Second-Line Chemotherapy
<p>Impact of Amrubicin Monotherapy as Second-Line Chemotherapy on Outcomes in Elderly Patients with Relapsed Extensive-Disease Small-Cell Lung Cancer</p>
... trial (IMpower-133) demonstrated that adding an immune checkpoint inhibitor (atezolizumab) to CE improved both progression-free survival (PFS) and overall survival (OS). 7 The synthetic prodrug amrubicin (AMR) ...
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Raltitrexed + irinotecan as second line chemotherapy in elderly patients with advanced colorectal cancer
... a second-line chemotherapy in elderly pa- tients (>70 years) with advanced colorectal can- cer after failure of oxaliplatin based chemothera- py twenty-three patients were ...
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The prognostic value of D-dimer levels in metastatic osteosarcoma patients treated with second-line chemotherapy
... All statistical analyses were performed using the SPSS statistical software (Version 19.0, IBM Corp.). D-dimer levels were presented as the mean ± standard deviation and compared using Wilcoxon signed-rank tests. OS was ...
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The role of second-line chemotherapy in small cell lung cancer: a retrospective analysis
... received second-line chemotherapy and 535 continued with best supportive care (BSC) treatment, and there was a great survival benefit for the second-line group compared with the BSC ...
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Second-Line Chemotherapy of Advanced Colorectal Cancer: Predictive and Prognostic Factors
... In the evaluation of the concomitant dis- eases prior to treatment, dysfunction of kid- neys, liver and cardiovascular, endocrine and haemopoetic system were taken into account. The evaluated variables included blood ...
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Advanced biliary tract carcinomas: a retrospective multicenter analysis of first and second-line chemotherapy
... Background: Gemcitabine/Cisplatin (Gem/CDDP) combination has demonstrated a clear survival advantage over gemcitabine alone and has become a new standard in advanced Biliary Tract Carcinoma (aBTC). However, ...
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Survival of patients with metastatic HER2 positive gastro-oesophageal cancer treated with second-line chemotherapy plus trastuzumab or ramucirumab after progression on front-line chemotherapy plus trastuzumab
... by second-line treatment with either CT or ...starting second- line therapy, were excluded from our ...of second-line therapy, disease site and duration of first-line ...
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Gemcitabine and docetaxel as second-line chemotherapy in elderly patients with metastatic urothelial carcinoma: a retrospective analysis
... of second-line GD therapy was a strong prognostic factor for PFS and ...discontinuing chemotherapy entirely among those who are unable to tolerate full-dose therapy, elderly patients with mUC aged ≥ ...
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Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib: a case report
... and second-line chemotherapy for locally advanced or metastatic soft tissue sarcomas in adults: a study of the european organization for research and treatment of cancer soft tis- sue and bone ...
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Triplet chemotherapy with paclitaxel, gemcitabine, and cisplatin as second line therapy for advanced urothelial carcinoma
... chemotherapy. Bellmunt et al., showed that the presence of liver metastasis, poor ECOG-PS, and low Hb levels were significant risk factors for poor prognosis in pa- tients with second-line vinflunine ...
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Prognostic Value of Neutrophil Lymphocyte Ratio in Second Line Advanced Malignant Pleural Mesothelioma
... the second line chemotherapy which deserves validation by prospective studies including a larger number of pa- tients, furthermore it may have a therapeutic implication through the possible targeting ...
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Critical appraisal of pemetrexed in the treatment of NSCLC and metastatic pulmonary nodules
... cytotoxic chemotherapy should be stopped at disease progression or after 4 cycles, in patients whose disease is stable but not responding to ...single-agent chemotherapy may be considered, such as ...
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Second-line docetaxel-based chemotherapy after failure of fluorouracil-based first-line treatment for advanced esophageal squamous cell carcinoma
... standard second-line therapy has emerged until now. Docetaxel demonstrated good efficacy and is widely used in several solid tumors. More recently, these newer agents have been evaluated as a single agent or ...
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Original Article Docetaxel-based doublet versus pemetrexed-based doublet as second-line therapy in TKI treated advanced NSCLC patients with EGFR mutations: a multicenter retrospective study
... Abstract: This research aimed to investigate the effectiveness and safety of docetaxel-based versus pemetrexed- based doublet as second-line therapy in TKI treated NSCLC patients with EGFR mutations. ...
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Chemotherapy with or without pemetrexed as second-line regimens for advanced non-small-cell lung cancer patients who have progressed after first-line EGFR TKIs: a systematic review and meta-analysis
... to second-line chemotherapy ...combination chemotherapy (Table ...cytotoxic chemotherapy singlet (eg, docetaxel singlet) or doublet (eg, platinum doublet, navelbine/platinum doublet and ...
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Small-cell neuroendocrine carcinoma of the ileum: case report and literature review
... disease, debulking or cytoreductive surgery and surgical resection of metastatic lesions are not recommended [11, 12]. The adjuvant treatment of the NEC is similar to the SCLC chemotherapeutic agents. The utilization of ...
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Monoclonal antibodies and Fc fragments for treating solid tumors
... Necitumumab (IMC-11F8) is an EGFR-targeting IgG1 mAb which is currently being evaluated in two phase III trials for treating nonsquamous stage IIIB or IV nonsmall cell lung cancer. An open-labeled, randomized, ...
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Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR 02): an open label, phase 3 randomised controlled trial
... Methods For this open-labelled, multicentre trial, we recruited patients aged 18 years or older from 30 UK centres. Patients were eligible if they had an advanced, histologically confi rmed adenocarcinoma of the ...
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Addition of rapamycin and hydroxychloroquine to metronomic chemotherapy as a second line treatment results in high salvage rates for refractory metastatic solid tumors: a pilot safety and effectiveness analysis in a small patient cohort
... self-controlled study indicated that such combinations were not only effective, but also could reverse drug resistance. The autophagy inducer and lysosomal inhibitor in combination with chemotherapy seem to work ...
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<p>A retrospective six-patient series of apatinib for the treatment of persistent or recurrent carcinoma of the cervix</p>
... important factor in some condition, particularly in developing countries. Although the bevacizumab was approved in as the fi rst line for cervical cancer based on the results of GOG240, this is currently only ...
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