severe combined immunodeficient
Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.
... adult severe combined immunodeficient (SCID) mice develop chronic infection with T3D, with some mice living more than 100 days after infection ...
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Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans
... the severe combined immunodeficient (SCID) mouse has created a need for characterization of these systems and their application to disease ...
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Immune complexes inhibit antimicrobial responses through interleukin 10 production Effects in severe combined immunodeficient mice during Listeria infection
... The presence of soluble antigen-antibody complexes renders mice highly susceptible to infection with the intracellular pathogen Listeria monocytogenes. In this report we show that this inhibition is manifest at the level ...
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Transfer of rheumatoid arthritis into severe combined immunodeficient mice The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints
... To investigate the pathogenicity of T cells infiltrating in the rheumatoid joints, mononuclear cells (MNC), predominantly T cells, isolated from either synovial fluid or synovial tissues of the patients with RA were ...
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Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes.
... and severe combined immunodeficient (SCID) mice to define viral genes important for organ tropism and virulence in the absence of antigen-specific ...more severe hepatitis than ...
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Human/severe combined immunodeficient mouse chimeras An experimental in vivo model system to study the regulation of human endothelial cell leukocyte adhesion molecules
... the severe combined immunodeficient mouse/human skin transplant model provides a useful in vivo system in which to study human endothelium during the process of ...
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Human Lymphoblastoid CD4+ T Cells Become Permissive to Macrophage-Tropic Strains of Human Immunodeficiency Virus Type 1 after Passage into Severe Combined Immunodeficient Mice through In Vivo Upregulation of CCR5: In Vivo Dynamics of CD4+ T-Cell Differentiation in Pathogenesis of AIDS
... 12 Human Lymphoblastoid CD41 T Cells Become Permissive to Macrophage-Tropic Strains of Human Immunodeficiency Virus Type 1 after Passage into Severe Combined Immunodeficient Mice through[r] ...
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Generation of Severe Combined Immunodeficient (SCID) Pigs: A Novel Large Animal Model for Human Stem Cell Research.
... common subunit that is a necessary component of the cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 (Sugamura et al., 1996). Signaling through IL2RG occurs via the association of its cytoplasmic tail with ...
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ARG098, a novel anti human Fas antibody, suppresses synovial hyperplasia and prevents cartilage destruction in a severe combined immunodeficient HuRAg mouse model
... The cytotoxic effects of ARG098 on cells isolated from RA patients, on normal cells in vitro, and on RA synovial tissue and cartilage in vivo using implanted rheumatoid tissues in an SCI[r] ...
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Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue tropism.
... Murine cytomegalovirus (MCMV) gene products dispensable for growth in cell culture are likely to have important functions within the infected host, influencing tissue tropism, dissemination, or immunological responses ...
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Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy
... on severe combined immunodeficient (SCID) mice, reported that, in addition to significantly enhancing wound-healing rate, MSCs increased the thickness of the regenerated epidermis, increased the ...
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Immune mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
... carinii–infected severe combined immunodeficient mice displayed little evidence of pulmonary inflammation and exhibited normal oxygenation and dynamic lung ...
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Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells
... ALS: Amyotrophic lateral sclerosis; ESC: Embryonic stem cells; iPSC: Induced pluripotent cells; MN: Motor neuron; NF: Neurofilament; SCID: Severe combined immunodeficient; TDP-43: TAR DN[r] ...
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Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms
... and severe combined immunodeficient (SCID) mice who had no T cells, while Gly reduced infarction in both nude rats and SCID mice whose T cells were reconstituted, suggesting that T cells should be ...
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Role of interleukin 4 in human immunoglobulin E formation in hu PBL SCID mice
... We studied the role of IL-4 in human IgE formation in severe combined immunodeficient mice engrafted with peripheral blood mononuclear leukocytes (hu-PBL-SCID). PBL from four nonatopic donors ...
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Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy
... The current study therefore aimed to investigate the effects of CD44 knockdown on the stemness and differentiation of BCSCs in severe combined immunodeficient SCID mice in terms of gene [r] ...
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Defective expression of p56lck in an infant with severe combined immunodeficiency
... Severe combined immune deficiency (SCID) is a heterogeneous disorder characterized by profound defects in cellular and humoral immunity. We report here an infant with clinical and laboratory features of ...
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Novel RAG1 Mutation in a Case of Severe Combined Immunodeficiency
... 2–4 In the absence of effective recombination, the development of a full repertoire of T or B cells is greatly limited, 5,6 leading to the reduced numbers of circulating T and B cells am[r] ...
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Gene therapy for severe combined immunodeficiency: are we there yet?
... Inherited and acquired diseases of the hematopoietic system can be cured by allogeneic hematopoi- etic stem cell transplantation. This treatment strategy is highly successful when an HLA-matched sibling donor is ...
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The genetic basis of severe combined immunodeficiency and its variants
... monogenic, severe T-cell immunodeficiency in humans can be intrinsic to the thymic epithelium or to T ...to severe T-cell deficiency in humans are shown in ...
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