severe combined immunodeficiency (in mice)
Control of human B cell tumor growth in severe combined immunodeficiency mice by monoclonal anti B cell antibodies
... Severe combined immunodeficiency (scid) mice develop EBV (+)B cell tumors after infusion of EBV(+)B cells or of B cells and ...scid mice were infused with B cell lines derived from ...
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Screening for severe combined immunodeficiency in neonates
... Abstract: Severe combined immunodeficiency (SCID) is a rare disease that severely affects the cellular and humoral immune ...or severe infections and often with chronic diarrhea and failure to ...
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Inhibitory Effect of Ethyl Pyruvate on Orthotopic Transplantation of Gastric Cancer in Severe Combined Immunodeficiency Mice
... in severe combined immunodeficiency (SCID) ...SCID mice were orthotopically transplanted with SGC-7901 human gastric cancer tissue to establish a liver metastasis model of gastric ...SCID ...
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X linked severe combined immunodeficiency Diagnosis in males with sporadic severe combined immunodeficiency and clarification of clinical findings
... with severe combined immunodeficiency (SCID) of unknown genetic etiology are males, yet less than a third of these affected males have a family history of X- linked ...
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The genetic basis of severe combined immunodeficiency and its variants
... Abstract: Severe combined immunodeficiency (SCID) syndromes are characterized by a block in T lymphocyte differentiation that is variably associated with abnormal development of other lymphocyte ...
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Development of a model for marburgvirus based on severe combined immunodeficiency mice
... suckling mice followed by two sequen- tial plaque ...to mice after intraperitoneal inoculation ...infected mice identified similarities and dif- ferences between this model [14,15] and infections in ...
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Development of pemphigus vulgaris like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients
... reconstituting severe combined immunodeficiency (SCID) mice with 1-10 x 10(7) PBL from patients with naturally occurring pemphigus ...reconstituted mice, 34 (69%) produced human IgG ...
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FOXN1 deficient nude severe combined immunodeficiency
... Nude severe combined immunodeficiency is a rare inherited disease caused by autosomal recessive loss-of-function mutations in FOXN1 ...in severe T-cell immunodeficiency, congenital ...
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Can Parents Refuse a Potentially Lifesaving Transplant for Severe Combined Immunodeficiency?
... If untreated, most children with severe combined immunodeficiency disorder (SCID) will die of complications of infection within the first 2 years of life. Early hematopoietic stem cell transplant ...
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Both immunity and hyperresponsiveness to Pneumocystis carinii result from transfer of CD4+ but not CD8+ T cells into severe combined immunodeficiency mice
... The opportunistic pathogen Pneumocystis carinii (Pc) is considered to be the leading cause of morbidity in patients with AIDS. It is important, therefore, to determine the immunological mechanisms of resistance to Pc. We ...
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Biallelic modification of IL2RG leads to severe combined immunodeficiency in pigs
... in mice indicate that there is difference in immune responses of SCID mice based on the ...SCID mice were more effective in supporting engraft- ment of foreign cells compared to their male counter- ...
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Defective expression of p56lck in an infant with severe combined immunodeficiency
... in mice rendered p56lck or p59fyn deficient by homologous recombination ...knockout mice do not signal normally through the TCR and mice lacking p56lck as well as transgenic mice expressing ...
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Novel RAG1 Mutation in a Case of Severe Combined Immunodeficiency
... The patient presented with pneumonitis, which led to progressively deteriorating respiratory dis- tress that improved gradually with corticosteroid treatment. Other than the episode of pneumonitis, the patient had no ...
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Gene therapy for severe combined immunodeficiency: are we there yet?
... Inherited and acquired diseases of the hematopoietic system can be cured by allogeneic hematopoi- etic stem cell transplantation. This treatment strategy is highly successful when an HLA-matched sibling donor is ...
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Why Newborn Screening for Severe Combined Immunodeficiency Is Essential: A Case Report
... 15. Roberts JL, Lauritsen JP, Cooney M, et al. T ⫺ B ⫹ NK ⫹ severe combined immunodefi- ciency caused by complete deficiency of the CD3 zeta subunit of the T cell antigen recep- tor complex. Blood. ...
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Severe Combined Immunodeficiency Resulting From Mutations in MTHFD1
... Because of frequent upper respiratory infections and lack of speci fi c anti- bodies, immunoglobulin (Ig) replace- ment was resumed at 39 months of age. IgA and IgM levels remained within normal ranges. She was diagnosed ...
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Defective expression of T cell associated glycoprotein in severe combined immunodeficiency
... 5 mo after the successful bone marrow transplant, the patient's T cells, which now were Tp40+ and of donor origin, expressed IL-2 receptors in a normal fashion.. Activated normal B cells[r] ...
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Heterogeneity of b lymphocyte differentiation in severe combined immunodeficiency disease
... immunodeficiency having variable proportions of circulating B lymphocytes. When cultured by themselves, the peripheral blood mononuclear cells did not respond to stimulation with pokeweed mitogen in any patient. ...
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Molecular and cellular studies of X-linked severe combined immunodeficiency
... less severe phenotypes associated with intracellular missense mutations or splice site mutations of the Yc gene (DiSanto et a l, 1994b; Schmalstieg et a l, ...
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Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment
... Recombinant human growth hormone (rhGH) promotes human T cell engraftment in mice with severe combined immunodeficiency, suggesting that rhGH may have effects on T cell adhesion and migration ...
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