• No results found

senescence-associated

Senescence associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors

Senescence associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors

... enhance senescence-associated phenotypes in multiple ...of senescence (alopecia, skin atrophy, kyphosis, osteoporosis, testicular atrophy, lipofuscin accumulation in renal proximal tubule and ...

9

Proof of principle: quality control of therapeutic cell preparations using senescence associated DNA methylation changes

Proof of principle: quality control of therapeutic cell preparations using senescence associated DNA methylation changes

... is associated with epigenetic modifications: during in vitro culture, cells acquire senescence-associated DNA methylation (SA-DNAm) changes at specific sites in the ...

5

The impact of senescence-associated T cells on immunosenescence and age-related disorders

The impact of senescence-associated T cells on immunosenescence and age-related disorders

... Immunosenescence is age-associated changes in the immunological functions, including diminished acquired immunity against infection, pro-inflammatory traits, and increased risk of autoimmunity. The proportions of ...

6

Nitrogen deficiency impacts on leaf cell and tissue structure with consequences for senescence associated processes in Brassica napus

Nitrogen deficiency impacts on leaf cell and tissue structure with consequences for senescence associated processes in Brassica napus

... the senescence pro- ...rank senescence pattern (decrease in chlorophyll content and dry mass, ...the senescence associated remobilization pro- cess from its beginning to the leaf ...

14

Senescence associated SIN3B promotes inflammation and pancreatic cancer progression

Senescence associated SIN3B promotes inflammation and pancreatic cancer progression

... Cellular senescence is an irreversible cell-cycle arrest triggered by different stimuli, including oxidative stress, DNA damage, and onco- gene activation, that prevents damaged or mutated cells from prolif- ...

12

Senescence associated proteases: the key players in plant senescence

Senescence associated proteases: the key players in plant senescence

... of senescence is coupled with transcriptional reprogramming, during which expressions of many genes are switched off (Bate, 1991; Hensel, 1993; Guo, ...genes associated with the various developmental phases ...

9

Is senescence-associated β-galactosidase a marker of neuronal senescence?

Is senescence-associated β-galactosidase a marker of neuronal senescence?

... cellular senescence is the activity of senescence- associated- β-galactosidase ...of senescence in aging ...of senescence, namely, double- strand DNA breaks ...a senescence-like ...

11

Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line

Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line

... Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attracted much attention. Indeed, senescent cells secrete a wide assortment of soluble ...

18

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

AICAR and nicotinamide treatment synergistically augment the proliferation and attenuate senescence-associated changes in mesenchymal stromal cells

... Another underlying factor in the pathogenesis of aging is the production of reactive oxygen species (ROS) [11, 15]. Hyperactivation of mTOR can also lead to increased intracellular ROS generation and cellular damage ...

17

p16INK4a and its regulator miR 24 link senescence and chondrocyte terminal differentiation associated matrix remodeling in osteoarthritis

p16INK4a and its regulator miR 24 link senescence and chondrocyte terminal differentiation associated matrix remodeling in osteoarthritis

... Taken together, our results revealed that the senescence- associated CKI, p16 INK4a , triggers the secretion of both MMP1 and MMP13 in mature chondrocytes. These two metalloproteases are matrix remodeling ...

12

Modelling transcriptional networks in plant senescence

Modelling transcriptional networks in plant senescence

... several senescence associated genes and was then demonstrated to accelerate senescence when over-expressed and delay it when knocked-out (Miao et ...the senescence response (Guo & Gan, ...

371

ATF6α regulates morphological changes associated with senescence in human fibroblasts

ATF6α regulates morphological changes associated with senescence in human fibroblasts

... cellular senescence, a gene expression analysis was carried out on senescent ...this senescence gene signature for over-represented Gene Ontology terms and functional assignments (KEGG, PANTHER and ...

17

Antioxidant and inhibition of senescence effects of embelin

Antioxidant and inhibition of senescence effects of embelin

... 2007). Senescence-associated β-galactosidase (SA-β-galactosidase) activity is a characteristic of aged cells and is widely used as an aging cell indicator (Dimri et ...

8

Inhibitory effect of phytol on cellular senescence

Inhibitory effect of phytol on cellular senescence

... ECH- associated protein 1; NF- κ B: Nuclear factor kappa B; NO: Nitric oxide; NRF2: Nuclear factor erythroid 2-related factor 2; P21: Cyclin dependent kinase inhibitor 1A; P53: Tumor protein P53; PBS: Phosphate ...

9

Mechanisms and functions of cellular senescence

Mechanisms and functions of cellular senescence

... is associated with large-scale chromatin rearrange- ments ...of senescence-associated hetero- chromatic foci (SAHFs), which are more prominent in human cells undergoing OIS ...a ...

10

Jumonji C Demethylases in Cellular Senescence

Jumonji C Demethylases in Cellular Senescence

... of senescence through KDM5B activity have been ...increased senescence-associated-β-galactosidase (SA- β-Gal) activity, a marker of senescence (43, ...induced senescence, which results ...

23

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

Replicative senescence is associated with nuclear reorganization and with DNA methylation at specific transcription factor binding sites

... regard, senescence-associated epigenetic modifications seem to be controlled at specific sites in the genome - either ac- tively or passively - and entail the functional changes in the course of replicative ...

15

Is cellular senescence involved in cystic fibrosis?

Is cellular senescence involved in cystic fibrosis?

... be associated with higher levels of IL-6 and transforming growth factor beta (TGF-β) expression and the increased expression of the senescence-inducing cyclin-dependent kinase inhibitors (CDKi) p16 and p21 ...

12

p53 isoforms regulate aging  and tumor associated replicative senescence in T lymphocytes

p53 isoforms regulate aging and tumor associated replicative senescence in T lymphocytes

... Cellular senescence is sustained cell proliferation arrest induced either by telomere attrition (replicative senescence; ...premature senescence; ...cellular senescence of normal tissue stem ...

12

Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers

Senescence cell–associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers

... Cellular senescence is characterized by a proliferation arrest, which protects against cancer, as well as other changes that can also contribute to aging phenotypes and pathologies (7, ...the ...

18

Show all 10000 documents...

Related subjects