Sézary syndrome
Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sézary syndrome, and HIV infection
... with Sézary syndrome (Sz) were cared for elsewhere, one at the University of Michigan and the Dana Farber Hospital, Boston, MA and a second one (our index case) at Yale University, New Haven, CT and North ...
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The Sézary syndrome: a malignant proliferation of helper T cells
... The Sézary syndrome is a frequently lethal disease characterized by circulating malignant cells of thymus-derived (T)-cell ...this syndrome to synthesize immunoglobulins and to function as helper or ...
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Diagnostic and prognostic markers in tumor stage mycosis fungoides and Sézary syndrome
... for Sézary syndrome using standard operating procedures: a multicenter study of 59 ...of Sézary syndrome defines patterns of aberrant DNA methylation and identifies diagnostic ...
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Rapid and sustained response to immune checkpoint inhibition in cutaneous squamous cell carcinoma after allogenic hematopoietic cell transplant for sézary syndrome
... and Sézary Syndrome (SS) can debilitate the immune response against malignant cells in the tumor microenvironment and thus could be considered a target for therapies that can restore immune surveil- lance ...
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DNA Content Analysis by Flow Cytometry and Cytogenetic Analysis in Mycosis Fungoides and Sézary Syndrome: DIAGNOSTIC AND PROGNOSTIC IMPLICATIONS
... Flow cytometric (FCM) analysis of DNA content was performed on 82 lymph node and peripheral blood specimens from 46 patients with mycosis fungoides and the Sézary syndrome. Overall, 32 of the 46 patients ...
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EPHA4 is overexpressed but not functionally active in Sézary syndrome
... Sézary syndrome (SS) is a rare leukemic variant of cutaneous T-cell lymphoma (CTCL) that is characterized by erythroderma, generalized lymphadenopathy, and the presence of neoplastic CD4+ skin-homing memory ...
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EPHA4 is overexpressed but not functionally active in Sézary syndrome
... Sézary syndrome (SS) is a rare leukemic variant of cutaneous T-cell lymphoma (CTCL) that is characterized by erythroderma, generalized lymphadenopathy, and the presence of neoplastic CD4+ skin-homing memory ...
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A mouse model for the Sézary syndrome
... In contrast to other malignancies, it has been difficult to establish mouse models for CTCLs as mycosis fun- goides and the Sézary syndrome [7-10]. For MF a mouse model has been developed [7] that has ...
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Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndrome
... Sézary syndrome (SS) carries a poor prognosis, and infections represent the most frequent cause of death in SS patients. Toll-like receptors (TLRs) are a family of innate immune receptors that induce ...
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Clinicopathological Correlation and Outcome in peripheral T cell lymphomas (PTCL): A Retrospective study
... Angioimmunoblastic T cell Lymphoma AITL Mycosis fungoides/Sézary syndrome Primary cutaneous CD30+ T-cell LPD, LYP and primary cutaneous ALCL Cutaneous Primary cutaneous CD4+ small/medium[r] ...
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Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma
... equivalent of mycosis fungoides, is defined as having the triad of erythroderma, generalized lymphadenopathy, and the presence of neoplastic T cells in the skin, lymph nodes, and peripheral blood. Sézary ...
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A Five Year Retrospective Study of Spectrum of Cutaneous Lymphomas presenting to a Tertiary Care Centre
... Cutaneous T and NK cell lymphomas Mycosis fungoides MF variants and subtypes Folliculotropic MF Pagetoid reticulosis Granulomatous slack skin Sézary syndrome Adult T-cell leukemia/lympho[r] ...
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Interleukin 7 is a growth factor for Sézary lymphoma cells
... Sézary syndrome is a cutaneous T cell lymphoma characterized by infiltration of the skin by CD4+ cells. These cells generally respond poorly to mitogens and T cell activators. We have studied the action of ...
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The expanding spectrum of rare monogenic autoinflammatory diseases
... Monogenic autoinflammatory diseases are a group of hereditary disorders characterized by a clinical and biological inflammatory syndrome in which there is little or no evidence of autoimmunity. The discovery of ...
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Systemic Lupus Erythematosus: A Review
... hypertension syndrome, characterized by an elevated intracranial pressure, papilledema, and headache with occasional abducens nerve paresis, absence of a space-occupying lesion or ventricular enlargement, and ...
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The Fifth Phakomatosis – A Case Report
... rare syndrome. 5 It is useful to keep in mind the existence of this syndrome and to recognize the presence of some major criteria that are easily recognizable on thorough clinical examination, CT scan and ...
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Extra Aneurysmal Flow Modification Following Pipeline Embolization Device Implantation: Focus on Regional Branches, Perforators, and the Parent Vessel
... RESULTS: Slow flow was observed in 13 of 68 (19.1%) side branches covered by the Pipeline Embolization Device. It was reported in all cases of anterior cerebral artery coverage, in 3/5 cases of M2-MCA coverage, and in ...
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... basilar syndrome, cerebral venous throm- bosis, transient cerebral hyperemia, Creutzfeldt-Jakob dis- ease, gliomatosis cerebri, infectious meningitis, encephalitis, post-infectious encephalomyelitis, vasculitis, ...
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Significance of defecography and the role of rectocele in constipated patients
... Constipation is functionally separated into the follow- ing subgroups: slow colonic transit, normal colonic tran- sit, and defecatory or rectal evacuation abnormalities [2]. Disorders that are associated with pelvic ...
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A Study on Diseases Affecting Litopenaeus vannamei Farming in Coastal Districts of Andhra Pradesh, India
... Loose Shell Syndrome (LSS) was observed in majority of ponds in all the four districts i.e., Guntur, Krishna, West Godavari and East Godavari districts (Fig. 5). Previously studies also reported in the cultured ...
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