sciatic nerve ligation
PUNICA GRANATUM ATTENUATES SCIATIC NERVE LIGATION INDUCED NEUROPATHIC PAIN
... in sciatic nerve ligation induced-neuropathic pain in ...with sciatic nerve ligation to develop neuropathic pain in ...of sciatic nerve was assessed using the ...
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Analgesic and Anti-allodynic Effects of Two Flavonoids in Partial Sciatic Nerve Ligation in Rat Model
... Partial Sciatic Nerve Ligation; CNS: Central Nervous System; NSAIDs: Non-Steroidal Anti-Inflam- matory Drugs; COX-2: Cyclooxygenase-2; TNF- α : Tumour Necrosis Factor-α; IL-1 β : Interleukin-1β; IL-6: ...
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Neuropharmacological Assessment of Desmodium Gangeticum in Partial Sciatic Nerve Ligation in Rat Model: Role of Inflammatory Mediators
... peripheral nerve injury, there is a prominent sprouting of large afferents dorsally from lamina III into laminae I and ...peripheral nerve injury, these large afferents gain access to spinal regions ...
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<p>Partial sciatic nerve ligation leads to an upregulation of Ni<sup>2+</sup>-resistant T-type Ca<sup>2+</sup> currents in capsaicin-responsive nociceptive dorsal root ganglion neurons</p>
... Mice were first habituated to the experimental setup for > 1 hour during 3 consecutive days. After the habituation period, baseline responses of both hindpaws were measured using the von Frey test. The von Frey ...
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THE ANALGESIC EFFECT OF PREGABALIN, A COMPARATIVE STUDY WITH MORPHINE
... Results: The result of the present study revealed that neither 30 nor 60 mg/kg pregabalin produced any significant effects on the tolerability of rats to acute thermal pain. On the other hand, pregabalin (30 and 60 ...
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A Study of Acute and Chronic Anti-Nociceptive and Anti-Inflammatory Effects of Thiamine in Mice
... by sciatic nerve ...mg/kg. Sciatic nerve was exposed by cutting the right leg femoral ...the sciatic nerve was only exposed, not ...
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Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons
... a sciatic nerve ligation model by tying a tight ligature around approximately one-third to one-half the diameter of the sciatic ...with nerve ligation, we confirmed an increase ...
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Original Article Down-regulation of GAP-43 by inhibition of caspases-3 in a rat model of neuropathic pain
... the nerve injury model, the GAP-43 expression is up-regulated accompanied by nerve ...rat sciatic nerve was ligated to induce the neuropathic ...with ligation was significantly ...
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Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury
... Partial sciatic nerve ligation (PSNL) is a commonly used animal model for studying mechanisms underlying neuropathic pain ...sensory nerve endings project [2]. Indeed, at the cellular level, ...
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Local Peripheral Effects of β Caryophyllene through CB2 Receptors in Neuropathic Pain in Mice
... β-Caryophyllene (BCP) is known as a common constitute of the essential oils of numerous food plants and primary component in Cannabis. In this study, we investigated the effect of local intraplantar (i.pl.) injection of ...
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Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury
... as nerve and vas- cular regeneration, and EXOs derived from Schwann cells, macrophages, and MSCs can promote peripheral nerve re- generation [24 – ...rat sciatic nerve crush (SNC) ...optic ...
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Compression of the peroneal nerve by a neurofibroma originating from collaterals of the peroneal nerve: a case report
... impairment of his left lower limb that developed after a football game. No particular sprain or accident had oc- curred. A clinical examination revealed slight lameness without visible muscular atrophy. Muscular testing ...
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AMELIORATIVE EFFECTS OF TINOSPORA CORDIFOLIA IN SCIATICA PAIN INDUCED RATS
... Upon ligation the foot deformation occurred in all ...attenuated sciatic nerve root ligation-induced increase in spinal cold sensitivity, assessed by tail withdrawal latency time, in a ...
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Evaluation of the analgesic effect of Umbellipreninand Umbelliprenin-morphine co-administration on the acute, chronic and neuropathic pain
... Data was analyzed using Graph Pad Prism 5.00. One- way ANOVA followed by Newman-Keuls test to situ- ations the potential differences was done. We used unpaired T test for comparison between control animals and the ...
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Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies
... Background: Glutamate excitotoxicity is thought to be involved in the pathogenesis of neurodegenerative disease. One potential source of glutamate is N-acetyl-aspartyl-glutamate (NAAG) which is hydrolyzed to glutamate ...
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Combined posterior lumbar plexus–sciatic nerve block versus combined femoral–obturator–sciatic nerve block for ACL reconstruction
... The area of needle insertion is prepared and draped in a sterile manner. In the awake patient, a wheal of local anes- thetic is placed and a six inch 22-gauge Stimuplex insulated needle is advanced perpendicular to the ...
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Wallerian Degeneration in the Rat
... The observation that the concentrations of both nucleic acid and phospholipid in the sciatic nerve of the rat are negatively correlated with the wet weight of the nerve is in agreement w[r] ...
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Walking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat
... the sciatic nerve, rodents fre- quently scratch and bite their anaesthetised foot, re- sulting in amputation of one or more toes (especially the last two ...
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Gelatin-methacrylamide gel loaded with microspheres to deliver GDNF in bilayer collagen conduit promoting sciatic nerve growth
... For nerve regeneration, the main obstacle is to restore the function of the target ...each nerve regeneration group could evoke CMAPs with varying degrees, and function of target organ could be ...
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The Role of NLRP3 in Repairing Sciatic Nerve Injury
... the sciatic nerve and then closed the ...right sciatic nerves of the two groups of mice were removed at 4h, 24h and 48h after ...the sciatic nerve. The sciatic nerve was ...
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