Selenoprotein S
Overexpression of pig selenoprotein S blocks OTA-induced promotion of PCV2 replication by inhibiting oxidative stress and p38 phosphorylation in PK15 cells
... Porcine circovirus type 2 (PCV2) is the primary cause of porcine circovirus disease, and ochratoxin A (OTA)-induced oxidative stress promotes PCV2 replication. In humans, selenoprotein S (SelS) has ...
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Effects of Selenium on Selenoprotein Synthesis and Antioxidant Parameters of Bovine Mammary Epithelial Cells
... and selenoprotein P (SelP) can clean oxygen free radicals and maintain redox balance in tissues and ...and selenoprotein synthesis in BMECs are regulated by ...
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Mutation in human selenocysteine transfer RNA selectively disrupts selenoprotein synthesis
... eukaryotic selenoprotein mRNAs (Figure ...to selenoprotein N (SEPN1) deficiency, increased ROS attributable to lack of antioxidant selenoenzymes — glutathione peroxidases (GPxs) and thioredoxin reductases ...
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Effects of selenoprotein S on oxidative injury in human endothelial cells
... and selenoprotein P (SelP), participate in intra- cellular redox homeostasis and play antioxidative roles ...of Selenoprotein S (SelS), was first characterized as a transmembrane protein in the liver ...
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Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer
... Selenoprotein S is an endoplasmic reticulum protein involved in removing misfolded proteins, and SNP rs28665122 in the SELS promoter has been reported to be associated with altered levels of ...
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Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population
... The study included patients who received an upper gas- trointestinal endoscopy at the Fujita Health University Hospital in Japan. Consecutively enrolled subjects were screened for gastric cancer by upper gastrointestinal ...
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Selenoprotein P influences colitis induced tumorigenesis by mediating stemness and oxidative damage
... Importantly, several SNPs have been identified in SEPP1 that might contribute to decreased expression in tumors. For instance, SNPs in SEPP1 are associated with decreased plasma SEPP1 in men and increased prostate cancer ...
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Protection of Bovine Mammary Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Cell Damage by Selenium
... (TrxR), selenoprotein P (SelP), superoxide dismutase, and catalase in ...of selenoprotein activity were demonstrated further by the increase of mRNA expression for GPX1, TrxR1, and SelP, and protein ...
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The 15kDa Selenoprotein and Thioredoxin Reductase 1 Promote Colon Cancer by Different Pathways
... 15kDa selenoprotein (Sep15) [5–7], thioredoxin reductase 1 (Txnrd1, TR1) [8], and glutathione peroxidase 2 (GPx2) ...and selenoprotein P (SEPP1) with advanced colorectal adenomas in humans ...
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Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans
... defective selenoprotein synthesis. Selenoprotein biosyn- thesis in PBMCs was assessed using 75 Se labeling as described in ...35 S-Met labeling confirmed comparable protein ...
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Is selenoprotein K required for Borrelia burgdorferi infection within the tick vector Ixodes scapularis?
... acid identity with that of A. maculatum suggesting con- served functions. In this work, the selenocysteine inser- tion element (SECIS) of tick selenoK was also predicted by algorithm SECISSearch3 [24]. The SECIS element ...
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(S,S,S,S) Nebivolol hydrochloride hemihydrate
... Preparation of single cristal of (S,S,S,S)-nebivolol hydrochloride was performed according to procedure described by Tuchalski et al. for (R,R,R,R)-nebivolol isomer. The crude product was ...
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Rother, Michael (2002): Selenoprotein-Biosynthese in Archaea: Biochemische und molekularbiologische Analyse. Dissertation, LMU München: Fakultät für Biologie
... Während in allen bisher untersuchten prokaryontischen Systemen die SECIS-Elemente innerhalb der codierenden Region der mRNA lokalisiert sind, befinden sie sich in Archaeen im 3'-nicht- translatierten Bereich der mRNA. ...
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Overexpression of selenoprotein H prevents mitochondrial dynamic imbalance induced by glutamate exposure
... In the present study, we have shown that high concentration of glutamate negatively impacts the mitochondria by altering the mitochondrial structure and dysregulation of mitochondria dynamics, which are associated with ...
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A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer: our experience in thyroid surgery
... Here, we further characterize the role of oxidative stress in thyroid cancer by analyzing the expression of two selenium antioxidant molecules, glutathione peroxidase (GPx1) and thiored[r] ...
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Cloning of the mammalian type II iodothyronine deiodinase A selenoprotein differentially expressed and regulated in human and rat brain and other tissues
... Northern analysis of RNA derived from human tissues reveals expression of DII transcripts in heart, skeletal muscle, placenta, fetal brain, and several regions of the adult brain.. These[r] ...
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Selenoprotein W redox-regulated Ca 2+ channels correlate with selenium deficiency-induced muscles Ca 2+ leak
... The results showed that Se deficiency-induced typical muscular injuries accompanied with Ca2+ leak and oxidative stress P < 0.05 injured the ultrastructure of the sarcoplasmic reticulum [r] ...
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Overexpression of Selenoprotein H Reduces Ht22 Neuronal Cell Death after UVB Irradiation by Preventing Superoxide Formation
... human Selenoprotein H (hSelH) protects neuronal cells against UVB irradiation-induced cell death and if so, whether the protective effect may associate with ROS production prior to observable cell ...
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Proteomic analysis of kidneys from selenoprotein M transgenic rats in response to increased bioability of selenium
... SelM was recently reported as a new selenoprotein containing a 145-amino acid open reading frame along with an in-frame TGA as a Sec codon. Further, homolo- gous SelM proteins have been found in various species, ...
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Spatiotemporal expression of the selenoprotein P genein postimplantational mouse embryos
... ABSTRACT Selenoprotein P (Sepp) is an extracellular glycoprotein which functions principally as a selenium (Se) transporter and antioxidant. In order to assess the spatiotemporal expression of the Sepp gene during ...
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