selective (o)estrogen receptor modulator
Bazedoxifene, a selective estrogen receptor modulator, reduces cerebral aneurysm rupture in Ovariectomized rats
... Bazedoxifene (BZA), a selective estrogen receptor modulator (SERM), is used to prevent postmenopausal osteoporosis. It has fewer estrogenic side effects than conjugated estrogen. SERM ...
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Effects of SERM (selective estrogen receptor modulator) treatment on growth and proliferation in the rat uterus
... a modulator of female reproduction was discussed ...of estrogen promotes proliferation and cellular growth of the rat uter- us ...of estrogen also stimulates factors that affect growth of the uterus ...
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Selective estrogen receptor modulator: efficacy in abnormal uterine bleeding in perimenopausal women
... April 2019 Volume 8 Issue 4 Page 1495 International Journal of Reproduction, Contraception, Obstetrics and Gynecology Mani A et al Int J Reprod Contracept Obstet Gynecol 2019 Apr;8(4) 1495 1499 www ij[.] ...
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Selective estrogen receptor modulator (SERM) for the treatment of osteoporosis in postmenopausal women: focus on lasofoxifene
... Abstract: Selective estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor agonists or antagonists in a tissue- ...
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Improved process for Centchroman, a selective estrogen receptor modulator (SERM)
... The aq phase was extracted with ethyl acetate 2X250 mL, and the combined organic extracts were washed with brine solution 500 mL, and organic phase was dried over Na2SO4 and concentrated[r] ...
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Fbxo22 mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer
... that estrogen signaling is rapidly antagonized after TAM ...that selective degradation of KDM4B complexed with ER by proteasomes might trigger ER cofactor ...that selective degradation of KDM4B on ER ...
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Effects of Toremifene, a Selective Estrogen Receptor Modulator, on Spontaneous and StimulatedGHSecretion, IGF-I, and IGF-Binding Proteins in Healthy Elderly Subjects
... equine estrogen, and estradiol valerate) causes di- minished IGF-I levels in healthy postmenopausal women and that the IGF-I decrease is correlated with the increase in the mean 24-hour serum GH concentration ...
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Clinical update on the use of ospemifene in the treatment of severe symptomatic vulvar and vaginal atrophy
... first selective estrogen receptor modulator indicated in women with moderate-to-severe vaginal atrophy not eligible for local estrogen ...“local estrogen noneligible women” are ...
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Analytical Review on Raloxifene -An Estrogen Receptor Modulator in Different Pharmaceutical Formulations and Biological Fluids
... Abstract Raloxifene (RLX) is an oral selective estrogen receptor modulator (SERM). It is showing estrogenic action on bone and anti-estrogenic action on uterus and breast. An extensive ...
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Ospemifene for the treatment of dyspareunia associated with vulvar and vaginal atrophy: potential benefits in bone and breast
... a selective estrogen receptor modulator (SERM), or estrogen receptor agonist/antagonist, that was recently approved by the US Food and Drug Administration for the treatment of ...
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Combined treatment with dexamethasone and raloxifene totally abrogates osteoporosis and joint destruction in experimental postmenopausal arthritis
... ER: estrogen receptor; FACS: fluorescence-activated cell sorting; H&E: hematoxylin and eosin; HRT: hormone replacement therapy; IL: interleukin; ip: intraperitoneal; OVX: ovariectomy; PBS: phosphate ...
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ALZHEIMER’S DISEASE: A REVIEW
... circumstances estrogen after administration improves the cognitive ...a selective estrogen receptor modulator reduces the risk of dementia in Alzheimer's disease (Research approach from ...
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Effects of Estrogen Receptor Modulators on Morphine Induced Sensitization in Mice Memory
... 46. Nickelsen T, Lufkin EG, Riggs BL, Cox DA, Crook TH. Raloxifene hydrochloride, a selective estrogen receptor modulator: safety assessment of effects on cognitive function and mood in ...
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Estrogen receptor coregulator binding modulator (ERX 11) enhances the activity of CDK4/6 inhibitors against estrogen receptor positive breast cancers
... Alterations in the concentration or activity of selective coregulators enable ER signaling from AE-ER complexes, effectively converting the antagonist to an agonist [15, 16]. Over one third (38%) of ER ...
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Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action
... of estrogen to play a protective role in a vascular injury model is not lost in the αERKO [31 • ] or the βERKO [32 • ] ...each receptor can compensate for the loss of the other or that another mechanism ...
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Selective estrogen receptor modulators: tissue specificity and clinical utility
... Notes: SeRM tissue specificity depends on numerous factors: 1) SERMs have differential and specific affinity for ER subtypes; 2) ER subtypes are differentially expressed in target tissues and can be heterogeneously ...
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Inhibitors of cyclin-dependent kinases as cancer therapeutics.
... transmembrane receptor that undergoes cleavage when activated to release its intracellular domain, ICN1, which then translocates to the nucleus to activate gene- specific ...
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Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators
... take selective estrogen receptor modula- tors (SERMs), such as 4-hydroxytamoxifen (4OHT), to decrease their risk of developing breast cancer ...
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Tamoxifen may prevent both ER+ and ER breast cancers and select for ER carcinogenesis: an alternative hypothesis
... are a mathematical coincidence, or an artifact of the data. If, however, the proposed hypothesis were true, the clinical impli- cation is that while most women at high risk benefit from tamoxifen prophylaxis, there is a ...
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Mechanistic insights into allosteric structure function relationships at the M1 muscarinic acetylcholine receptor
... ativity with ACh, displays a mechanism of action that appears in strict accordance with a simple two-state model of receptor activity (11), and has shown in vivo efficacy (6, 12). We identi- fied several residues ...
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