secretory phospholipase A2
Tracking of secretory phospholipase A2 enzyme activity levels from childhood to adulthood: A 21 year cohort
... II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population ...
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Differences between group X and group V secretory phospholipase A2 in lipolytic modification of lipoproteins
... X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 ...
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Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study
... Background: Secretory phospholipase A2 (sPLA2) is a group of enzymes involved in lung tissue inflammation and surfactant catabolism. sPLA2 plays a role in adults affected by acute lung injury and ...
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Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
... of secretory phospholipase A 2 , cyclooxy- genases, soybean lipoxygenase, and lipopolysaccharides-induced secretion of interleukin-6 and tumor necrosis factor-alpha in mouse ...
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Secretory phospholipase-A2 and fatty acid composition in oral reactive lesions: a cross-sectional study
... Given the high prevalence of reactive lesions of the oral cavity and altered metabolism of sPLA2 and fatty acids in the hyperplastic tissues, we investigated the hypothesis that amoun[r] ...
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Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants
... List of abbreviations ARDS: acute respiratory distress syndrome; BALF: broncho-alveolar lavage fluids; CBS: captive bubble surfactometry; Crs: static compliance of the respiratory system[r] ...
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Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2
... Endothelial protein C receptor (EPCR) is an endothelial transmembrane glycoprotein able to bind to a natural anticoagulant, protein C (PC), and its activated form, APC, with similar affinity [5]. Though originally ...
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Effect of polyunsaturated fatty acids on secretory phospholipase A2 type IIa in ectopic endometrial cells
... Objective: To assess the effects of ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) administration in endometrial cells culture on sPLA2IIa level and cell surviva[r] ...
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Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat
... AA: Arachidonic acid; BBB: Blood brain barrier; COX: Cycloxygenase; DEDA: 7,7'-Dimethyl eicosadienoic acid; EB: Evan's blue; FFA: Free fatty acids; GC: Gas chromatog- raphy; GPx: Glutathione peroxidase; GST: Glutathione ...
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Comparative efficacy of a secretory phospholipase A2 inhibitor with conventional anti inflammatory agents in a rat model of antigen induced arthritis
... Rats treated orally with either dose of sPLA 2 I 1 or 5 mg/kg two days prior to the injection of mBSA Day -2, and daily throughout, had significantly reduced knee widths throughout the e[r] ...
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Anti inflammatory effects of Polygonum minus (Huds) extract (Lineminus™) in in vitro enzyme assays and carrageenan induced paw edema
... COX-1: Cyclooxygenase-1; COX-2: Cyclooxygenase-2; 5-LOX: lipooxygenase; sPLA2: Secretory phospholipase-A2; B.W.: Body weight; AA: Arachidonic acid; PG: Prostaglandins; LT: Leukotrienes; BBB: Blood – ...
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In vitro study of the PLA2 inhibition and antioxidant activities of Aloe vera leaf skin extracts
... IIA phospholipase A2 (hG-IIA) and Me-Indoxam were generous gifts from ...IB phospholipase A2 (pG-IB), Egg yolk phosphatidylcholine or lecithin, red phenol and sodium taurodeoxycholate (NaTDC), ...
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Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis
... The pathophysiology of multiple sclerosis (MS) involves both antigen specific mechanisms and the innate immune system, including elements of the acute inflammatory response [1-4]. Since axonal loss is likely to begin at ...
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Expression of phospholipase A2 receptor and IgG4 in patients with membranous nephropathy
... Phospholipase A2 (PLA2) is a group of enzymes distributed in multiple organs of the human body. It has many subtypes and can bind to PLA2R to form an immune complex, which plays a key role in regulating ...
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Subcellular characteristics of phospholipase A2 activity in the rat kidney Enhanced cytosolic, mitochondrial, and microsomal phospholipase A2 enzymatic activity after renal ischemia and reperfusion
... Phospholipase A2 (PLA2) activities in cytosolic, mitochondrial, and microsomal fractions of rat kidneys were characterized under control conditions, after ischemia, and subsequent to ischemia and ...
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Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma
... Nasopharyngeal carcinoma (NPC) is a low-frequency dis- ease in western countries; however, it is a high-risk head and neck cancer in Southeast Asia and China [1, 2]. In the clinic, concurrent chemoradiotherapy improved ...
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Effect of α-lipoic Acid on Hemolytic Activity of Iranian Vipera Lebetina Venom
... Background and Objective: Snake venom is a complex of several toxic elements and enzymes. It has the agents with the ability to destroy cellular and subcellular membrane and to bring about hemolysis of red blood cells ...
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Regulated formation of eicosanoids
... In other words, the PDGF-medi- pase A2 the Ca2+-dependent cytosolic phospholipase ated increase in cellular PGE2 synthesis depends on de cPLA2, the secretory phospholipase sPLA2; or the [r] ...
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Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85 kD cytosolic phospholipase A2
... Production of leukotriene B4 (LTB4) by human neutrophils (PMN) in response to different stimuli is increased after pretreatment with lipopolysaccharides (LPS). We have analyzed the steps in arachidonic acid (AA) ...
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In vitro antimicrobial activity of natural toxins and animal venoms tested against Burkholderia pseudomallei
... control (Fig. 5). In contrast, the purified PLA 2 s, crotoxin B and daboiatoxin, did not change the viability (Fig. 4f–g) of cells up to 0.05 – 10 μg/mL concentrations as com- pared to the control. The cell viability and ...
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