selective targeting
Cancer cachexia is regulated by selective targeting of skeletal muscle gene products
... the selective downregulation of MyHC (Supplemental Figure ...thermore, selective targeting of MyHC was also observed in mice bearing G361 melanomas, tumors previously shown to secrete the muscle ...
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Selective targeting of melanoma by PEG-masked protein-based multifunctional nanoparticles
... their targeting selectivity and plasma stability were assessed by in vitro and in vivo experiments, HFt-MSH-PEG were recognized and internal- ized specifically by melanoma cells, but not by other human tumor cells ...
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Selective targeting of microglia by quantum dots
... that targeting of microglia with QDs is unlikely to result in toxicity through increased cytokine release, even in the presence of LPS- stimulated microglial ...
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Chromatin accessibility plays a key role in selective targeting of Hox proteins
... protein targeting through the strong effect of chromatin accessibility on Hox binding, with the almost complete occupancy of the most highly accessible regions ...
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Comparison of the selective targeting efficacy of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice
... Salmonella typhimurium A1-R is auxotrophic for arg and leu, which attenuates growth in normal tissue but allows high tumor targeting and virulence. A1-R is effective against metastatic human prostate, breast, and ...
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Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy
... Peptide-mediated targeting of payloads to individual vascular beds has enabled selective delivery of therapeutics to specific organs and tissues [8,9], offering enhanced efficacy and importantly, reducing ...
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Endovascular external carotid artery occlusion for brain selective targeting: a cerebrovascular swine model
... brain- selective therapeutics and diagnostics, and target dose- responses in this larger non-primate model, a model particularly well-suited for investigating larger endovas- cular devices and central nervous ...
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Delivery of the vitamin E compound tocotrienol to cancer cells
... tumor targeting of tocotrienol by entrap- ment within transferrin-bearing vesicles could result in a selective delivery of tocotrienol to tumors after intravenous administration, thus resulting in an ...
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Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis
... for targeting activated platelets, both diagnostically and therapeutically (34, ...(21). Selective targeting to activated platelets ensures enrichment at a growing thrombus and reduces bleeding risk ...
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Lessons from helminth infections : ES-62 highlights new interventional approaches in rheumatoid arthritis
... involves targeting of interleukin (IL)-17 responses, which despite being pathogenic in RA are important for combating infection, we discuss how its selective targeting of IL-17 production by T helper ...
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CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter
... demethylation. Selective epigenetic modifications also resulted in increased gene expression and biological activity of the selected ...the selective substitution of other epigenome modifiers such as ...
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MERTK receptor tyrosine kinase is a therapeutic target in melanoma
... Metastatic melanoma is one of the most aggressive forms of cutaneous cancers. Although recent therapeutic advances have prolonged patient survival, the prognosis remains dismal. C-MER proto-oncogene tyrosine kinase ...
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Neuroblastoma treatment in the post-genomic era
... As so, a very frequent functional abnormalities de- tected in the P53/MDM2/p14 ARF pathway of relapsed patients shed light on its potential clinical targeting. One of the strategies to affect this pathway is by ...
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Human LAP+GARP+FOXP3+ regulatory T cells attenuate xenogeneic graft versus host disease
... Methods: We isolated bona fide Tregs from expansion cultures based on their selective surface expression of latency-associated peptide (LAP). The TCR Vβ diversity and intracellular cytokine production of Tregs ...
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Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma
... than the induced pluripotent stem cells (iPS), which might be able to be used to distinguish these two kind of stem cells [23]. Thus, tumor sphere formation assays were car- ried out to explore whether the stemness of ...
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A Smart Targeting System for Online Advertising
... user-based targeting method for the banner advertisements, and introduced a number of statistics, optimization and scheduling model ...have targeting system from content targeting, frequency ...
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Targeting the heme oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
... Murad, Furchgott, and Ignarro originally outlined the endog- enous NO-cGMP signaling pathway in blood vessels. Since then, different ligands and stimulators ranging from small molecu- lar compounds to proteins have also ...
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TARGETING SELECTIVE TUMOURS BY DEPLOYING MAGNANO PARTICLES THROUGH NANJECTS: RECENT DRUG DELIVERY
... cells by these nanoparticles, eventually can avoid the use of painful syringes. Nanjects skin patches appear as thin silicon wafer that has micro projections made up of polystyrene nano beads. When patched, the ...
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Biosynthesis and Immunogenicity of Glucosylceramide in Cryptococcus neoformans and Other Human Pathogens
... Also, the fatty acid substituents in the GlcCer are long-chain fatty acids (LCFA), usually between 16 and 18 carbons long (93–95, 100) (Fig. 3). This is in contrast to the 24- to 26-carbon chain length present in the ...
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Selective tissue targeting of synthetic nucleic acid drugs
... Tissue targeting of macromolecules has been an active area of research for decades and is beginning to be realized in several therapeutic ...tissue targeting can bring to the ASO ...
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