Severe combined immunodeficient (SCID)
Limited B cell repertoire in severe combined immunodeficient mice engrafted with peripheral blood mononuclear cells derived from immunodeficient or normal humans
... the severe combined immunodeficient (SCID) mouse has created a need for characterization of these systems and their application to disease ...that SCID mice reconstituted with PBMC ...
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Human Lymphoblastoid CD4+ T Cells Become Permissive to Macrophage-Tropic Strains of Human Immunodeficiency Virus Type 1 after Passage into Severe Combined Immunodeficient Mice through In Vivo Upregulation of CCR5: In Vivo Dynamics of CD4+ T-Cell Differentiation in Pathogenesis of AIDS
... ers was performed to detect all viral RNAs, as reported else- where (10). Sera of infected animals were tested for HIV p24 antigen by an antigen capture enzyme-linked immunosorbent assay (Dupont, Bruxelles, Belgium). For ...
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Generation of Severe Combined Immunodeficient (SCID) Pigs: A Novel Large Animal Model for Human Stem Cell Research.
... Multiple factors were evaluated when comparing transplantation protocols, particularly the efficacy of lymphocyte repopulation, toxicity of the conditioning regimen, morbidity of the transplantation procedure, and ...
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Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells
... ALS: Amyotrophic lateral sclerosis; ESC: Embryonic stem cells; iPSC: Induced pluripotent cells; MN: Motor neuron; NF: Neurofilament; SCID: Severe combined immunodeficient; TDP-43: TAR DN[r] ...
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Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy
... on severe combined immunodeficient (SCID) mice, reported that, in addition to significantly enhancing wound-healing rate, MSCs increased the thickness of the regenerated epidermis, increased ...
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Role of interleukin 4 in human immunoglobulin E formation in hu PBL SCID mice
... in severe combined immunodeficient mice engrafted with peripheral blood mononuclear leukocytes ...in SCID mice whereas engrafted PBL from seven atopic donors secreted IgE with IgE serum levels ...
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Murine cytomegalovirus with a deletion of genes spanning HindIII-J and -I displays altered cell and tissue tropism.
... and severe combined immunodeficient (SCID) mice in spite of its ability to replicate in primary fibroblasts and bone marrow macrophages in ...
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Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms
... and severe combined immunodeficient (SCID) mice who had no T cells, while Gly reduced infarction in both nude rats and SCID mice whose T cells were reconstituted, suggesting that T ...
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Epstein Barr virus induces aggressive lymphoproliferative disorders of human B cell origin in SCID/hu chimeric mice
... development (within 19-33 d) of aggressive, fatal, lymphoproliferative disorders of human B cell origin. Autopsies revealed solid tumors in the abdomen, and occasionally in the liver, thymus, or spleen. Histopathologic ...
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Immune mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia
... carinii–infected severe combined immunodeficient mice displayed little evidence of pulmonary inflammation and exhibited normal oxygenation and dynamic lung ...
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Successful Handling of Disseminated BCG Disease in a Child with Severe Combined Immunodeficiency
... [5] J. M. Puck, A. E. Pepper, P. S. Henthorn et al., “Mutation analysis of IL2RG in human x-linked severe combined immunodeficiency,” Blood, vol. 89, no. 6, pp. 1968–1977, 1997. [6] L. E. Espinosa De Los ...
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Isolation and Propagation of Human Papillomavirus Type 16 in Human Xenografts Implanted in the Severe Combined Immunodeficiency Mouse
... renal capsule on both sides of three 5- to 8-week-old female SCID (C.B-17/Icr Tac-scidfDF) mice (Taconic Farms). The mice were sacrificed 12 weeks later. None of the grafts im- planted at the ear site grew. Of the ...
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Immune Mediators of Rotavirus Antigenemia Clearance in Mice
... antigenemia, severe-combined-immunodefi- cient (SCID) (on a BALB/c background) (National Cancer Institute, Frederick-Charles River Laboratories [Frederick, MD]) and wild-type BALB/c (The Jackson ...
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Poliovirus excretion following vaccination with live poliovirus vaccine in patients with primary immunodeficiency disorders: clinicians’ perspectives in the endgame plan for polio eradication
... 14]. SCID and combined immunodeficiencies are inher- ited predominantly in an autosomal recessive manner, thus in inbred populations, the collective results of the AFP surveillance confirmed that the ...
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Regulation of Adenovirus-Mediated Transgene Expression by the Viral E4 Gene Products: Requirement for E4 ORF3
... to immunodeficient SCID mice led to strong and stable CMV- driven hCFTR expression in the lung, maintained over 100 days (the duration of the experiment ...in SCID and C57BL/6 mice and the rapid ...
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BUBBLE BOY DISEASE AN OVERVIEW
... 1. Treatment aims to restore the immune response and prevent infection. Histocompatible bone marrow transplantation is the only satisfactory treatment available to correct immunodeficiency. Because bone marrow cells must ...
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Brain Trauma Enhances Transient Cytomegalovirus Invasion of the Brain Only in Mice That Are Immunodeficient
... In SCID mice inoculated intravenously 48 h after trauma and killed a week later, groups of infected GFP-positive mCMV-infected cells (green arrow) can be found selectively along the needle track (red ...of ...
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Severe Combined Immunodeficiency Resulting From Mutations in MTHFD1
... of severe combined immunode fi ciency (SCID) with megaloblastic ane- mia, leukopenia, atypical hemolytic uremic syndrome, and neurologic abnormalities in which hydroxocobalamin and folate therapy ...
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Induction of Robust Cellular and Humoral Virus-Specific Adaptive Immune Responses in Human Immunodeficiency Virus-Infected Humanized BLT Mice
... tion and allowed investigators to begin to address important questions in HIV biology in vivo (23, 40, 43–45). More re- cently, human cord blood or fetal liver CD34 ⫹ cells have been used to reconstitute Rag2 ⫺/⫺ ...
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Elimination of rheumatoid synovium in situusing a Fas ligand 'gene scalpel'
... Molecular surgery to remove the pathological cells and tissues in situ by gene transfer could be an important part of molecular medicine. Molecular synovectomy using gene scalpels simpli- fies the current problems of ...
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