sciatic nerves
Knockdown of Dock7 in vivo specifically affects myelination by Schwann cells and increases myelin thickness in sciatic nerves without affecting axon thickness
... In this study, we succeeded in generating Dock7 shRNA transgenic mice that exhibit enhanced myelin thickness in sciatic nerves without reduced axon diameters. We previously reported that Dock7 shRNA ...
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FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
... of sciatic nerves (four rats/group) were then collected and fixed overnight with ...per sciatic nerve were randomly analyzed and divided in two groups according to their normal size distri- bution in ...
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RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue
... Consistent with this hypothesis, we re- cently demonstrated that in C57BL/6-SOD1 G93A mice there was a prominent immune response in the motor neurons and sciatic nerves compared to a var[r] ...
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NEUROPROTECTIVE AND ANTIOXIDANT ROLE OF PREGABALIN IN STREPTOZOTOCIN INDUCED NEUROTOXICITY
... in sciatic nerves 29 ...of sciatic pain models 30 ...rat sciatic nerves and scavenged the free radicals responsible for nerve ...peripheral nerves is also contributing to anti ...
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Receptor-Dependent and -Independent Axonal Retrograde Transport of Poliovirus in Motor Neurons
... the sciatic nerves of PV-sensitive Tg mice after intramuscular inoculation with PV were mainly composed of intact 160S ...the sciatic nerves of PV-sensitive Tg mice as intact particles in an ...
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Zinc-finger transcription factors in the Schwann cell lineage
... wildtype nerves and ...mutant nerves. In the adult nerves isolated from either animal, BrdU positive nuclei were not ...mutant nerves at each stage were not statistically significant ...in ...
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Counteracting roles of MHCI and CD8+ T cells in the peripheral and central nervous system of ALS SOD1G93A mice
... radial nerves of mSOD1 mice were less susceptible to stress than the sciatic nerves of the same ...radial nerves of mSOD1 mice compared to sciatic nerves at the symptomatic ...
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Schwann cell–derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment
... affected nerves of SAPP mice and patients with ...Postn-deficient sciatic nerves show reduced Chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barre syndrome (GBS) are ...
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Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI
... peroneal nerves, with cautious sparing of the sural nerve; the sham rats underwent a surgery similar to SNI rats but without nerve injury; and the controls were left as naive rats ...the sciatic ...
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Gadolinium DTPA Enhancement Characteristics of the Rat Sciatic Nerve after Crush Injury at 4 7T
... left sciatic nerve was surgically exposed and crushed at the level of the midfemur by using either surgical forceps (n ⫽ 14) or a microvascular/microaneurysm clip (n ⫽ ...right sciatic nerve in 4 animals; ...
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Accumulation of Fascin+ cells during experimental autoimmune neuritis
... cut into two equally long segments. All of these segments were embedded in paraffin, sectioned serially (3 μm) and mounted on silane-covered slides. IHC was performed on 3 μm paraffin-embedded sections using purified ...
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Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages
... left sciatic nerve were made on day 16 post-immunization ...of sciatic nerves, as previously described ...the sciatic nerve and record the signals, ...left sciatic nerve from the hip ...
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Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy
... Mistletoe extracts were already used in broad spec- trums as remedying agents [37, 38]. Based on the activa- tion of the Akt signaling pathway and AMPK, we speculated that mistletoe extract could regulate cellular ...
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... the sciatic nerve while the wild type mice did ...the sciatic nerve in wild type and SLPI KO mice and attempted to identify the origin of the aberrant ...the sciatic nerve, and that the vessels are ...
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Immune response in peripheral axons delays disease progression in SOD1G93A mice
... and sciatic nerves of ALS ...the sciatic nerve of C57SOD1 G93A mice than the Ntg littermates at disease onset ...the sciatic nerves of the C57SOD1 G93A mice ...the sciatic nerve ...
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Interleukin 12: A Potential Link between Nerve Cells and the Immune Response in Inflammatory Disorders
... cluded neonatal and adult BB-Wistar rats, and consisted of foot pad skin, sural and sciatic nerves, dorsal and sympathetic ganglion cells, spinal cord, and brain.. Tissue samples were im[r] ...
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Protective Effects of Combined Therapy of Rutin with Silymarin on Experimentally Induced Diabetic Neuropathy in Rats
... Effect on Lipid Peroxidation Bio-Markers Lipid peroxidation LPD bio-markers such as TBARS levels showed significantly P < 0.001 increased in sciatic nerves of diabetic rats while GSH lev[r] ...
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Biological behavior of mesenchymal stem cells on poly-ε-caprolactone filaments and a strategy for tissue engineering of segments of the peripheral nerves
... Ipsilateral sciatic nerves, DRGs (L5), lumbar spinal cord, and gastrocnemius muscles were removed and kept in a 30 % sucrose solution in phosphate buffer for 48 ...The nerves had the epineurium ...
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NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo
... Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically induced depletion of NMNAT2 triggers axonal degeneration or defective axon growth. We have previously pro- posed that axonal ...
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Electrophysiologic alterations in the excitability of the sciatic and vagus nerves during early stages of sepsis
... of sciatic nerves from CLP- operated rats compared to sham-operated rats (Figure ...in sciatic nerves during the early phase of sepsis, before the appearance of clinical signs of gross ...
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