sarco(endo)plasmic reticulum
Temperature perturbation studies of sarcoplasmic reticulum from malignant hyperthermia pig muscle
... susceptible group (MHX). At 25 degrees C, calcium binding was lower for MHS than for controls and MHX. As temperature was increased by 2 degrees C jumps, calcium binding decreased in all sarcoplasmic ...
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Phospholamban mediated stimulation of Ca2+ uptake in sarcoplasmic reticulum from normal and failing hearts
... pathophysiology of heart disease. A monoclonal antibody that binds to phospholamban and stimulates Ca2+ uptake was used to characterize phospholamban-mediated effects in human cardiac sarcoplasmic reticulum ...
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Sarcolemmal ion currents and sarcoplasmic reticulum Ca2+ content in ventricular myocytes from the cold stenothermic fish, the burbot (Lota lota)
... 2002). Although some ectotherms cope with cold temperatures via cold-torpor and resultant reductions in metabolic rate and heart rate, there are several compensative changes often associated with ectotherms that remain ...
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Calcium transport by skeletal muscle sarcoplasmic reticulum in the hypothyroid rat
... by sarcoplasmic reticulum has reached maximum levels, results in a depression in the rate of calcium ...the sarcoplasmic reticulum to account for the low calcium transport in ...by ...
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Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum
... Fully differentiated skeletal muscle fibers are multinucleated, elongated cells with highly ordered cytoplasm, essential for efficient muscle contraction and organismal movement. Muscle nuclei are positioned evenly along ...
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Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation
... the sarcoplasmic reticulum (SERCA2) plays a dominant role in lowering cytoplasmic calcium levels during cardiac relaxation and reduction of its activity has been linked to delayed diastolic relaxation in ...
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High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with acidic stores (lysosomes) in the heart
... Conventional TEM methods utilising higher concentrations of glutaraldehyde and followed by Spurr resin embedding allow for better visualisation of membranes. Whilst this method is ideal for imaging intra- cellular ...
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Molecular cloning and characterization of a Ca2+ + Mg2+ dependent adenosine triphosphatase from rat cardiac sarcoplasmic reticulum Regulation of its expression by pressure overload and developmental stage
... To investigate the regulation of expression of cardiac Ca2+ + Mg2+-dependent ATPase (Ca2+-ATPase) in sarcoplasmic reticulum (SR), we isolated cDNA (pHA6) encoding a Ca2+-ATPase of rat cardiac SR. The clone ...
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The effect of chlorpyrifos upon ATPase activity of sarcoplasmic reticulum and biomechanics of skeletal muscle contraction
... of sarcoplasmic reticulum (SR) and biomechanical contractile properties of skeletal muscle (SM), and to analyze the progression of these changes over time depending on concentrations of the ...
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3D ultrastructural organisation of calcium release units in the avian sarcoplasmic reticulum
... in avian left atrial tissue. (A) 2D image from a reconstructed tomogram stack, with a segmented model overlaid. The segmented model shows: peripheral couplings (PCs; purple) and the nearest edge – edge distances between ...
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Comparative studies on the sarcoplasmic reticulum of fish muscle
... Huxley, 1957, 1964; Andersen-Cedergren, 1958; Peachy, 1965)* Essentially, the SR is a fine reticular structure of membrane limited elements (Franzini-Armstrong, 1973). There are many similarities between the ...
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The role of the sarcoplasmic reticulum in the generation of high heart rates and blood pressures in reptiles
... reticulum (SR) in the generation of high heart rates and blood pressures was investigated in four species of reptile; the turtle, Trachemys scripta; the python, Python regius, the tegu lizard, Tupinanvis merianae, ...
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Temperature dependence of cardiac sarcoplasmic reticulum function in rainbow trout myocytes
... Furthermore, we the effect of varying stimulation pulse number, frequency observed SR-Ca2+-dependent inactivation of the L-type and experimental temperature 7°C, 14°C and 21°C on Ca2+ ch[r] ...
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Effect of Dietary Nitrate on Force Production and Sarcoplasmic Reticulum Ca2+ Handling in Rat Fast Twitch Muscles Following Eccentric Contraction
... Impaired excitation-contraction coupling occurs in eccentric contraction (ECC)-induced damaged muscles. It has been suggested that sarcoplasmic re- ticulum (SR) is susceptible to damage in the overstretched ...
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Sarcoplasmic Reticulum Ca release in Intact Ventricular Myocytes
... Combining molecular biology techniques with Ca2+ imaging methods represents an almost ideal approach for engineering less complex experimental models. After the skeletal and cardiac muscle isoforms of the RyR (i.e. RyR1 ...
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Ca++ Uptake and ATPase of Human Sarcoplasmic Reticulum
... ATPase activity of grana obtained from human white muscle was only slightly inhibited by sodium azide; purified grana activity showed little or no inhibition by azide Table III.. The ATP[r] ...
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Catalytic activity and heat production by the Ca(2+) ATPase from sea cucumber (Ludwigothurea grisea) longitudinal smooth muscle: modulation by monovalent cations
... Hill, B., Sanger, J. W. and Chen, C. (1982). Close apposition of muscle cells in the longitudinal bands of the body wall of a holothurian, Isostichopus badionotus. Cell Tissue Res. 227, 465–473. Hill, R. B., Sanger, J. ...
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Adaptive thermogenesis in hummingbirds
... Although birds are the sarcoplasmic reticulum Ca2+-ATPase, uncoupled from endothermic vertebrates, sharing with mammals placental ATP synthesis, is one mechanism whereby chemi-osmotic ma[r] ...
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GENETICS AND MOLECULAR BIOLOGY AND PIG MEAT QUALITY IMPROVEMENT
... 16.Otsu, K., Nishida, K., Kimura, Y., Kuzuya, T., Hori, M., Kamada, T., Tada, M. (1994) – The point mutation arg615-to-cys in the Ca(2+) release channel of skeletal sarcoplasmic reticulum is responsible for ...
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Investigation of the mechanisms of Angelica dahurica root extract induced vasorelaxation in isolated rat aortic rings
... Effects of ADE on intracellular Ca2+ release: In order to investigate the effects of ADE on intracellular Ca2+ release from sarcoplasmic reticulum SR-induced contraction via specific ino[r] ...
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