second-line
The Timing and Probability of Switching to Second line Regimen An application to Second Line Antiretroviral Therapy in India
... the second-line treatment as soon as possible, which is precisely when the second-line treatment is least ...and second-line ...in second-line treatments that are ...
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Second-Line Chemotherapy of Advanced Colorectal Cancer: Predictive and Prognostic Factors
... In the evaluation of the concomitant dis- eases prior to treatment, dysfunction of kid- neys, liver and cardiovascular, endocrine and haemopoetic system were taken into account. The evaluated variables included blood ...
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Outcome of patients on second line antiretroviral therapy under programmatic condition in India
... 6 months of second line therapy. Plasma samples stored at −70 °C were used for detection of HIVDR mutations by in-house assay described in a previous study [9]. RNA extraction from plasma samples were ...
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Detection of second line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays
... This report describes a rapid microarray technique to detect the resistance to FQs and second-line injectable drugs (KAN and CAP) in MTB. This technique is the perfect complement to the TB-Biochip test for ...
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Effectiveness and tolerability of second-line treatment with vildagliptin versus other oral drugs for type 2 diabetes in a real-world setting in the Middle East: results from the EDGE study
... whom second-line oral glucose- lowering therapy was initiated, vildagliptin resulted in low- ering HbA 1c to ...with second-line OAD as suggested by a high baseline HbA 1c at time of ...
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Second-line docetaxel-based chemotherapy after failure of fluorouracil-based first-line treatment for advanced esophageal squamous cell carcinoma
... standard second-line therapy has emerged until now. Docetaxel demonstrated good efficacy and is widely used in several solid tumors. More recently, these newer agents have been evaluated as a single agent or ...
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Use of carfilzomib in second-line therapy and beyond for relapsed multiple myeloma
... a second-generation proteasome inhibitor with irreversible binding to proteasome and less off-target ...as second-line therapy in multiple ...
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Frequency and patterns of second-line resistance conferring mutations among MDR-TB isolates resistant to a second-line drug from eSwatini, Somalia and Uganda (2014–2016)
... a second-line anti-TB drug was confirmed in the period between September 2014 and July 2016, Add- itional file 1: Table ...to second-line drugs in those countries [22], see references [23, 25] ...
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Outcomes of second line combination antiretroviral therapy for HIV infected patients: a cohort study from Rio de Janeiro, Brazil
... starting second-line ...developed second- line cART virologic failure had a resistance testing performed at second-line ...at second-line virologic ...
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Comparison of second-line therapy in IVIg-refractory Kawasaki disease: a systematic review
... Data were combined and grouped by second-line ther- apy. Because studies meeting inclusion criteria were not restricted to comparative studies, we first summarized the proportion of observed outcomes for ...
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The role of second-line chemotherapy in small cell lung cancer: a retrospective analysis
... administered second-line chemotherapy lived significantly longer, with a median survival of 422 days compared to 228 days in patients with best supportive care alone ...as second-line ...
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Maximising clinical benefit with adequate patient management beyond the second line in mCRC
... Based on available efficacy data, treatment with either trifluridine/tipiracil or regorafenib is an appropriate first choice beyond second-line therapy to support improvements in OS in patients with mCRC. ...
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Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer
... during or after docetaxel treatment. The TROPIC trial showed a significant overall survival advantage of 2.4 months using second-line cabazitaxel over mitoxantrone in such patients. Because of the large ...
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Raltitrexed + irinotecan as second line chemotherapy in elderly patients with advanced colorectal cancer
... reporting severe neutropenia in 34% of the patients treated once every 3 weeks and in 25% of those treated weekly , also supports the idea that these differences in toxicity profile are probably related to the ...
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Virologic outcomes of second-line antiretroviral therapy in Eastern European country of Georgia
... The reported rates of mortality among patients on second-line ART varied substantially, ranging from 3% to 16% [18-21]. In our study 11% of patients died over the follow-up, including four patients died ...
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Survival analysis in second-line and third-line chemotherapy with irinotecan followed by topotecan or topotecan followed by irinotecan for extensive-stage small-cell lung cancer patients: a single-center retrospective study
... The number of cycles, tumor response to chemotherapy, and duration of first-line, second-line, and third-line of chemotherapy, OS, and disease control rates (DCRs) were recorded. DCR is ...
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First-line and second-line treatment of patients with metastatic pancreatic adenocarcinoma in routine clinical practice across Europe: a retrospective, observational chart review study
... regarding second- line treatment was avail- able for 1666 of the 2565 patients evaluated in this study (table ...first- line treatment and did not continue treatment. After completing second- ...
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Comparative analysis of appropriate second line therapies for management of severe postpartum hemorrhage – a prospective study
... First line treatment of PPH include the manual removal of retained placental tissue, uterine massage, application of bimanual compression, continuous intravenous application of oxytocin and volume ...first ...
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Optimal first-line and second-line treatments for metastatic renal cell carcinoma: current evidence
... alternatives include sunitinib and bevacizumab combined with interferon, based on the minimal inclusion of poor- risk patients in the pivotal Phase III studies of these two molecules. In patients with non-clear cell ...
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Original Article Comprehensive analysis of lung adenocarcinoma patients with gefitinib as first-line, second-line and third-line treatment
... men, second-line regimen, third- line regimen was 14, 24, 3, respectively; drug related to adverse effects were diarrhea and rash, 11 cases ...
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