Sarcoma-associated herpesvirus
Computational Investigation of Marine Bioactive Compounds Reveals Frigocyclinone as a Potent Inhibitor of Kaposi’s Sarcoma Associated Herpesvirus (KSHV) Targets
... Bioactive compound structural identification The present study mainly focuses to predict bioactive compounds against Kaposi’s sarcoma associated herpesvirus disease (Table 1). The chemical structure ...
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RNAs in the Virion of Kaposi's Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV) typically results in a latent ...other herpesvirus virions, we sought to determine if KSHV virions contained RNAs and, if so, whether these RNAs ...
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Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Upregulates Survivin Expression in KSHV-Associated B-Lymphoma Cells and Contributes to Their Proliferation
... Kaposi’s sarcoma-associated herpesvirus (KSHV) that is found in Kaposi’s sarcoma tumors, upregulates survivin expression and increases the proliferation of KSHV-infected B ...Kaposi’s ...
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A Cluster of Latently Expressed Genes in Kaposi’s Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is closely associated with Kaposi’s sarcoma (KS) and primary effusion lymphoma, with viral genomes present in a latent state in the ...
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Investigation of the Multimerization Region of the Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Protein K-bZIP: the Proposed Leucine Zipper Region Encodes a Multimerization Domain with an Unusual Structure
... Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) shares many functional similarities with the BZLF1 gene of Epstein-Barr ...
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Lipid Rafts of Primary Endothelial Cells Are Essential for Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8-Induced Phosphatidylinositol 3-Kinase and RhoA-GTPases Critical for Microtubule Dynamics and Nuclear Delivery of Viral DNA but Dispensable for Binding and Entry
... Kaposi’s sarcoma-associated herpesvirus (KSHV) (human herpesvirus 8 [HHV-8]) induces the host cell’s preexisting FAK, Src, phosphatidylinositol 3-kinase (PI3-K), Rho-GTPases, Diaphanous-2 ...
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Downregulation of Gamma Interferon Receptor 1 by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5
... Kaposi’s sarcoma-associated herpesvirus (KSHV) has devel- oped a unique mechanism for antagonizing cellular IFN-me- diated antiviral activity by incorporating viral homologs of sev- eral cellular ...
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Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus
... ABSTRACT The regulation of latency is central to herpesvirus biology. Recent transcriptome-wide surveys have uncovered evidence for promiscuous transcription across the entirety of the Kaposi’s ...
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Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Replication and Transcription Activator Regulates Viral and Cellular Genes via Interferon-Stimulated Response Elements
... Kaposi’s sarcoma-associated herpesvirus (also called human herpesvirus 8 [HHV-8]) replication and tran- scription activator (RTA) is apparently necessary and sufficient for the switch from ...
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The latency associated nuclear antigen of Kaposi sarcoma–associated herpesvirus induces B cell hyperplasia and lymphoma
... Kaposi sarcoma–associated herpesvirus (KSHV) is a human lymphotropic herpesvirus. It is implicated in B cell neoplasias such as primary effusion lymphoma and multicentric Castleman disease in ...
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Virion Proteins of Kaposi's Sarcoma-Associated Herpesvirus
... a herpesvirus virion are thought to contain the functional information required for de novo infection, as well as virion assembly and ...Kaposi’s sarcoma-associated herpesvirus (KSHV) virion ...
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Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is found in Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and tumors from patients with the plasmablastic variant of multicentric ...
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Complex Alternative Cytoplasmic Protein Isoforms of the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Generated through Noncanonical Translation Initiation
... Complex Alternative Cytoplasmic Protein Isoforms of the Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen 1 Generated through Noncanonical Translation Initiation[r] ...
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Kaposi's Sarcoma-Associated Herpesvirus Reactivation Is Regulated by Interaction of Latency-Associated Nuclear Antigen with Recombination Signal Sequence-Binding Protein Jκ, the Major Downstream Effector of the Notch Signaling Pathway
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major biological cofactor contributing to develop- ment of Kaposi’s ...latency- associated nuclear antigen (LANA), a critical factor in ...
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Chromosome Binding Site of Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Is Essential for Persistent Episome Maintenance and Is Functionally Replaced by Histone H1
... Kaposi’s sarcoma-associated herpesvirus (KSHV; human herpesvirus 8) persistently maintains a plasmid containing the KSHV latent origin of replication (oriP) as a closed circular episome in ...
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Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma.
... Kaposi’s sarcoma (KS) has an infectious etiology (5), and this led to the identi- fication of sequences of a new gammaherpesvirus in KS tumor tissue (9), termed Kaposi’s sarcoma-associated ...
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Differential Expression of Viral Bcl-2 Encoded by Kaposi's Sarcoma-Associated Herpesvirus and Human Bcl-2 in Primary Effusion Lymphoma Cells and Kaposi's Sarcoma Lesions
... Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or ...Kaposi’s sarcoma-associated herpesvirus latent and lytic gene ...
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Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma.
... human herpesvirus was recently identified in all forms of Kaposi’s sarcoma (Kaposi’s sarcoma- associated herpesvirus [KSHV] or human herpesvirus 8), as well as in primary ...
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Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Replication and Transcription Factor Activates the K9 (vIRF) Gene through Two Distinct cis Elements by a Non-DNA-Binding Mechanism
... Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, a homologue of Epstein-Barr virus BRLF1 or Rta, is a strong transactivator and inducer of lytic ...
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Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
... Kaposi’s sarcoma-associated herpesvirus (KSHV) DNA persists in latently infected cells as an episome via tethering to the host ...predominantly associated with the chromatin structure at the ...
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