SD Rats
Cytotoxicity and sub acute toxicity in Crl:CD (SD) rats of traditional herbal formula Ojeok san
... In experimental studies, OJS has been reported to have several biochemical activities such as anti-cancer [2], anti- inflammation [3,4], anti-hyperglycemia [5], anti-clastogenic effect [6] and immune regulation [7]. In ...
9
Aqueous extracts of Liriope platyphylla induced significant laxative effects on loperamide induced constipation of SD rats
... No-treated rats (Figure 3), which is agreement with the results of previ- ous reports [23,41] and may validate the present his- tochemical ...Lop-treated SD rats, but was recovered in Lop + ...
12
Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats
... in SD rats by subcutaneous injection of Lop (4 mg/kg weight) in ...8-week-old SD rats ( n = 30) were assigned to either a non-constipation group ( n = 12) or a constipation group ( n = ...
9
Investigation of Gender Difference of Physiological Response in Gonadectomy in Sprague-Dawley (SD) Rats
... SD rats were purchased from CLEA Japan, Inc. (Tokyo, Japan). Rats were housed in suspended bracket cages and given a standard laboratory diet (CRF-1, Oriental yeast ...female rats were ...
8
Protective Effects of α Tocopherol against Brain Tissue Damage Induced by Intracerebral Hemorrhage in SD Rats
... use SD rats to carry out the related studies; based on the atlas of SD rats, the caudate nucleus was posi- tioned using a stereotaxic apparatus, and 50 μl autologous tail artery blood was ...
13
Original Article Transcriptomic analysis of dracorhodin perchlorate intervention in wound healing in SD rats
... diameters of approximately 10 mm, were cre- ated using a sterilized puncher. The drug- administered group was treated with DP oint- ment, while the control group was treated with Vaseline ointment for 7 days. Animals ...
13
EFFECT OF ZONISAMIDE ON CHRONIC CONSTRICTION INJURY INDUCED NEUROPATHIC PAIN IN MALE SD RATS
... This study examined the potential therapeutic value of Na + and T-type calcium channel blocker ‘zonisamide’ in the treatment of neuropathic pain using the CCI model of experimental neuropathy. Zonisamide inhibits ...
11
Effect of Chronic DL Amphetamine Exposure on Brain Volume, Anxiogenic, Locomotor, and Social Behaviors in Male SD Rats
... Research examining the long-term effects of drugs such as Adderall™, a mixed DL-amphetamine, as a first-line treatment strategy for those diagnosed with attention deficit hyperactivity disorder (ADHD), is very much ...
10
Regulation and analysis of the diversity of intestinal microbiota in SD rats by Danggui Buxue Tang (DBT) fermented with Bacillus subtilis
... in rats induced by trinitrobenzene sulfonic acid using a red ginseng decoction, the num- ber of beneficial bacteria in the intestines of rats, such as Bifidobacterium animalis, ...
8
GASTROPROTECTIVE EFFECT OF ACANTHOPANAX TRIFOLIATUS ON EXPERIMENTALLY INDUCED ACUTE ULCER IN RATS
... (SD) rats and to determine the possible involvement of either suflhydryl group or nitric oxide group in it’s ...of SD rats induced by absolute ethanol at dose 300 mg/kg with a tendency for the ...
14
Original Article Effect of histological prostate inflammation on erectile function and its possible mechanism:
... (SD) rats, the erectile function, ratio of maximum intracavernosal pressure (ICP)/mean arterial pressure (MAP), enzyme ac- tivity of endothelial nitric oxide synthase (eNOS), cyclic guanosine monophosphate ...
6
Expression Imbalance of Cholinergic M2 and M3 Receptors Contributes to the Motility Reduction of the Small Intestine in Spleen Qi Deficiency
... male SD rats were randomly divided in the control group and spleen qi deficiency group (model group)—8 rats each group; spleen qi deficiency model of the improper diet and overfatigue was ...
6
Preclinical safety assessment and mutagenicity of the hydroethanolic extract of Syzygium campanulatum leaves.
... female SD rats weighing 200–220 g using the aqueous solution of HESCL at the limit dose of 5000 mg/kg against vehicle-treated ( 10 ml/kg ) control group in accordance with the published ...female ...
11
Telmisartan is effective to ameliorate metabolic syndrome in rat model – a preclinical report
... column), SD rats fed normal diet; Con+Tel (white column), SD rats fed normal diet and administered with telmisartan (8mg/kg); Veh (black column), MS rats received with vehicle; Veh+Tel ...
11
In vitro and in vivo effect of Eurycoma longifolia root extract on UDP-glucuronosyltransferase activity
... ELE extract decreased UGT activity significantly in vitro, while in the in vivo study, the ELE decreased UGT activity both for acute (1-day treatment) or sub-acute (14-day treatment) studies. The sub-acute result was in ...
7
Original Article Effects of hydroxysafflor yellow A on proliferation and collagen synthesis of rat vascular adventitial fibroblasts induced by angiotensin II
... (SD) rats in vitro, and 2) to assess the effects of HSYA on morphological changes and collagen accumulation of vascular adventitia in spontaneously hypertensive rats (SHR) in ...from SD ...
10
Original Article The effects of Porphyromonas gingivalis on the apoptosis of hippocampal cells in Sprague-Dawley rats and its underlying mechanisms
... Intracellular calcium overload caused by excitatory amino acid toxicity can induce apop- tosis, which is one of the me- chanisms of apoptosis in brain tissue and is associated with a variety of neurodegenerative ...
10
Original Article Activation of SHH signaling pathway promotes vasculogenesis in post-myocardial ischemic-reperfusion injury
... In this study, we using SD rats isolated cardiac microvascular endothelial cells (CMECs) to investigate the potential roles in SHH signal on vasculogenesis during MIRI. A variety of experi- mental methods ...
9
Erratum to: cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways
... Figure 4 Quantitative PCR analysis of selected proliferation- related genes. Relative amount of mRNA of PCNA (A), Ki67 (B) and c-myc (C) as analysed by quantitative PCR analysis of whole kidney homogenates of PKD2 ...
6
Original Article Are there differences between Sprague-Dawley and Wistar rats in long-term effects of ovariectomy as a model for postmenopausal osteoporosis?
... the SD and Wistar rats of the OVX and Sham groups subsequently disappeared, sug- gesting that the effect of estrogen deficiency was temporary and unstable ...in SD rats in both the OVX and ...
12