Sesquiterpene lactone
Effect of Vernodalol, a Sesquiterpene Lactone, on Economically Important Agricultural Fungi
... [36]. Sesquiterpene lactones in terpenoid class of compounds are commonly produced from most genera in Asteraceae family, and they are mostly found in leaves and flowering heads of plants, available in a range of ...
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NF κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death
... Background: Numerous studies have demonstrated that autophagy plays a vital role in maintaining cellular homeostasis. Interestingly, several anticancer agents were found to exert their anticancer effects by triggering ...
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Efficient Isolation of an Anti Cancer Sesquiterpene Lactone from Calomeria amaranthoides by Steam Distillation
... anti-cancer sesquiterpene lactone, eremophila-1(10)-11(13)-dien-12,8 - olide, was developed from fresh Calomeria amaranthoides plant material on the basis of its non-polar vola- tile ...of ...
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A REVIEW ON THE THERAPEUTIC POTENTIALS OF PARTHENOLIDE: A SESQUITERPENE LACTONE
... compounds, sesquiterpene lactones, which are believed to be the active components of these herbal ...of sesquiterpene lactones is not well ...major sesquiterpene lactone isolated from medical ...
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<p>Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways</p>
... Purpose: Triple-negative breast cancer (TNBC) is a a breast cancer subtype characterized by a lack of estrogen receptor, progesterone receptor and human epidermal growth receptor 2 and is associated with poorer prognoses ...
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Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades
... natural sesquiterpene lactone, is largely distributed in the medical herb Inula helenium and possesses a wide range of biological activ- ities, such as antibacterial, antifungal, anti-inflammatory and ...
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Sesquiterpene lactone! a promising antioxidant, anticancer and moderate antinociceptive agent from Artemisia macrocephala jacquem
... Asteraceae plant family [15, 16]. In the last several years, the potent bioactivities of STLs, such as anti- malarial activity of artemisinin [17], drew significant interests in the biochemistry of STLs [18]. They show ...
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A guaianolide type sesquiterpene lactone
... The present X-ray diffraction analysis of (I) reveals the stereochemistry of the O2 hydroxy group at C3 as the - orientation and that of the methyl atom C13 as the -orien- tation. The Csp 3 —O distances are O2—C3 = 1.410 ...
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Tenulin 0 25 hydrate, a sesquiterpene lactone isolated from Helenium amarum
... The asymmetric unit of the title compound, C17H22O50.25H2O [systematic name: 2-hydroxy-2,2a,6,9a-tetramethyl2a,4a,5,6,6a,9a,9b,9c-octahydro-2H-1,4-dioxadicyclopent[cd,f]azulene-3,9-dione[r] ...
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Synergistic effects of the sesquiterpene lactone, EPD, with cisplatin and paclitaxel in ovarian cancer cells
... tested for their cytotoxic effects; both as single drugs and in combination. We demonstrated herein that EPD showed synergistic interactions with paclitaxel (SK-OV-3 and JC) and cisplatin (JC-pl) (Figures 1 and 2). ...
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Dehydrobrachylaenolide: an eudesmane type sesquiterpene lactone
... isolated from Dicoma anomala Sond. (Asteraceae). The compound contains an endo–exo cross conjugated methyl- enecyclohexenone ring with an envelope conformation trans- fused with cyclohexane and trans-annelated with an - ...
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Dihydroparthenolide diol, a novel sesquiterpene lactone
... The absolute con®guration was determined by re®nement of the Flack parameter. The reported con®guration, which agrees with that of sesquiterpene lactones from higher plants (Fischer et al., 1979), yielded x = ÿ0.3 ...
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Aromaticine, a sesquiterpene lactone from Amblyopappus pusillus
... Sesquiterpene lactones are known to have biological activity, and some guaianolides have antitumor and citotoxic activities (Rodríguez et al. , 1976). The title compound was isolated from aerial parts of ...
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Artemisia annua L : evidence of sesquiterpene lactones’ fraction antinociceptive activity
... enriched sesquiterpene lactone fraction (Lac-FR) was administrated by intraperitoneal injection producing a relevant reduction in the reaction time of the animals in both phases of the formalin test, ...
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PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW OF PROMISING ANTICANCER ROOT OF SAUSSUREA LAPPA CLARKE (FAMILY: ASTERACEAE)
... Saussurea lappa Clarke (SLC) has been utilized as a conventional drug in Korea, China and Japan for the treatment of stomach agony and tenesmus. Costunolide, a sesquiterpene lactone confined from SLC, has ...
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Hydrogen peroxide from cellular metabolism of cystine A requirement for lysis of murine tumor cells by vernolepin, a glutathione depleting antineoplastic
... The evidence presented below implicates cystine metabolism as a previously unappreciated source of intracellular oxidant The sesquiterpene lactone antineoplastic vernolepin acutely stres[r] ...
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Sesquiterpene lactones of Iranian Compositae Family (Astraceae); their Chemical Constituents and Anti-Plasmodial Properties of Tehranolide (A.Review)
... a sesquiterpene lactone containing an endoperoxide linkage in ...oxygenated sesquiterpene lactone peroxide, unlike most other anti-malarials, lacks nitrogens containing heterocyclic ring ...
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Exploring plant sesquiterpene diversity by generating chemical networks
... plant sesquiterpene biosynthesis and aggregating putative biological meaning to the generated network, but there are some related works as AFIR [22]/GRRM, RetroRules [21], and Biotransformer ...
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6α Acetoxyvouacapan 7β,17β lactone
... and lactone derivatives (AbrahaÄo JuÂnior et ...6-hydroxyvouacapan-7,17- lactone compound (AbrahaÄo-Junior et al., 1997), the lactone ring is in an envelope conformation, while the furan ring is ...
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Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast
... (GRACE, Columbia, MD, USA). Fractions were ana- lysed by GC–MS on a Shimadzu GC–MS QP2010 to confirm the presence of the sesquiterpene. Samples were injected into the injector port at 250 °C in splitless mode and ...
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