Serine protease inhibitor
Hepatitis B and Hepatitis C Virus Replication Upregulates Serine Protease Inhibitor Kazal, Resulting in Cellular Resistance to Serine Protease-Dependent Apoptosis
... which serine proteases, not caspases, are the critical ...the serine pro- tease inhibitor DCI (3,4-dichloroisocoumarin) (2, 25, ...a serine protease secreted by CTLs and natural killer ...
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Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers
... trypsin inhibitor (TATI), SPINK1 was initially purified from the urine of a patient with serous ovarian adenocarcinoma [6]; very high concentrations of SPINK1 have also been observed in benign and malignant ...
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Microscale coiling in bis imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor
... irreversible serine protease inhibitor whose activity has shown to be successful, inhibiting Kallikrein-5 (K5), 7 a protein that is overexpressed in ailments such as ...
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Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.
... We have identified the major cellular endoprotease that activates the fusion (F) glycoprotein of measles virus (MV) and have engineered a serine protease inhibitor (serpin) to target the endoprotease ...
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Regulation of serine protease inhibitor Kazal type-5 (SPINK5) gene expression in the keratinocytes
... by serine protease activities supplied by the tissue kallikrein gene (KLK) family proteins consisting of fifteen members known as KLK1 to KLK15 ...by serine protease inhibitor Kazal ...
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Nafamostat mesylate, a serine protease inhibitor, demonstrates novel antimicrobial properties and effectiveness in Chlamydia induced arthritis
... other complement-modifying agents, we have examined a synthetic compound, nafamostat mesylate (NM) for its effect on CtIA. NM, formerly known by the name FUT- 175, is a serine protease inhibitor that ...
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Microscale coiling in bis imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor
... a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most ...
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Recovery of serine protease inhibitor from fish roes by polyethylene glycol precipitation
... of serine protease inhibitor (SPI) from fish roe extracts was carried out using polyethylene glycol-4000 (PEG4000) ...The protease inhibitory activity of extracts and PEG fractions from Alaska ...
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Vaccinia virus encodes two proteins that are structurally related to members of the plasma serine protease inhibitor superfamily.
... 600 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Nucleotide sequencing adjacent to the right inverted terminal repetition of the vaccinia virus genome revealed two g[r] ...
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Rhipicephalus microplus serine protease inhibitor family: annotation, expression and functional characterisation assessment
... against serine proteases tested in this study. However, protease inhibition data were obtained only using an intracellular and nonglycosylated RmS1 expressed in ...
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Original Article Schistosoma japonicum serine protease inhibitor increases endothelial barrier function
... the protease inhibition ...the protease activity of elastase in a time-dependent manner; and Sj serpin can increase TER ofendothelial monolayer by decreasing its paracellular size selectivity, but not by ...
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Identification of an interaction between calcium dependent protein kinase 4 (EtCDPK4) and serine protease inhibitor (EtSerpin) in Eimeria tenella
... CDPKs are present in plants, algae, ciliates and api- complexan parasites. In plants, CDPKs regulate plant development and biotic and abiotic stress responses. The N-terminal domain of CDPK plays a key role in ...
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Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection
... These results lead us to hypothesize that it may be fu- sion or uncoating which is compromised, and therefore is blocking the further infection after treatment with AEBSF. However, in our experiments at 37 °C, pre- ...
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Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum
... rule, inhibitory serpins contain glycine at position P15, threonine or serine at P14, and positions P12-P9 are occu- pied by alanine, glycine or serine residues with short-side chains. The corresponding ...
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Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N terminal plakin domain of desmoplakin
... the serine protease inhibitor Kazal-type 5 gene (SPINK5) as causative for Netherton syndrome 1 highlighted the role of excessive stratum corneum protease activity in patients with AD, and ...
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Metal-sensitive and thermostable trypsin from the crevalle jack (Caranx hippos) pyloric caeca: purification and characterization
... classic serine-protease ...the serine in the enzyme active center, blocking the characteris- tic catalytic action of serine protease ...trypsin inhibitor, since this inhibitory ...
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Lethal, neonatal icthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome
... We set out to characterize the murine orthologue of SPINK5 and produce a mouse model of Netherton syndrome. The spectrum of mutations seen in human patients suggested that a complete knockout or null allele of SPINK5 may ...
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Venom proteomics and antivenom neutralization for the Chinese eastern Russell’s viper, Daboia siamensis from Guangxi and Taiwan
... siamensis of Taiwan island; KSPI, Kunitz-type serine protease inhibitor; PLA2, phospholipase A2; Snaclec, snake venom C-type lectin/lectin-like protein; SVSP, snake venom serine protease[r] ...
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DIVERSE CLINICAL FUNCTIONS OF SERINE PROTEASE AND ITS INHIBITORS
... Serine protease performs normal biological functions in cell. Serine protease are involves in coagulation, inflammation and ...produce serine proteases including virus, bacteria, ...
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Nuclear maspin expression as a good prognostic factor in human epithelial ovarian carcinoma
... Maspin (mammary serine protease inhibitor), a pro- tein belonging to serpin superfamily, has been initially Nuclear maspin expression as a good prognostic factor in human epithelial ovar[r] ...
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