secretory phospholipase A 2
ANTI INFLAMMATORY ACTIVITY OF BACTERIA ASSOCIATED WITH MARINE SPONGE (HALICLONA AMBOINENSIS) VIA REDUCTING NO PRODUCTION AND INHIBITING CYCLOOXYGENASE 1, CYCLOOXYGENASE 2, AND SECRETORY PHOSPHOLIPASE A2 ACTIVITIES
... sponges will interfere with their sustainability and their habitat. For example, to produce 1 g of anticancer compound, one or more ton of sponges are needed [8]. Therefore, sponge-associated bacteria can be used as an ...
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Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
... of secretory phospholipase A 2 , cyclooxy- genases, soybean lipoxygenase, and lipopolysaccharides-induced secretion of interleukin-6 and tumor necrosis factor-alpha in mouse ...
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Differences between group X and group V secretory phospholipase A2 in lipolytic modification of lipoproteins
... modified human serum was analyzed with Superose HR 6 10/30 (Amersham- Pharmacia, Uppsala, Sweden) by fast protein liquid chromatography (FPLC). A degassed and filtered solution of 0.15 M sodium chloride, 0.3 mM disodium- ...
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Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti inflammatory agents in a rat model of antigen induced arthritis
... experienced observer, blinded to the treatment groups (Figure 2). All saline-injected, left knees of rats had no observable pathology (data not shown). The induction of arthritis to the right knees of rats ...
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Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat
... The mechanism of IR injury is complex and multi-facto- rial. Among these factors is oxidative stress, which regu- lates neuroinflammation [34,44]. An imbalance in the oxidant-antioxidant homeostasis can be observed by ...
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Effect of polyunsaturated fatty acids on secretory phospholipase A2 type IIa in ectopic endometrial cells
... sampled from our endometriosis patients. Despite of different sampling design, the results are similar to the Gazvani et al study (11) that showed endometrial cells from women with endometriosis in comparison to those ...
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Secretory phospholipase-A2 and fatty acid composition in oral reactive lesions: a cross-sectional study
... enzymes that catalyze the hydrolysis of fatty acids in the sn-2 position of glycerophospholipids of plasma mem- brane [2]. sPLA2 and fatty acids produce a number of key bioactive mediators such as ...
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Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: A 21 year cohort
... The Cardiovascular Risk in Young Finns Study is a population- based prospective follow-up on 3596 Finnish children and adolescents aged 3---18 years who participated at base- line in 1980. In 2001, 2283 of the baseline ...
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Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants
... sPLA2-IIA, -V, and -X are highly expressed in nearly all infants and secreted into the alveoli. These subtypes are also detected, although in lower amount, in some controls and this is consistent with animal data showing ...
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Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study
... Despite a formal sample size calculation is not war- ranted, based on the available data [5,11,19], we pre- viewed a convenience sample size, as follows: 50-60 preterm infants affected by iRDS, with at least 20 receiv- ...
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Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2
... cell survival, apoptosis, viability, cellular stress, and in- flammatory responses. The three major classes of MAP kinases—ERK, p38, and JNK—are all enhanced in RA synovial tissues [37,38]. Survival/growth of RASFs is ...
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Impacts of Cytosolic Phospholipase A2, 15 Prostaglandin Dehydrogenase, and Cyclooxygenase 2 Expressions on Tumor Progression in Colorectal Cancer
... i.e., COX-1 and COX-2. The former is constitutively ex- pressed in a wide variety of tissues, where it serves a homeo- static function. On the other hand, COX-2 is not expressed under normal conditions, ...
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Regulation of tight junction barrier function by phospholipase C
... In order to study PLC in cell-free systems, the presence of a suitable interface between the hydrophilic enzyme and the hydrophobic substrate is required in order to achieve measurable enzymatic activity. The enzyme must ...
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An in vivo study of exocytosis of cement proteins from barnacle Balanus improvisus (D ) cyprid larva
... This finding might question the previous assertion that different types of cells exist in cyprid cement glands containing different types of granules possibly differing in their protein compositions (Walker, 1971). The ...
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Emergence of a metalloproteinase/phospholipase A<sub>2</sub> axis of systemic inflammation
... secreted phospholipase A 2 in the heart. Additionally, MMP-2 deficient mice exhibit abnormally high prostaglandin E 2 levels in various organs (ie, the heart, brain and liver), signs of ...
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Metabolic regulation by secreted phospholipase A2
... from hypertrophic adipocytes preferentially hydrolyzes phosphatidylcholine (PC) in fat-overladen LDL to re- lease unsaturated fatty acids (e.g., oleate and linoleate) in vivo [18]. As such, the increased LDL lipid levels ...
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Antibiofilm Activity of Acidic Phospholipase Isoform Isolated from Bothrops erythromelas Snake Venom
... These enzymes play an important role in the metabolism of lipid molecules and are also related to the production and release of arachidonic acid (AA), a precursor of bioactive lipids, which participates in cellular ...
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The VP1 Unique Region of Parvovirus B19 and Its Constituent Phospholipase A2-Like Activity
... the phospholipase A2 activity with the VP1 protein, we expressed the genome seg- ment spanning the VP1 unique region in Escherichia coli and purified the resultant protein domain comprised of 227 aa by using ...
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Inositol 1,4,5 trisphosphate and inositol 1,3,4,5 tetrakisphosphate are second messenger targets for cardioactive neuropeptides encoded on the FMRFamide gene
... The location of the heart was first determined following removal of the shell. The skin was cut to expose the heart, which was then isolated by cutting through the aorta at the base of the ventricle, and cutting as far ...
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Adenovirus E1A proteins stimulate inositol phospholipid metabolism in PC12 cells.
... Phospholipase C activity was increased severalfold in both membrane and cytosol fractions of 12E1APC12 or 5E1APC12 cells, compared with that in parental PC12 cells Table 2.. However, the[r] ...
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