scavenger receptor type BI
Human scavenger receptor class B, type II (SR-BII) and cellular cholesterol efflux
... LDL receptor expression and increase LDL clearance from the bloodstream ...the scavenger receptor class B, type I (SR-BI), and the ATP-binding cassette transporter, class A1 (A B C A l) ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... One important limitation of these studies in extrapolating the results to human physiology is that mice, in contrast to humans, lack the CE transfer protein (CETP). CETP transfers CEs from HDL to apoB-containing ...
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Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
... Prior studies have implicated the rat adrenal gland as a ma- jor site of HDL receptor activity (8, 9, 13–17, 32–34). Com- pared to the rabbit and hamster, the rat produces extremely large amounts of adrenal ...
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Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier
... Scavenger receptor class B type I (SR-BI) mediates the selective uptake of cholesteryl esters (CE) from high- density lipoproteins (HDL). An impaired SR-BI function leads to ...
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Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver
... Scavenger receptor class B, type I (SRBI) is a key regulator of high density lipoprotein (HDL) ...lipoprotein receptor, and cholesterol 7 ␣ -hydrox- ...
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Cholesterol binding, efflux, and a PDZ interacting domain of scavenger receptor–BI mediate HDL initiated signaling
... B scavenger receptor family, ...B scavenger receptors to either the plasma membrane or lysosomal membrane and assessed cholesterol bind- ing (Figure ...B scavenger receptor family ...
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Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... multiligand scavenger receptor that binds anionic phospholipids and modi- fied proteins to be involved in pattern recognition for host defense and/or removal of senescent/apoptotic cells (1, ...one ...
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Original Article Relationship between SR-BI genetic polymorphism and coronary heart disease and blood lipid level
... of scavenger receptor class B type I (SR-BI) exon 1 and intron 5 on blood lipid level and susceptibility to coronary heart disease (CHD) of Chinese Han popula- tion in ...
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In vivo regulation of scavenger receptor BI and the selective uptake of HDL cholesteryl esters in rat liver parenchymal and Kupffer cells
... SR-BI was found to bind a broad spectrum of ligands, includ- ing modified lipoproteins, native lipoproteins, and also anionic phospholipids (16). Recently, the HDL binding to SR-BI was shown to be mediated ...
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Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice
... SR-BI: scavenger receptor class B type I; TC: total cholesterol; TNF-α: tumor necrosis factor α; 2DE: 2D nondenaturing agarose-polyacrylamide gel ...
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Scavenger receptor BI plays a role in facilitating chylomicron metabolism
... introduce scavenger receptor class B type I (SR-BI) as a new player in postprandial lipid ...for scavenger class A receptors. In addition to CE, SR-BI selec- tively takes up a ...
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An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI
... HDL mimetic peptides with 18-22 amino acids are designed to mimic apoA-I's ability to form class A amphipathic helices without sharing sequence simi- larity to apoA-I protein. On one hand, their sequence diversity offers ...
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Expression of the Scavenger Receptor Class B type I (SR BI) family in Drosophila melanogaster
... In the scope of our study, where we focused our attention on three developmental times in a variety of larval tissues, we could observe highly dynamic and, in some cases, restrictive patterns of expression. Some genes ...
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Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes
... In the present study, we found lack of SR-BI caused TC and HDL-C accumulation, which was consistent with previous studies [11]. As s constituent of HDL, serum ApoM level also increased in SR-BI deficient ...
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LRP: a multifunctional scavenger and signaling receptor
... LDL receptor gene family, consists of five common structural units shown in Fig- ure 1: (a) ligand-binding (complement) type cysteine- rich repeats, (b) epidermal growth factor (EGF) recep- tor–like ...
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Adipocytes modulate vascular smooth muscle cells migration potential through their secretions
... Obesity and type 2 diabetes (T2D) are recognized as predisposition factors for atherosclerosis development. Endothelial cells (EC) and vascular smooth muscle cells (VSMC) are sensitive to obesity-linked increased ...
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Characterization of immortalized MARCO and SR-AI/II-deficient murine alveolar macrophage cell lines
... trose (10 mM) and HEPES (20 mM), adding CaCl 2 (0.3 mM) and MgCl 2 (1.0 mM). In a 96-well ultra low adher- ent plate (Corning Inc., Corning, NY): fifty microliters of macrophages (100K cells) were mixed with 50 μl of TiO ...
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Scavenger Receptor CD163 and Its Biological Functions
... a scavenger of haptoglobin/hemoglobin complexes preventing the he- moglobin intoxication and toxic effects of free ...endocytic receptor selectively expressed in machropages can be used for macrophage tar- ...
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Receptor recognition of maleyl albumin induces chemotaxis in human monocytes
... We demonstrate here that the exceptionally active maleyl-albumin receptor of human monocytes functions in vitro as a chemoattractant receptor. Chemotaxis of human monocytes occurs at an effective median ...
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The Tight Junction-Associated Protein Occludin Is Required for a Postbinding Step in Hepatitis C Virus Entry and Infection
... It has been suggested that the precise localization of HCV (co)receptors and their coordinate interactions with different proteins are required for productive HCV infection (11). In this context, we investigated whether ...
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