Severe hemophilia
<p>Mild-severe hemophilia B impacts relationships of US adults and children with hemophilia B and their families: results from the B-HERO-S study</p>
... with severe hemophilia including those with inhi- bitors, who have up until this point been very engaged with their treatment centers and the ...a severe to mild phenotype, there is the potential ...
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Cost–utility analysis of prophylaxis versus treatment on demand in severe hemophilia A
... Methods: A Markov model was developed and run using different sources of clinical, cost, and utility data. The model was populated with a hypothetical cohort of 100 individuals with severe hemophilia A. The ...
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Review of antihemophilic factor injection for the routine prophylaxis of bleeding episodes and risk of joint damage in severe hemophilia A
... Nonrandomized as well as randomized studies have accu- mulated a plethora of data on prophylactic FVIII infusions in patients with severe hemophilia A, documenting the beneficial results of decreased ...
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Reduced Bone Density Among Children With Severe Hemophilia
... with severe hemophilia may be difficult, particularly for patients with established hemophilic arthropathy changes. However, supervised exercise training per- formed at times of maximal clotting factor ...
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New developments in the management of moderate-to-severe hemophilia B
... in hemophilia B therapy are focused on overcoming the barriers to broader use of prophylaxis, including require- ment for IV access, compliance with frequent infusions, poor recovery of rFIX, and ...in ...
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Athletic Participation in Severe Hemophilia: Bleeding and Joint Outcomes in Children on Prophylaxis
... have severe hemophilia and prin- cipally are maintained on prophylactic factor replacement and to compare outcomes with respect to type of ath- letic participation and preparticipa- tion baseline joint ...
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Challenges and successes in the treatment of hemophilia: the story of a patient with severe hemophilia A and high-titer inhibitors
... This article highlights the case of a 27-year-old Asian male who was diagnosed as having severe hemophilia at the time of his birth. He initially received on-demand factor VIII (FVIII) infusion and a ...
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Current animal models of hemophilia: the state of the art
... with severe hemophilia ...to hemophilia A mice, hemophilia B mice do not show spontaneous bleeding, but will bleed and die after tail clipping unless the wound is ...cauterized. ...
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Recombinant factor VIII in the management of hemophilia A: current use and future promise
... of hemophilia A involves the complications from use of central venous access devices to administer factor VIII every other ...the hemophilia treatment center, and on the efforts of the families involved in ...
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Defining the Impact of Hemophilia: The Academic Achievement in Children With Hemophilia Study
... Conclusions. Each child should have the opportunity to achieve his or her potential. Control of a chronic dis- order must include this important goal as well as the more commonly identified medical outcomes. This study ...
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Desensitization and immune tolerance induction in children with severe factor IX deficiency; inhibitors and adverse reactions to replacement therapy: a case-report and literature review
... with severe hemophilia A but only 1-3% of those with hemophilia B ...of severe hemophilia B results from missense mutations [8], providing an in- creased proportion of antigenic ...
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“Cost of Illness Patients with Hemophilia in RSUP Dr. Sardjito Yogyakarta” by Umi Nafisah, Satibi, Diah Ayu Puspandari, Indonesia.
... of Hemophilia based on the hospital perspective, to know the difference between the cost of illness patients with hemophilia A and hemophilia B, to investigate the effect of the inhibitor on the cost ...
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Issues in pediatric haemophilia care
... of severe hemophilia A patients and in only 3-5% of those with hemophilia B, render replacement therapies ineffective ...with hemophilia: host predisposition to FVIII inhibitors has been ...
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To study the occurrence of inhibitors in children affected with hemophilia ‘A’ and hemophilia ‘B’ disease
... screen hemophilia affected patients for the presence of ...100 hemophilia A and B patients were screened for the presence of inhibitors to Factor VIII and Factor ...100 hemophilia patients screened ...
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Developments in the treatment of hemophilia B: focus on emerging gene therapy
... Abstract: Hemophilia B is a genetic disorder that is characterized by a deficiency of clotting factor IX (FIX) and excessive ...with hemophilia B are ideal candidates for gene therapy, mostly because a ...
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A case of subdural hematoma with a medical history of hemophilia a and a review of related literature
... of hemophilia A and the severity of the disease, we measured his factor VIII activity levels in an APTT-based assay (APTT prolongation ...as hemophilia severity ...with severe hemophilia ...
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... National Hemophilia Treatment Center in March- September ...with severe hemophilia A (factor VIII <1%), history of repeated joint bleeds, and previously received episodic ...
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Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors
... hereditary severe hemophilia A with inhibitor were treated with rituximab in one ...any severe infection after rituximab but some reports showed infection in patients with central venous catheter ...
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Treatment adherence in hemophilia
... Abstract: Prophylactic clotting-factor regimens reduce the occurrence of bleeding episodes and maintain joint health in individuals with moderate and severe hemophilia. However, these outcomes are only ...
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Prevalence of Inhibitors in Patients with Hemophilia Treated with Factor VIII or IX Transfusion in Coimbatore Medical College Hospital
... Results from the study showed that inhibitor development were more common in severe hemophilia A than severe hemophilia B .Patients with more number of cumulative exposure days, earlier [r] ...
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