selenoprotein P
Altered hippocampus synaptic function in selenoprotein P deficient mice
... Interestingly, dietary Se restriction of Sepp1(-/-) mice maintains relatively high concentrations of selenium in the CNS (Sepp1(-/-) 86 ± 12 ng Se/g, Sepp1(+/+) 99 ± 27 ng Se/g) compared to other tissues that often show ...
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Spatiotemporal expression of the selenoprotein P genein postimplantational mouse embryos
... ABSTRACT Selenoprotein P (Sepp) is an extracellular glycoprotein which functions principally as a selenium (Se) transporter and antioxidant. In order to assess the spatiotemporal expression of the Sepp gene ...
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Zuck, Catrin Margarita (2019): Selen und Selenoprotein P - Beeinflussung der Entzündungsreaktion bei polytraumatisierten Patienten. Dissertation, LMU München: Medizinische Fakultät
... dem Selenoprotein P, sowie die direkte antioxidative Kapazität des verabreichten Selens das Redoxgleichgewicht positiv beeinflussen, indem freie Radikale und Zwischenprodukte des Cyclooxigenase- und ...
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Selenoprotein P influences colitis induced tumorigenesis by mediating stemness and oxidative damage
... patients also have compromised antioxidant defenses as the result of nutritional deficiencies. The micronutrient selenium is essential for selenoprotein production and is transported from the liver to target ...
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Comparison of different forms of dietary selenium supplementation on gene expression of cytoplasmic thioredoxin reductase, selenoprotein P, and selenoprotein W in broilers
... ABSTRACT: Effects of different forms of dietary selenium (Se) supplementation on gene expression of cyto- plasmic thioredoxin reductase (TrxR1), selenoprotein P (SelP), and selenoprotein W (SelW) in ...
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Genetic polymorphism in selenoprotein P modifies the response to selenium-rich foods on blood levels of selenium and selenoprotein P in a randomized dietary intervention study in Danes
... plasma selenoprotein P, and the studied polymor- phisms, and within-subject effects between genotype and time for the intervention group, are ...( P = ...plasma selenoprotein P ...
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Effects of Selenium on Selenoprotein Synthesis and Antioxidant Parameters of Bovine Mammary Epithelial Cells
... and selenoprotein P (SelP) can clean oxygen free radicals and maintain redox balance in tissues and ...and selenoprotein synthesis in BMECs are regulated by ...
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The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways
... 15kDa selenoprotein (Sep15) [5–7], thioredoxin reductase 1 (Txnrd1, TR1) [8], and glutathione peroxidase 2 (GPx2) ...and selenoprotein P (SEPP1) with advanced colorectal adenomas in humans ...
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Relevance of selenoprotein transcripts for selenium status in humans
... known selenoprotein biomarkers that have been widely used in discriminating of Se status are as follows: plasma selenoprotein P (SePP1) level and plasma glutathione peroxidase (GPx3) ...
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Protection of Bovine Mammary Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Cell Damage by Selenium
... (TrxR), selenoprotein P (SelP), superoxide dismutase, and catalase in ...of selenoprotein activity were demonstrated further by the increase of mRNA expression for GPX1, TrxR1, and SelP, and protein ...
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Effects of selenoprotein S on oxidative injury in human endothelial cells
... and selenoprotein P (SelP), participate in intra- cellular redox homeostasis and play antioxidative roles ...of Selenoprotein S (SelS), was first characterized as a transmembrane protein in the liver ...
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Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis
... and selenoprotein P (SEPP1) (Table 1 and Fig- ure 2B), as seen in cases with SECISBP2 ...whereas selenoprotein mRNA levels in the proband were either normal or slightly increased (Figure ...
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A randomized trial of selenium supplementation and risk of type 2 diabetes, as assessed by plasma adiponectin
... circulating selenoprotein P was negatively associated with circulating adiponectin in patients with type-2 diabetes [5]; (ii) patients with markedly reduced expression of selenoproteins due to a rare defect ...
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Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer
... in selenoprotein genes are associated with altered disease susceptibility, and only three studies have investigated association with CRC or adenoma ...the selenoprotein P gene (SEPP1) were not ...
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Proteomic analysis of kidneys from selenoprotein M transgenic rats in response to increased bioability of selenium
... SelM was recently reported as a new selenoprotein containing a 145-amino acid open reading frame along with an in-frame TGA as a Sec codon. Further, homolo- gous SelM proteins have been found in various species, ...
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Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population
... Table 2 shows the genotype frequencies of SEPS1 in patients with gastric cancer and the control group. The polymorphism at position -105 of SEPS1 was typed in all 574 subjects. Among cases, the distribution of genotypes ...
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The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism
... 1. Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, ...
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The source of circulating selenoprotein S and its association with type 2 diabetes mellitus and atherosclerosis: a preliminary study
... SelS belongs to the selenoprotein family, which consists of glutathione peroxidases or thioredoxin reductases that contain one selenocysteine [20, 21]. Glutathione peroxi- dase activity was markedly augmented in ...
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Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans
... Selenium, a trace element that is fundamental to human health, is incorporated into some proteins as seleno- cysteine (Sec), generating a family of selenoproteins. Sec incorporation is mediated by a multiprotein complex ...
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Overexpression of Selenoprotein H Reduces Ht22 Neuronal Cell Death after UVB Irradiation by Preventing Superoxide Formation
... Selenoproteins have been shown to exhibit a variety of biological functions, including antioxidant functions, maintaining cellular redox balance, and heavy metal detoxification. UV irradiation-induced damage is partially ...
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