sensitivity and inhibition
Sex differences in experimental measures of pain sensitivity and endogenous pain inhibition
... pain sensitivity and disruption of endogenous pain inhibitory processes may account, at least in part, for the greater prevalence and severity of chronic pain in women compared to ...pain sensitivity and ...
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Original Article Inhibition of beclin1 affects the chemotherapeutic sensitivity of osteosarcoma
... the sensitivity to cisplatin for MG63/ DDP and MG63 after inhibition of beclin1 were analyzed in vitro and in ...Meanwhile, inhibition the beclin1 significantly inhibited the formation of ...
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MCR 1 Inhibition with Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli
... ABSTRACT In late 2015, the first example of a transferrable polymyxin resistance mechanism in Gram-negative pathogens, MCR-1, was reported. Since that report, MCR-1 has been described to occur in many Gram-negative ...
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ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition
... the sensitivity induced by ATM- depletion in MCF-7 cells, when treated with iniparib, both ZR-ATMi and ZR-ctr cells showed a substantial loss of viability that was independent of ATM, as indicated by the ...
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Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells
... the sensitivity of NPMc+ and MLL fusion expressing leukemic cells to BET inhibitors and suggests that the addition of autophagy inhibitors to BET inhibitors may be more effective than either approach alone in the ...
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MGMT Inhibition Restores ERα Functional Sensitivity to Antiestrogen Therapy
... growth inhibition gains noted with the combination treatment (BG versus BG + TAM/ICI) may be due to a favor- able phosphorylation phenotype shift triggered by inhibition of MGMT (Fig- ure ...alternatively, ...
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Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors
... Pharmacological inhibition or siRNA-mediated knockdown of cdk1/CCNB1 induced proliferation arrest independent of MYCN status in NB ...cells. Sensitivity to cdk1 inhibition was modulated by TP53, ...
11
The docking protein p130Cas regulates cell sensitivity to proteasome inhibition
... increased sensitivity of Cas-/- MEFs to ...as inhibition of autophagy either by chemical or genetic means enhanced MG132- induced apoptosis in Cas-/- (EV) cells, but not in Cas-FL ...proteasome ...
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RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass
... insulin sensitivity and glucose uptake, and decreased antimyogenic and inflammatory gene expression in muscle, such as myostatin and protein tyrosine phosphatase ...
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Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
... insulin sensitivity is ...by inhibition of insulin binding to insulin receptors [40] or by ADDL-mediated insulin receptor internalization ...by inhibition of its upstream kinase, PDK ...
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Use of Monoclonal Antibody in Diagnosis of Candidiasis Caused by Candida albicans: Detection of Circulating Aspartyl Proteinase Antigen
... low sensitivity, ...an inhibition ELISA using MAb CAP1, the values for categories that are meaning- ful for evaluating the usefulness of diagnostic procedures were improved ...
6
Tyrosine hydroxylase in human adrenal and pheochromocytoma: localization, kinetics, and catecholamine inhibition
... and inhibition kinetics, cofactor requirements, and intracellular localization of the enzyme from normal and tumor chromaffin tissue of humans were similar, as was the amount of enzyme activity per gram of ...the ...
8
Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma
... of sensitivity to Chk1 inhibitor, we compared the baseline gene expression profiles of the cell lines most sensitive to Chk1 inhibitor with the most resistant ones among the entire panel of B-cell lymphoma cell ...
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Enzyme immunoassay for the detection of group A streptococcal antigen
... At an optimal cutoff value of 40% inhibition, sensitivity and specificity by enzyme immunoassay were 97.0% and 97.9%, respectively, as compared with confirmed culture results.. The assay[r] ...
7
Wheat starch biosynthesis : organ specific expression of genes encoding ADP glucose pyrophosphorylase
... In view of the differential sensitivity of wheat leaf and wheat endosperm ADP-glucose pyrophosphorylase enzymes to activation by 3-phosphoglycerate and inhibition by orthophosphate Fente[r] ...
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Mutations in a Conserved Residue in the Influenza Virus Neuraminidase Active Site Decreases Sensitivity to Neu5Ac2en-Derived Inhibitors
... If sensitivity was based on reduction in size in a plaque assay, the difference in the sensitivity of their NA-only mutant with respect to their new reassorted parent control, rather than to the original ...
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MAPK1 E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin
... secretion, HNSCC cells were treated with a dual MAPK1 (ERK2) and ERK1 kinase inhibitor, VX-11e [19]. Ribosomal protein S6 kinase (RSK1) is a MAPK1 (ERK2)-specific downstream substrate [19, 20]. As a pharmacodynamic ...
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Reducing Glycosphingolipid Content in Adipose Tissue of Obese Mice Restores Insulin Sensitivity, Adipogenesis and Reduces Inflammation
... Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological lowering of glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, ...
11
Cellular Reactivity Studies to Streptococcal Antigens MIGRATION INHIBITION STUDIES IN PATIENTS WITH STREPTOCOCCAL INFECTIONS AND REHEUMATIC FEVER
... the inhibition of capillary migration of peripheral blood leucocytes as an index of the degree of sensitivity to streptococcal antigens, the results indicate that patients with acute rheumatic fever exhibit ...
13
Index Catalog // Carolina Digital Repository
... whether inhibition of RAS improves leptin sensitivity, and whether improved leptin sensitivity contributes to the lean and insulin sensitive phenotype of Ren1c-/- ...leptin sensitivity via ...
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