sE-selectin
Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome
... We found significantly elevated serum levels of sICAM-1, and sE-selectin in serum of both primary and secondary SS patients in comparison with healthy control. These findings could reflect hyperactivation ...
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Serum ICAM-1, VCAM-1 and E-selectin levels in patients with primary and secondary Sjögren’s syndrome
... and sE-se- lectin in patients with pSS and sSS have not yet been com- ...and sE-selectin levels as additional, supporting parameters in the diagnosis and determination of the disease and ...
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Mild-Tourniquet Induced Ischaemia-reperfusion Injury Results in Changes to Haematological, Haemostatic and Inflammatory Parameters
... Patients and Methods: An In vivo model of mild tourniquet induced IRI was performed on 15 volunteers (n=15). Tourniquet pressure was set between 20-40 mmHg for 10 minutes and rendered the arm temporarily ischaemic. ...
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Cardiovascular diseases-related GNB3 C825T polymorphism has a significant sex-specific effect on serum soluble E-selectin levels
... serum sE, sP and sL-selectins after adjusting for age, sex, body mass index, systolic blood pressure, anti-inflammatory drugs and hormonal drugs ...for sE-selectin ( p < ...serum sE- ...
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Early Clinical Markers for the Development of Bronchopulmonary Dysplasia: Soluble E-Selectin and ICAM-1
... sP- Selectin in cord blood samples were higher in infants born of mothers with maternal chorioamnionitis than in infants whose mothers were not diagnosed as having chorioamnionitis (data not ...of ...
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Cell adhesion molecules and exercise
... in sE-selectin, sVCAM-1, and sICAM-1 at the end of the race; however, these elevated CAMs returned to the pre-race values at 48 hours ...particularly sE- selectin and sICAM-1, in the ...
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Journal of Applied Pharmaceutical Science
... Eichbaum et al. (Eichbaum et al., 2004) investigated the value of soluble and solid states of E-selectin as a potential cancer biomarker for early detection, prognosis, and monitoring, they reported that ...
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A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection
... E- selectin is a cell adhesion molecule expressed and secreted by activated endothelial cells and is a component of an adhesion cascade that leads to leukocyte and plate- let accumulation at sites of inflammation, ...
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Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients
... elevated sE-selectin and sICAM-1 have been shown to activate leukocytes following neurological insult [24], whereas high sL-selectin levels are closely associated with decreased cellular interactions ...
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The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro
... results to the Caco-2 monoculture and no sE-selectin was detected in the supernatants. Thus, the epithelial cells formed a substantial barrier, even under inflammatory conditions, that prevent ...
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Anti-atherosclerotic effects of sitagliptin in patients with type 2 diabetes mellitus
... sP-selectin, sE-selectin, sVCAM-1, and monocyte chemoattractant protein-1 (MCP-1) were measured using monoclonal antibody-based ELISA kits (Invitrogen ...
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Examination of biomarker expressions in sepsis-related DIC patients
... (sP-selectin), sE-selectin, sL-selectin, sVCAM-1, and soluble CD40 ligand (sCD40L) were measured using monoclonal antibody-based ELISA kits (Invitrogen ...
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The association between serum adhesion molecules and outcome in acute spontaneous intracerebral hemorrhage
... The present study examines the corrections between outcome and endothelial cell activation markers follow- ing spontaneous ICH and produces the following major findings. First, sICAM-1 and sVCAM-1 concentrations markedly ...
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Fenofibrate improves endothelial function and plasma myeloperoxidase in patients with type 2 diabetes mellitus: an open-label interventional study
... Methods: 27 patients (14 men and 13 women) with T2DM and good glycemic control (HbA1c: min 5.9%, max: 7.1%) treated with metformin monotherapy, without previous use of lipid-lowering medication were enrolled in this ...
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Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion
... postcapillary venules with reduced (30-50%) shear rates. The increased rolling was also reduced 60% by either an anti-P-selectin antibody, an anti-L-selectin antibody, or a combination of the two ...
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Inflammatory roles of P selectin
... interactions. In addition, PMNs adherent to endothelium expressing P-selectin demonstrate an intracellular Ca2+ transient, functionally up-regulate beta-2-integrins (CD11/CD18 glycoproteins), become polarized in ...
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Selectin mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas
... We and others have shown that heparin can inhibit P- and L-selectin recognition of ligands (54–59) and that heparin blockade of tumor metastasis is at least partly explained by selectin inhibition, rather ...
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Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis
... As this review illustrates, dysregulation of angiogenesis is an important process in the pathogenesis of various rheumatic diseases, including RA and SSc. In RA angiogenesis is central to the formation of the ...
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P selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P selectin in inflammation
... P-selectin is a leukocyte adhesion receptor present in endothelial cells and platelets. We examined the role of P-selectin in the autologous phase of an accelerated model of anti-glomerular basement mem- ...
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Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents
... against selectin–PSGL-1 interactions are so close to or even above the recommended target range for anti- coagulation that the degree of selectin inhibition in a given pa- tient would be hard to ...this ...
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