Secretory phospholipase A.
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
... of secretory phospholipase A 2 , cyclooxy- genases, soybean lipoxygenase, and lipopolysaccharides-induced secretion of interleukin-6 and tumor necrosis factor-alpha in mouse ...
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ANTI INFLAMMATORY ACTIVITY OF BACTERIA ASSOCIATED WITH MARINE SPONGE (HALICLONA AMBOINENSIS) VIA REDUCTING NO PRODUCTION AND INHIBITING CYCLOOXYGENASE 1, CYCLOOXYGENASE 2, AND SECRETORY PHOSPHOLIPASE A2 ACTIVITIES
... sponges will interfere with their sustainability and their habitat. For example, to produce 1 g of anticancer compound, one or more ton of sponges are needed [8]. Therefore, sponge-associated bacteria can be used as an ...
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Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: A 21 year cohort
... II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population ...
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Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study
... Background: Secretory phospholipase A2 (sPLA2) is a group of enzymes involved in lung tissue inflammation and surfactant catabolism. sPLA2 plays a role in adults affected by acute lung injury and seems a ...
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Suppressive effect of secretory phospholipase A2inhibitory peptide on interleukin 1β induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
... (PIP)-18), secretory phospholipase A 2 (sPLA 2 ) inhibitor (LY315920) or matrix metalloproteinase inhibitor (MMP-II) at 5 μM for one hour, and incubated with hrIL-1β (10 ng/ml) for 24 hours before isolating ...
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Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2
... Endothelial protein C receptor (EPCR) is an endothelial transmembrane glycoprotein able to bind to a natural anticoagulant, protein C (PC), and its activated form, APC, with similar affinity [5]. Though originally ...
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Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat
... Understanding the effects of lipoxidative load on the mechanisms of pro-inflammatory enzymes, like phos- pholipases A2 (PLA2s), and their modulation for thera- peutic purposes has gained significant recent attention ...
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Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti inflammatory agents in a rat model of antigen induced arthritis
... Rats treated orally with either dose of sPLA 2 I 1 or 5 mg/kg two days prior to the injection of mBSA Day -2, and daily throughout, had significantly reduced knee widths throughout the e[r] ...
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Secretory phospholipase-A2 and fatty acid composition in oral reactive lesions: a cross-sectional study
... Given the high prevalence of reactive lesions of the oral cavity and altered metabolism of sPLA2 and fatty acids in the hyperplastic tissues, we investigated the hypothesis that amoun[r] ...
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Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants
... List of abbreviations ARDS: acute respiratory distress syndrome; BALF: broncho-alveolar lavage fluids; CBS: captive bubble surfactometry; Crs: static compliance of the respiratory system[r] ...
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Anti inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in vitro enzyme assays and carrageenan induced paw edema
... Methods: The in vitro tests used to evaluate ethanolic extract are cyclooxygenase-1 COX-1, cyclooxygenase-2 COX-2, lipooxygenase 5-LOX, secretory phospholipase-A2 sPLA2 inhibition assay [r] ...
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Interactions between Melanin Enzymes and Their Atypical Recruitment to the Secretory Pathway by Palmitoylation
... be secretory by SignalP or Wolf PSORT based on their sequences, and yet, they first ap- pear in the cytoplasm and are then trafficked to endosomes/afla- toxisomes in Aspergillus parasiticus (39, ...
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The Ultrastructure Characteristics of Secretory Cavities Associated with the Secretory Products of Ginkgo biloba
... the secretory cavity would become black when met with osmic acid, as lipid compounds were of lipophilic characteristics ...the secretory and sheath ...the secretory cells (Figure ...the ...
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Novel Mechanisms In The Sorting Of Proglucagon To The Secretory Granules Of The Regulated Secretory Pathway
... Newly forming granules are limited not only by the cargo to be packaged, but also by the specific lipid membrane components. The membrane of the TGN is enriched in phosphatidylinositol-4-phosphate (PI4P), derived from ...
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Coordinated activation of the secretory pathway during notochord formation in the Xenopus embryo
... genes preferentially expressed in different regions of the dorsal mesoderm in late gastrula to early neurula embryos. The dorsal mesoderm was first subdivided into anterior (prechordal) and posterior regions, and the ...
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Regulated formation of eicosanoids
... In other words, the PDGF-medi- pase A2 the Ca2+-dependent cytosolic phospholipase ated increase in cellular PGE2 synthesis depends on de cPLA2, the secretory phospholipase sPLA2; or the [r] ...
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Secretory products of macrophages
... Co-mitogenesis; Chemotaxis Co-mitogenesis; Ia antigen expression; Chemotaxis Increased cytotoxicity, Interleukin 2 receptors Differentiation of precursors; Induction of cytotoxic, Antimi[r] ...
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Neuropeptidergic integration of behavior in Trichoplax adhaerens, an animal without synapses
... SNARE secretory proteins, and voltage-gated calcium channels and SNARE secretory proteins implicated in calcium-regulated secretion (Smith et ...These secretory cells bear a single cilium ...
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Intestinal Phospholipase, a Novel Enzyme
... luminal phospholipase activity was greater than in controls, thus demonstrating that enzyme activity was not due to pancreatic ...of phospholipase activity was excluded in that phospholipase activity ...
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Phospholipase activity in bacteriophage-infected Escherichia. II. Activation of phospholipase by T4 ghost infection.
... coli are infected with T4 ghosts the appearance of free fatty acids is not observed, suggesting that T4 ghost attachment can activate the phospholipase of wild-type E.. Although the form[r] ...
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