SCID-hu
Coinfection of SCID-hu Thy/Liv Mice with Human Herpesvirus 6 and Human Immunodeficiency Virus Type 1
... that SCID-hu Thy/Liv mice are per- missive for HHV-6 replication and may represent a useful model to elucidate the immunosuppressive mechanisms of this virus ...(9). SCID-hu Thy/Liv mice are a ...
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Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice.
... The SCID-hu mouse is a unique in vivo system which per- mits evaluation of HIV pathogenicity in the absence of a host immune ...The SCID-hu mouse is constructed by the surgical implantation of ...
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Attenuation of the Vaccine Oka Strain of Varicella-Zoster Virus and Role of Glycoprotein C in Alphaherpesvirus Virulence Demonstrated in the SCID-hu Mouse
... The SCID-hu mouse implanted with human fetal tissue is a novel model for investigating human viral ...the SCID-hu model revealed differences in tropism for human cells that correlated with ...
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Human Immunodeficiency Virus Type 1 Pathogenesis in SCID-hu Mice Correlates with Syncytium-Inducing Phenotype and Viral Replication
... GHOST (3) cells were used to map the coreceptor specificity of the patient-derived chimeric molecular clones we con- structed. Consistent with other reports, we found that all of these clade B isolates could infect ...
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Tropism of varicella-zoster virus for human CD4+ and CD8+ T lymphocytes and epidermal cells in SCID-hu mice.
... using SCID-hu mice that carry human fetal thymus/liver implants under the kidney capsule or as subcutaneous fetal skin ...the SCID-hu model for studies of VZV ...
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Proteasome inhibition reduces superantigen mediated T cell activation and the severity of psoriasis in a SCID hu model
... The SCID-hu xenogeneic transplantation model employed in our in vivo studies is a well-established tool for the investigation of various aspects of the pathogenesis of psoriasis as well as for the screening ...
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Resistance to Replication of Human Immunodeficiency Virus Challenge in SCID-Hu Mice Engrafted with Peripheral Blood Mononuclear Cells of Nonprogressors Is Mediated by CD8+T Cells and Associated with a Proliferative Response to p24 Antigen
... The data from this study establish this resistance phenotype in a unique subgroup of nonprogressors that likely make up less than 0.8% of the HIV-infected population. These patients are characterized by nonprogressive ...
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Impaired Surfactant Production by Alveolar Epithelial Cells in a SCID-hu Lung Mouse Model of Congenital Human Cytomegalovirus Infection
... Human cytomegalovirus (HCMV) is the leading viral cause of birth defects and life-threatening lung-associated diseases in pre- mature infants and immunocompromised children. Although the fetal lung is a major target ...
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Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice
... the SCID-hu thymus/liver model system. The SCID-hu (thymus/liver) mouse is created by surgical implantation of human fetal thymus and liver tissue into SCID mice ...in ...
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Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis.
... in SCID-hu mice and did so without productive infection of ...cells. SCID-hu mice have also been instructive for the study of HIV (2, 9, 27, 33, 45), CMV (29), and varicella-zoster virus (31), ...
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Rapid-high, syncytium-inducing isolates of human immunodeficiency virus type 1 induce cytopathicity in the human thymus of the SCID-hu mouse.
... SCID-hu a Thy/Liv aEach number represents data obtained from single the NSI isolate A6/87 n = 7, 82% ± 2% with the mean "Comparing the mean percentage of CD4+ CD8' cells remaining at= 4 [r] ...
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Epstein Barr virus induces aggressive lymphoproliferative disorders of human B cell origin in SCID/hu chimeric mice
... development (within 19-33 d) of aggressive, fatal, lymphoproliferative disorders of human B cell origin. Autopsies revealed solid tumors in the abdomen, and occasionally in the liver, thymus, or spleen. Histopathologic ...
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T-Cell Tropism and the Role of ORF66 Protein in Pathogenesis of Varicella-Zoster Virus Infection
... Varicella-zoster virus (VZV) is an alphaherpesvirus that causes chicken pox, or varicella, establishes lifelong latency in the sensory ganglia, and later reactivates to cause shingles, or herpes zoster. The pathogenesis ...
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Human Immunodeficiency Virus Type 1 IIIB Selected for Replication In Vivo Exhibits Increased Envelope Glycoproteins in Virions without Alteration in Coreceptor Usage: Separation of In Vivo Replication from Macrophage Tropism
... of SCID-hu Thy/Liv mice or ...for SCID-hu Thy/Liv construction have been described previously ...of SCID-Thy/Liv mice was performed as previously described ...Briefly, ...
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Expression and Function of Chemokine Receptors on Human Thymocytes: Implications for Infection by Human Immunodeficiency Virus Type 1
... from SCID-hu ...(B) SCID-hu thymus-liver graft cells were isolated and incu- bated with CD4-peridinin chlorophyll protein, CD8-FITC, anti-CCR5- APC, anti-CXCR4-PE, or isotype control MAb ...
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Mechanism of human immunodeficiency virus type 1 localization in CD4-negative thymocytes: differentiation from a CD4-positive precursor allows productive infection.
... the SCID-hu mouse causes a rapid and severe depletion of CD4-bearing thymocytes (2, 4, ...in SCID-hu mice, indicate that late in infection of the human thymus, CD8 SP thymocytes harbor and ...
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Biochemical and functional characterization of xenoreactive natural antibodies in hu PBL SCID mice
... leukocyte-reconstituted SCID (hu-PBL-SCID) ...of hu-PBL-SCID by ELISA and flowcytometric ...from hu-PBL-SCID recognized xenoantigens with similar molecular mass as those ...
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Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages
... Human T lymphocytes and macrophages are the major host cells for HIV-1 replication. The initial infection is established by macrophage tropic viruses (R5) that use the chemokine receptor CCR5 and CD4 to gain entry into a ...
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The utilization of humanized mouse models for the study of human retroviral infections
... The SCID-hu Thy/Liv mouse was accompanied by the development of the SCID-hu PBL (humanized-peripheral blood lymphocyte) mouse model, generated by the ...into SCID mice ...the ...
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Financial Instruments for Enterprises - Final Report : Ex post evaluation of Cohesion Policy programmes 2007 - 2013, focusing on the European Regional Development Fund (ERDF) and the Cohesion Fund (CF)
... Appraisal of the operational objectives of OP priorities within which FIs were implemented suggests that almost all of them were achieved, 70% to a high degree. For the strategic objectives (related to the regional ...
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