Severe combined immunodeficient mice
Genetic mapping of reovirus virulence and organ tropism in severe combined immunodeficient mice: organ-specific virulence genes.
... SCID mice infected with reoviruses is hepatitis ...neonatal mice (25, ...SCID mice, M1 was important for both titers in tissue and severity of ...neonatal mice and adult SCID mice, the ...
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Immune complexes inhibit antimicrobial responses through interleukin 10 production Effects in severe combined immunodeficient mice during Listeria infection
... renders mice highly susceptible to infection with the intracellular pathogen Listeria ...immuno-competent mice, mice with the severe combined immunodeficient mutation (SCID) ...
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Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans
... the severe combined immunodeficient (SCID) mouse has created a need for characterization of these systems and their application to disease ...SCID mice reconstituted with PBMC support the ...
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Human Lymphoblastoid CD4+ T Cells Become Permissive to Macrophage-Tropic Strains of Human Immunodeficiency Virus Type 1 after Passage into Severe Combined Immunodeficient Mice through In Vivo Upregulation of CCR5: In Vivo Dynamics of CD4+ T-Cell Differentiation in Pathogenesis of AIDS
... FIG. 1. Acquired susceptibility to infection with the SF162 strain of HIV-1 by CEM cells grown in SCID mice. (A) p24 antigen levels in the supernatants of CEM cells infected in vitro with either IIIB (white ...
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Transfer of rheumatoid arthritis into severe combined immunodeficient mice The pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints
... into severe combined immunodeficient (SCID) mice by intraarticular ...SCID mice (the positive ...SCID mice revealed a marked skew towards the preferential use of certain V beta ...
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Brain- and intestine-specific variants of reovirus serotype 3 strain dearing are selected during chronic infection of severe combined immunodeficient mice.
... SCID mice during chronic infection with Sindbis virus (15), the iso- lation of an intestine-specific variant virus such as T3DvInt is ...neonatal mice, the poor efficiency of T3D in intes- tinal replication ...
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Immune mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
... live mice to determine the extent to which pulmonary inflam- mation contributes to respiratory impairment during ...carinii–infected severe combined immunodeficient mice displayed ...
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Role of interleukin 4 in human immunoglobulin E formation in hu PBL SCID mice
... in severe combined immunodeficient mice engrafted with peripheral blood mononuclear leukocytes ...SCID mice whereas engrafted PBL from seven atopic donors secreted IgE with IgE serum ...
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Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue tropism.
... Murine cytomegalovirus (MCMV) gene products dispensable for growth in cell culture are likely to have important functions within the infected host, influencing tissue tropism, dissemination, or immunological responses ...
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Generation of Severe Combined Immunodeficient (SCID) Pigs: A Novel Large Animal Model for Human Stem Cell Research.
... more severe immunodeficiency (Russell et ...in mice severely impairs the development of B and T cells, and completely eliminates NK cells due to their dependence on IL-15 (Cao et ...knockout mice, ...
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Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms
... and severe combined immunodeficient (SCID) mice who had no T cells, while Gly reduced infarction in both nude rats and SCID mice whose T cells were reconstituted, suggesting that T ...
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Development of a model for marburgvirus based on severe combined immunodeficiency mice
... adult mice and, to date, there are no reports of a mouse-adapted MARV ...older mice (suckling to ...in mice and nonhuman primates, including viral tropism for antigen-presenting cells, high viral ...
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Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy
... on severe combined immunodeficient (SCID) mice, reported that, in addition to significantly enhancing wound-healing rate, MSCs increased the thickness of the regenerated epidermis, increased ...
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Safety of Attenuated Smallpox Vaccine LC16m8 in Immunodeficient Mice
... of immunodeficient mouse models. These models included suckling mice, severe combined immunodeficiency disease (SCID) mice, and wild-type mice treated with ...
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Murine Cytomegalovirus Open Reading Frame M27 Plays an Important Role in Growth and Virulence in Mice
... BALB/c mice and immunodeficient SCID mice intraperitoneally, the viral titers in the salivary glands, lungs, spleens, livers, and kidneys were significantly lower than those in mice inoculated ...
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Immune Mediators of Rotavirus Antigenemia Clearance in Mice
... antigenemia, severe-combined-immunodefi- cient (SCID) (on a BALB/c background) (National Cancer Institute, Frederick-Charles River Laboratories [Frederick, MD]) and wild-type BALB/c (The Jackson Laboratory, ...
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Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-<em>scid IL2rγ<sup>null</sup></em> mice treated with alogliptin
... the mice were supplied with BrdU in their drinking ...all mice became acutely hyperglycemic (blood glucose ...alogliptin-treated mice was significantly higher than from vehicle control mice ...
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In Vitro and In Vivo Characterization of a Murine Cytomegalovirus with a Mutation at Open Reading Frame m166
... PFU of Rvm166, Rqm166, or the wild-type Smith strain. At 1, 3, 7, 10, 14, and 21 days postinfection, salivary glands, lungs, spleens, livers, and kidneys were harvested, and the titers of the viral particles from these ...
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A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow
... in immunodeficient NSG mice consistently across five different bone-tropic cancer lines, derived from prostate, breast, lung, and kidney cancer ...engineered mice can be found in the bone marrow of ...
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Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice
... infected mice becoming significantly higher than percentages in uninfected mice at week 12 ...BLT mice have been observed for HIV-specific but not total CD8 ⫹ and CD4 ⫹ T cells in HIV-infected ...
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