Second line drugs
Evaluation of Pyrosequencing assay for the rapid detection of resistance to. Rifampicin and Second-line drugs in Mycobacterium tuberculosis clinical
... for the rapid detection of resistance to Rifampicin and Second-line drugs in Mycobacterium tuberculosis clinical isolates as compared to the gold standard conventional drug susceptibility testing.” ...
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The Application of the Therapeutic Drug Monitoring (TDM) of First and Second-Line Drugs for Multidrug-Resistant Tuberculosis Patients (MDRTB)
... Due to an unfamiliarity of TDM related to MDRTB in Thailand, there were still some limitations including numbers of experts in TDM skills, knowledge and skills, budget available, and the responsibility of both health ...
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Rapid Detection of Mycobacterium tuberculosis Resistance to Second Line Drugs by Use of the Manual Mycobacterium Growth Indicator Tube System
... Received 20 June 2008/Returned for modification 30 September 2008/Accepted 12 October 2008 The objective of this study was to evaluate the manual mycobacterium growth indicator tube (MGIT) system for the testing of ...
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A 24 well plate assay for simultaneous testing of first and second line drugs against Mycobacterium tuberculosis in a high endemic setting
... the second line drugs would be an important step in the development of the ...the second line drugs that there was perfect agreement in the H37Rv MIC distribution within 13 ...
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Detection by GenoType MTBDRsl Test of Complex Mechanisms of Resistance to Second Line Drugs and Ethambutol in Multidrug Resistant Mycobacterium tuberculosis Complex Isolates
... for second-line drugs, there is a major interest in rapid molecular detection methods for resistance to these ...and second-line drugs on patterns of MDR TB showing a wide range ...
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Multicenter Laboratory Validation of the BACTEC MGIT 960 Technique for Testing Susceptibilities of Mycobacterium tuberculosis to Classical Second Line Drugs and Newer Antimicrobials
... DISCUSSION Only a few publications reported in the literature deal with MICs of second-line drugs in the MGIT medium. These, how- ever, are not multicenter studies, and in addition, they focus on one ...
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Performance of the New Version (v2 0) of the GenoType MTBDRsl Test for Detection of Resistance to Second Line Drugs in Multidrug Resistant Mycobacterium tuberculosis Complex Strains
... DISCUSSION When MDR-TB is detected, the main therapeutic issue that must be addressed is that of determining the susceptibility of the strain to the remaining first-line drugs, to second-line ...
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The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)
... drug resistance is slow and can take several months. The resulting diagnostic delay results in unnecessary morbidity, mortality, and increased transmission, which is a major driver of new TB cases. There is a need for ...
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Diagnostic Accuracy and Reproducibility of WHO Endorsed Phenotypic Drug Susceptibility Testing Methods for First Line and Second Line Antituberculosis Drugs
... In an effort to update and clarify policies on tuberculosis drug susceptibility testing (DST), the World Health Organization (WHO) commissioned a systematic review evaluating WHO-endorsed diagnostic tests. We report the ...
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Detection of Resistance to Second Line Antituberculosis Drugs by Use of the Genotype MTBDRsl Assay: a Multicenter Evaluation and Feasibility Study
... Samara Oblast Tuberculosis Dispensary, Samara, Russia a ; Queen Mary College, Barts and the London School of Medicine, University of London, London, United Kingdom b ; Tartu University Hospital, Tartu, Estonia c ; ...
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Second-line glucose-lowering drugs added to metformin and the risk of hospitalization for heart failure: A nationwide cohort study
... Subgroup analysis using national health screening data The NHIS claims data included all physician-diagnosed disorders coded by ICD-10 but did not include objective data on exposure levels to CV risk factors. Therefore, ...
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Policy guidance on drug-susceptibility testing (DST) of second-line antituberculosis drugs World Health Organization Geneva 2008
... which drugs to test for resistance, based on the most appropriate strategy for designing treatment regimens and taking the above-mentioned constraints of SLD-DST into ...those drugs used in individual ...
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Comparison of line probe assay to BACTEC MGIT 960 system for susceptibility testing of first and second line anti tuberculosis drugs in a referral laboratory in South Africa
... different drugs means that this test should not be used to “rule out” resistance to second-line drugs but rather act as a rapid screening test for identifying second-line drug ...
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Diagnostic Performance of the New Version (v2 0) of GenoType MTBDRsl Assay for Detection of Resistance to Fluoroquinolones and Second Line Injectable Drugs: a Multicenter Study
... to second-line drugs, and it should be recommended in countries with a high burden of MDR/XDR-TB or in settings with high reported rates of resistance to ofloxacin in new and retreatment ...
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Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study
... Ethiopia initiated the first MDR-TB treatment in 2009 at St. Peter’s Specialized Hospital in Addis Ababa [20], and there has been a rapid scale-up of drug resistant TB care in recent years at the national and regional ...
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Multiple sclerosis disease-modifying drugs second line treatments
... describes second line treatment of relapsing-remitting multiple sclerosis with disease modifying drugs (DMDs), how they are given and some of their possible side ...
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GenoType® MTBDRsl assay for resistance to second-line anti-tuberculosis drugs
... Implications for research Future studies should evaluate MTBDRsl version 2.0 in particu- lar on smear-negative specimens and in different laboratory set- tings and populations (for example, in HIV-positive people). Test ...
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Prioritizing Second-Line Antiretroviral Drugs for Adults and Adolescents: a Public Health Approach
... In the COLATE study [20], 131 patients with virological failure on a 3TC-containing regimen were randomized to continued 3TC or no 3TC in addition to a salvage regimen chosen by their physician. Patients were stratified ...
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Patch testing for the management of hypersensitivity reactions to second line anti tuberculosis drugs: a case report
... starting second-line anti-tuberculosis treatment in Mumbai, ...All drugs were suspended and the patient was hospitalised for acute ...identify drugs that potentially caused the ...
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Second-Line Chemotherapy
... The activity of pemetrexed and cisplatin in the first-line setting and the apparent value of post-study chemotherapy within the context of that phase III study have confirmed the sensitivity of some mesotheliomas to ...
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