scavenger receptor class B type I
Hyperglycemia promotes overexpression of SR BII isoform of the scavenger receptor class B type I in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina
... The scavenger receptor class B type I (SR-BI) is a high-density lipoprotein (HDL) receptor in- volved in reverse cholesterol ...that type 2 diabetes status is char- ...
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Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice
... SR-BI: scavenger receptor class B type I; TC: total cholesterol; TNF-α: tumor necrosis factor α; 2DE: 2D nondenaturing agarose-polyacrylamide gel ...
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Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
... The scavenger receptor, class B, type I (SR-BI) binds HDL and mediates the selective transfer of cholesteryl esters from HDL to cultured ...this receptor may deliver ...
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Role of Scavenger Receptor Class B Type I in Hepatitis C Virus Entry: Kinetics and Molecular Determinants
... Scavenger receptor class B type I (SR-BI) is an essential receptor for hepatitis C virus (HCV) and a cell surface high-density-lipoprotein (HDL) ...for receptor ...
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Scavenger Receptor Class B Type I and Hepatitis C Virus Infection of Primary Tupaia Hepatocytes
... Human scavenger receptor class B type I (SR-BI) represents an HCV receptor candidate mediating the cellular binding of E2 glycoprotein to HepG2 hepatoma ...
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A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I
... While natural hepatitis C virus (HCV) infection results in highly diverse quasispecies of related viruses over time, mutations accumulate more slowly in tissue culture, in part because of the inefficiency of replication ...
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Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
... HDL receptor, the scavenger receptor class B, type I (SR-BI), and subsequent lipid transfer to the cell ...HDL receptor and has been shown to mediate the selective ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... Plasma levels of HDL cholesterol (HDL-C) and its major protein apoA-I are inversely associated with the risk of atherosclerotic vas- cular disease. One mechanism by which HDL and apoA-I protect against ...
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Different Requirements for Scavenger Receptor Class B Type I in Hepatitis C Virus Cell-Free versus Cell-to-Cell Transmission
... Hepatitis C virus (HCV) is believed to initially infect the liver through the basolateral side of hepatocytes, where it engages at- tachment factors and the coreceptors CD81 and scavenger receptor ...
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Hypervariable Region 1 Deletion and Required Adaptive Envelope Mutations Confer Decreased Dependency on Scavenger Receptor Class B Type I and Low-Density Lipoprotein Receptor for Hepatitis C Virus
... Deletion of HVR1 and HVR1-related adaptive envelope mu- tations decreased HCV dependency on LDLr and SR-BI, respec- tively. Previous reports had indicated a relationship between HVR1 and the lipoprotein receptor ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... multiligand scavenger receptor that binds anionic phospholipids and modi- fied proteins to be involved in pattern recognition for host defense and/or removal of senescent/apoptotic cells (1, ...one ...
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Expression of the Scavenger Receptor Class B type I (SR BI) family in Drosophila melanogaster
... In the scope of our study, where we focused our attention on three developmental times in a variety of larval tissues, we could observe highly dynamic and, in some cases, restrictive patterns of expression. Some genes ...
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Original Article Relationship between SR-BI genetic polymorphism and coronary heart disease and blood lipid level
... of scavenger receptor class B type I (SR-BI) exon 1 and intron 5 on blood lipid level and susceptibility to coronary heart disease (CHD) of Chinese Han popula- tion in ...
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The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection
... The precise mechanisms regulating hepatitis C virus (HCV) entry into hepatic cells remain unknown. However, several cell surface proteins have been identified as entry factors for this virus. Of these molecules, ...
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High-Avidity Monoclonal Antibodies against the Human Scavenger Class B Type I Receptor Efficiently Block Hepatitis C Virus Infection in the Presence of High-Density Lipoprotein
... We previously showed that polyclonal antibodies generated by DNA immunization of mice recognizing the SR-B1 ectodo- main were capable of inhibiting sE2 binding to Huh-7 and HepG2 human hepatoma cells (5). In line with ...
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Human scavenger receptor class B, type II (SR-BII) and cellular cholesterol efflux
... this receptor to be linked to a particular function in future cholesterol efflux and mobilisation ...homeostasis, I wanted to match one o f the CHO-SR-BII clones with a CHO-SR-BI clone expressing similar ...
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Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke
... both type I and type II diabetes lead to risk factors that contribute to stroke, as type I diabetics are more prone to hypertension, coronary heart disease, peripheral ar- terial ...
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Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice
... ator–activated receptor-γ (PPAR-γ) ligands (30, 31). Unlike SRA I/II, CD36 is more broadly expressed (32–35) and has been shown to play a strategic role in lipoprotein and lipid metabolism (36, ...
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Initiation of Hepatitis C Virus Infection Is Dependent on Cholesterol and Cooperativity between CD81 and Scavenger Receptor B Type I
... M  CD depletion of cholesterol from Huh-7 cells inhibits HCV infection. Since cholesterol depletion by M  CD led to a decrease in cell surface expression levels of CD81, we deter- mined whether cellular cholesterol ...
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Oxidized or acetylated low density lipoproteins are rapidly cleared by the liver in mice with disruption of the scavenger receptor class A type I/II gene
... FcgIIB receptor (20), CD36 (21), SR-BI (22), and macrosialin, or its human homologue, CD68 ...LDL receptor has been highlighted by the demonstration that macrophages from CD36-deficient human subjects ...
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