secretory phospholipase
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
... Secretory phospholipase A 2 (sPLA 2 ) is an enzyme that catalyzes the hydrolysis of ester bond at the sn-2 position of glycerophospholipids. The released fatty-acid, such as arachi- donic acid, may be ...
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Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: A 21 year cohort
... II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population ...
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Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin 1β induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
... (PIP)-18), secretory phospholipase A 2 (sPLA 2 ) inhibitor (LY315920) or matrix metalloproteinase inhibitor (MMP-II) at 5 μM for one hour, and incubated with hrIL-1β (10 ng/ml) for 24 hours before isolating ...
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Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2
... Endothelial protein C receptor (EPCR) is an endothelial transmembrane glycoprotein able to bind to a natural anticoagulant, protein C (PC), and its activated form, APC, with similar affinity [5]. Though originally ...
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ANTI INFLAMMATORY ACTIVITY OF BACTERIA ASSOCIATED WITH MARINE SPONGE (HALICLONA AMBOINENSIS) VIA REDUCTING NO PRODUCTION AND INHIBITING CYCLOOXYGENASE 1, CYCLOOXYGENASE 2, AND SECRETORY PHOSPHOLIPASE A2 ACTIVITIES
... sponges will interfere with their sustainability and their habitat. For example, to produce 1 g of anticancer compound, one or more ton of sponges are needed [8]. Therefore, sponge-associated bacteria can be used as an ...
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Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study
... Background: Secretory phospholipase A2 (sPLA2) is a group of enzymes involved in lung tissue inflammation and surfactant catabolism. sPLA2 plays a role in adults affected by acute lung injury and seems a ...
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Differences between group X and group V secretory phospholipase A2 in lipolytic modification of lipoproteins
... 25. Morioka, Y., Saiga, A., Yokota, Y., Suzuki, N., Ikeda, M., Ono, T., Nakano, K., Fujii, N., Ishizaki, J., Arita, H. and Hanasaki, K. Mouse group X secretory phospholipase A2 induces a potent release of ...
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Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants
... List of abbreviations ARDS: acute respiratory distress syndrome; BALF: broncho-alveolar lavage fluids; CBS: captive bubble surfactometry; Crs: static compliance of the respiratory system[r] ...
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Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat
... AA: Arachidonic acid; BBB: Blood brain barrier; COX: Cycloxygenase; DEDA: 7,7'-Dimethyl eicosadienoic acid; EB: Evan's blue; FFA: Free fatty acids; GC: Gas chromatog- raphy; GPx: Glutathione peroxidase; GST: Glutathione ...
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Effect of polyunsaturated fatty acids on secretory phospholipase A2 type IIa in ectopic endometrial cells
... Objective: To assess the effects of ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) administration in endometrial cells culture on sPLA2IIa level and cell surviva[r] ...
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Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti inflammatory agents in a rat model of antigen induced arthritis
... Rats treated orally with either dose of sPLA 2 I 1 or 5 mg/kg two days prior to the injection of mBSA Day -2, and daily throughout, had significantly reduced knee widths throughout the e[r] ...
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Secretory phospholipase-A2 and fatty acid composition in oral reactive lesions: a cross-sectional study
... Given the high prevalence of reactive lesions of the oral cavity and altered metabolism of sPLA2 and fatty acids in the hyperplastic tissues, we investigated the hypothesis that amoun[r] ...
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Regulated formation of eicosanoids
... In other words, the PDGF-medi- pase A2 the Ca2+-dependent cytosolic phospholipase ated increase in cellular PGE2 synthesis depends on de cPLA2, the secretory phospholipase sPLA2; or the [r] ...
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Anti inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in vitro enzyme assays and carrageenan induced paw edema
... Methods: The in vitro tests used to evaluate ethanolic extract are cyclooxygenase-1 COX-1, cyclooxygenase-2 COX-2, lipooxygenase 5-LOX, secretory phospholipase-A2 sPLA2 inhibition assay [r] ...
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Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation
... the secretory endosomes ...in secretory endosomes in ...“atypical” secretory proteins, given their lack of a signal peptide or a transmembrane ...atypical secretory proteins rely on ...
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Cloning and characterization of a novel phospholipase C enzyme, human phospholipase C eta2
... At the resting state, GPCRs are in an inactive conformation and guanine nucleotide diphosphate (GDP) is bound to Gα, which is in a high affinity complex with membrane bound Gβγ. Receptors are activated by ...
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Coordinated activation of the secretory pathway during notochord formation in the Xenopus embryo
... for secretory proteins is not a sudden physiological stress but a ‘predictable’ developmental ...of secretory pathway genes in the developing ...of secretory gene activation in the developing ...
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A study of the temporary adhesion of the podia in the sea star asterias rubens (Echinodermata, asteroidea) through their footprints
... Sea stars are able to make firm but temporary attachments to various substrata owing to secretions released by their podia. A duo-glandular model has been proposed in which an adhesive material is released by two types ...
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Effect of nicotine on secretory component synthesis by secretory epithelial cells.
... review). Secretory IgA antibodies inhibit microbial ad- herence, colonization, and penetration of mucosal surfaces; inhibit metabolic pathways; neutralize enzymes, viruses, and toxins; mediate expulsion of ...
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Novel Mechanisms In The Sorting Of Proglucagon To The Secretory Granules Of The Regulated Secretory Pathway
... whether they are docked at the plasma membrane or nearby, and whether they are immediately releasable or if there is a lag prior to exocytosis. This difference is largely explained by the type of effector proteins on the ...
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