLR2 knockout mice (TLR2-/-) were used to rapidly establish a colitis-associated cancer (CAC) model via the 1,2-dimethylhydrazine-dextran sodium sulfate (DMH-DSS) ...
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Suppression of STIM1 inhibits human glioblastoma cell proliferation and induces G0/G1 phase arrest
... growth arrest in human G401 rhabdoid tumor cells and human RD rhabdomyosarcoma cells ...on cell proliferation and cell cycle progression in U251 ...G1 phase progression through ...
9
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction
... We used CCK8 assay to identify influences of quisinostat on proliferation in five human HCC cell lines (HCCLM3, SK-hep-1, Hep-3B, Huh7 and SMMC-7721) respectively (Fig. 2A). It was observed that quisinostat ...
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High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway
... To validate whether FOXO3 is a crucial functional down- stream of RAP1A, we constructed the specific plasmid to overexpress FOXO3 expression in CRC cells. The qRT-PCR and western blot indicated FOXO3 expression was ...
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Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin
... between cell cycle regulation and cancer, and inhibition of the cell cycle has become an appreciated target for cancer management ...G2/M phase arrest in MDA-MB-231 ...a ...
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