scavenger receptor B type I
Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I
... (61), scavenger receptor B type I (SR-BI) (68), which is a cellular protein that binds high-density lipoprotein (HDL), the low-density lipoprotein receptor (LDL-R) (1, 52), the ...
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Different Requirements for Scavenger Receptor Class B Type I in Hepatitis C Virus Cell-Free versus Cell-to-Cell Transmission
... SR-BI’s involvement in both primary attachment and entry of extracellular virions (cell-free entry route) and spread (cell-to-cell transmission route) suggests that antibodies or small molecules targeting SR-BI might be ...
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Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
... Previous studies have shown that Akt can inhibit apoptosis through a variety of mechanisms, including the phosphorylation of BAD, thus preventing cytochrome c release from mitochondria and the direct inhibition of the ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... Overexpression of SR-BI in the liver, while reducing levels of HDL-C in plasma, is known to reduce atherosclerosis in mice (8–10). This suggested that hepatic SR-BI overexpression may pro- mote RCT, but this concept had ...
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Original Article Relationship between SR-BI genetic polymorphism and coronary heart disease and blood lipid level
... Scavenger receptor class B type I (SR-BI) is a high density lipoprotein receptor that can selec- tively mediate cholesteryl ester absorption [1, ...
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Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages
... B, the activation of the mitogen-activated protein kinase p38, and the secretion of IFN- ␣ /  and IL-6 at various time points after Ad ... B subunit p65 was used to analyze NF- B ... B ...
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A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I
... While natural hepatitis C virus (HCV) infection results in highly diverse quasispecies of related viruses over time, mutations accumulate more slowly in tissue culture, in part because of the inefficiency of replication ...
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Hyperglycemia promotes overexpression of SR BII isoform of the scavenger receptor class B type I in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina
... Type 2 diabetes mellitus (T2DM) has emerged as one of the most prevalent chronic diseases worldwide. De- creased plasma high-density lipoprotein cholesterol (HDL- c) is one of the most common lipid disorders in ...
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Hepatic overexpression of bovine scavenger receptor type I in transgenic mice prevents diet induced hyperbetalipoproteinemia
... suppressed in TgSR+/- and TgSR+/+ mice. The rise in HDL was similar in control and TgSR+/- mice, but significantly elevated in the TgSR+/+ mice. Overall, on chow, the ratio of apo-B containing lipoprotein ...
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Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke
... both type I and type II diabetes lead to risk factors that contribute to stroke, as type I diabetics are more prone to hypertension, coronary heart disease, peripheral ar- terial ...
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Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus
... In summary, HVR1 deletion and HVR1 deletion adaptive en- velope mutations did not affect the amount and trafficking of Core in the H77 viral life cycle from replication to release, whereas they had a significant impact ...
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Human scavenger receptor class B, type II (SR-BII) and cellular cholesterol efflux
... finding, I proceeded to determine whether there is a stronger interaction between cytoplasmic SR-BII and the SH3 domain o f plc-yl when either its two adjacent SH2 signalling domains are present, or the plc-yl SH3 ...
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The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection
... The precise mechanisms regulating hepatitis C virus (HCV) entry into hepatic cells remain unknown. However, several cell surface proteins have been identified as entry factors for this virus. Of these molecules, ...
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High-Avidity Monoclonal Antibodies against the Human Scavenger Class B Type I Receptor Efficiently Block Hepatitis C Virus Infection in the Presence of High-Density Lipoprotein
... It was recently shown that HCVpp entry is facilitated by human serum or HDL in an SR-B1-dependent manner (6, 28, 44). In addition, drugs inhibiting the HDL cholesterol transfer mediated by SR-B1 abolished HDL-mediated ...
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Expression of the Scavenger Receptor Class B type I (SR BI) family in Drosophila melanogaster
... the fat body, the midgut and the Malpighian tubules, and reveals its expression in the garland cells. In addition, we also show that the expression of ninaD in the midgut is temporally regulated (Fig. 5G-I). This ...
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Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice
... SR-BI: scavenger receptor class B type I; TC: total cholesterol; TNF-α: tumor necrosis factor α; 2DE: 2D nondenaturing agarose-polyacrylamide gel ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... Initially, scavenger receptor activity was identified as “AcLDL receptor activity” by Brown, Gold- stein, and colleagues (2), who were developing an in vitro model for the deposition of LDL ...
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Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
... The role of SR-BI in cholesterol transport and steroidogen- esis in humans remains to be established. Selective uptake of HDL-cholesteryl esters has been demonstrated in primary cul- ture of human hepatocytes (60) but ...
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Scavenger Receptor Class B Type I and Hepatitis C Virus Infection of Primary Tupaia Hepatocytes
... FIG. 7. (A) Sensitivity and specificity of HCV RNA detection from hepatocytes by strand-specific RT-PCR. Different amounts of in vitro- synthesized positive- or negative-strand HCV RNAs (synthesized as described in ...
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Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants
... lipoprotein receptor of 509 amino acids (aa) with cytoplasmic C- and N-terminal domains separated by a large extracellular domain (1, 13, ...endocytic receptor (45, 46, 51, ...putative receptor for ...
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